助手标题  
全文文献 工具书 数字 学术定义 翻译助手 学术趋势 更多
查询帮助
意见反馈
   器官特异性自身免疫性疾病 的翻译结果: 查询用时:0.405秒
图标索引 在分类学科中查询
所有学科
更多类别查询

图标索引 历史查询
 

器官特异性自身免疫性疾病
相关语句
  organ specific autoimmune disease
     Objectives:The Graves Disease (GD) is a kind of organ specific autoimmune disease which is induced by immune response to self component from organism immune system under the interaction of both environmental and hereditary factors.
     Graves病(Graves Disease,GD)是一种器官特异性自身免疫性疾病,是在环境因素与遗传因素相互作用下,机体免疫系统对自身成分发生免疫应答而导致的疾病状态。
短句来源
     ObjectiveType 1 diabetes has been recognized as organ specific autoimmune disease owing to the immune destruction of pancreatic islet β cells in genetically susceptible individual.
     1型糖尿病是遗传学上易感个体胰岛β细胞被宿主免疫细胞选择性破坏而引起的器官特异性自身免疫性疾病
短句来源
     Now it is considered as an organ specific autoimmune disease.
     目前认为它是一种器官特异性自身免疫性疾病
短句来源
  “器官特异性自身免疫性疾病”译为未确定词的双语例句
     Autoimmune thyroid disease(AITD) is a common organ-specific autoimmune disease.
     自身免疫性甲状腺疾病(AITD)是常见的器官特异性自身免疫性疾病
短句来源
     The Graves’disease(GD) is the organ-specific autoimmune disease which is mediated by T lymphocyte. B7-CD28/CTLA-4,the most important costimulatory molecule,is required for activation and proliferation of T cells. It has been suggested that B7-CD28/CTLA-4 plays a significant role in initiation,retaining,effection stages of dysimmunity in GD.
     Graves病是T淋巴细胞介导的器官特异性自身免疫性疾病,以B7-CD28/CTLA-4为主的协同刺激分子作为影响T淋巴细胞活化、增殖的必要条件,其在Graves病异常免疫反应的启动、维持和效应阶段均发挥重要作用。
短句来源
     PrefaceType 1 diabetes is an organ - specific autoimmune disease mediated by T cell and lung is a target organ of diabetes damaging.
     1型糖尿病是一种T细胞介导的器官特异性自身免疫性疾病,肺组织也是糖尿病损害的靶器官。
短句来源
     Background: Autoimmune thyroid diseases (AITD), including Graves disease (GD), Hashimoto's thyroiditis (HT), idiopathic myxedema (IM), postpartum thyroiditis (PPT), and thyroid-associated orbitopathy (TAO), are organ-specific autoimmune diseases. AITD are the most common autoimmune disorders in population, affecting between 2% and 4% of women and up to 1% of men.
     背景:自身免疫性甲状腺病(Autoimmune thyroid dieases,AITD)是一组器官特异性自身免疫性疾病。 自身免疫性甲状腺病主要包括Graves病(Graves disease,GD)、桥本甲状腺炎(Hashimoto's thyroiditis,HT)、特发性粘液性水肿(idiopathic myxedema,IM)、Graves眼病(Graves ophthalmopathy,GO)和产后甲状腺炎(postpartum thyroiditis,PPT)等疾病。
短句来源
     Autoimmune thyroid diseases (AITD) as the organ -specific autoimmune diseases are very common in human. Many factors such as individual genetic susceptibility, autoimmunity, endocrinology and environmental conditions are involved in the initiation and development of AITD.
     自身免疫性甲状腺疾病(autoimmune thyroid disease, AITD)是一种常见的器官特异性自身免疫性疾病,其发病受个体遗传因素的易感性、自身的免疫状态、内分泌系统和外环境条件等多种因素影响。
短句来源
更多       
  相似匹配句对
     Now it is considered as an organ specific autoimmune disease.
     目前认为它是一种器官特异性自身免疫性疾病
短句来源
     Autoimmune thyroid disease(AITD) is a common organ-specific autoimmune disease.
     自身免疫性甲状腺疾病(AITD)是常见的器官特异性自身免疫性疾病
短句来源
     Systemic Lupus Erythematosus is a non-specific organautoimmune disease.
     系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种器官特异性自身免疫性疾病
短句来源
     As organ-specific autoimmune diseases, immunological mechanism plays an important role in the pathogenesis of AITD.
     作为器官特异性自身免疫性疾病,免疫机制在自身免疫性甲状腺病的发病中有着重要的作用。
短句来源
     Thyroid associated ophthalmopathy is an organ special autoimmune disorder, of which the pathogenesis is still unclear.
     甲状腺相关眼病是一种器官特异性自身免疫性疾病,确切的发病机制尚不清楚。
短句来源
查询“器官特异性自身免疫性疾病”译词为用户自定义的双语例句

    我想查看译文中含有:的双语例句
例句
为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法,我们为您准备了出自英文原文的大量英语例句,供您参考。
  organ specific autoimmune disease
The initial step in the developement of organ specific autoimmune disease in BB rats
      
The coexistence of nonorgan specific and organ specific autoimmune disease is discussed.
      
However a causal association between organ specific autoimmune disease and airflow obstruction is plausible.
      
No patient had clinically evident polysystemic or organ specific autoimmune disease.
      
This group had a high prevalence of organ specific autoimmune disease and autoantibodies, in particular thyroid disease.
      


Insulin Dependent Diabetes Mellitus(IDDM),as an organ-specific autoimmune disease,has a long preclinical period and humoral immune markers can be used to identify individauls at high risk of developing IDDM.As a major immune marker,islet cell antibodies(ICA)with high titer(>40JDFU) confera much greater risk than that with low titer(20JDFU).Insulin autoantibodies(IAA)can enhance the predictive value of ICA.With the more marked correlation to the progressive damage of pancreatic β cell,glutamic acid decarboxylase...

Insulin Dependent Diabetes Mellitus(IDDM),as an organ-specific autoimmune disease,has a long preclinical period and humoral immune markers can be used to identify individauls at high risk of developing IDDM.As a major immune marker,islet cell antibodies(ICA)with high titer(>40JDFU) confera much greater risk than that with low titer(20JDFU).Insulin autoantibodies(IAA)can enhance the predictive value of ICA.With the more marked correlation to the progressive damage of pancreatic β cell,glutamic acid decarboxylase antibodies(GAD Ab)present greater predictive power than either ICA or IAA does.Combined testing of GAD Ab ICA and IAA can improve the predictive value for IDDM.The predictive value for IDDM with autoantibodies is influenced by genetic background and hence has been assessed exclusively in their first degree relatives of IDDM patients.

胰岛素依赖型糖尿病(insulindependentdiabetesmelitus,IDDM)为器官特异性自身免疫性疾病,细胞免疫和体液免疫均参与其病理过程。虽然IDDM通常为急性起病,但在其发病前胰岛β细胞的免疫损害过程常需经历数年从而有一个较长...

Objective To construct FADDdel plasmid capable of blocking the Fas triggered intracellular signal transduction and to prepare technology ability for the further inquiring into transplantation by modifying the target cells in gene level. Methods The target gene of FADDdel, designated Fas associated death domain protein(FADD) without N terminal death effective domain(DED), was amplified from human blood lymphocyte by RT PCR and then inserted into the pUC pIC vector. The structure was confirmed by digestion...

Objective To construct FADDdel plasmid capable of blocking the Fas triggered intracellular signal transduction and to prepare technology ability for the further inquiring into transplantation by modifying the target cells in gene level. Methods The target gene of FADDdel, designated Fas associated death domain protein(FADD) without N terminal death effective domain(DED), was amplified from human blood lymphocyte by RT PCR and then inserted into the pUC pIC vector. The structure was confirmed by digestion and DNA sequencing. After the transfection of human β cell strain(NIT) with pFADDdel, apoptosis of NIT with or without pFADDdel induced by FasL was detected by FACS. The 3 D structure of FADDdel was successfully constructed, analyzed and compared with stereodrawing of the FADD by means of digital molecule mode technology online. Results A 500bp target gene fragment was obtained by RT PCR. Digestion and DNA sequencing showed that the recombinant plasmid pFADDdel was successfully constructed. After transfection, FADDdel high expression cell strain F15 has been built up. pFADDdel prevented the death of F15 induced by sFasL even cultured with IFN γ and TNF α. Analyzing of function structure domain of FADD and FADDdel showed molecule mechanism of FADDdel protein in blocking signal transduction pathway of apoptosis. Conclusions In the present study, we have established human β islet cells strain which can steadily express the pFADDdel. pFADDdel can block the apoptosis signal of Fas and TNF R1. It is a solid base for the further study of transplantation immunity and organ special autoimmune disease. [

目的 建立Fas相关死亡域 (FADD)缺失突变体的表达细胞系 ,阻断Fas死亡信号传导 ,以便今后更深入的探讨通过基因水平修饰靶细胞 ,改变靶细胞的反应状态 ,对移植免疫和自身免疫性疾病的可能的影响。方法 用RT PCR从感染患者外周血淋巴细胞中获得缺失FADD死亡域目的基因片段 (FADDdel) ,利用双酶切将FADDdel定向导入真核表达载体pUC pIC ;用电穿孔法将重组子导入人 β胰岛细胞株 (NIT)中 ,采用FACS法检测sFasL所引起的转染前后NIT凋亡情况。同时在In ternet中通过计算机数字化分子模型技术 ,成功模建FADDdel的 3D结构并与FADD的立体结构进行比较与分析。结果 RT PCR法得到约 5 0 0bp的目的基因片段 ,转化子用BglⅡ ,XbaⅠ酶切后得到 3个特异性片段 ,经酶切和测序鉴定为FADD缺失突变的重组体 (pFADDdel)。将pFADDdel导入NIT后 ,筛选出高表达细胞系F15 ,在IFN γ和TNF α存在时F15仍能有效拮抗sFasL诱导的凋亡 ;并对FADD和FADDdel功能结合域和结合位点分析 ,阐明了FADDdel蛋白质分子在阻...

目的 建立Fas相关死亡域 (FADD)缺失突变体的表达细胞系 ,阻断Fas死亡信号传导 ,以便今后更深入的探讨通过基因水平修饰靶细胞 ,改变靶细胞的反应状态 ,对移植免疫和自身免疫性疾病的可能的影响。方法 用RT PCR从感染患者外周血淋巴细胞中获得缺失FADD死亡域目的基因片段 (FADDdel) ,利用双酶切将FADDdel定向导入真核表达载体pUC pIC ;用电穿孔法将重组子导入人 β胰岛细胞株 (NIT)中 ,采用FACS法检测sFasL所引起的转染前后NIT凋亡情况。同时在In ternet中通过计算机数字化分子模型技术 ,成功模建FADDdel的 3D结构并与FADD的立体结构进行比较与分析。结果 RT PCR法得到约 5 0 0bp的目的基因片段 ,转化子用BglⅡ ,XbaⅠ酶切后得到 3个特异性片段 ,经酶切和测序鉴定为FADD缺失突变的重组体 (pFADDdel)。将pFADDdel导入NIT后 ,筛选出高表达细胞系F15 ,在IFN γ和TNF α存在时F15仍能有效拮抗sFasL诱导的凋亡 ;并对FADD和FADDdel功能结合域和结合位点分析 ,阐明了FADDdel蛋白质分子在阻断细胞凋亡胞内信号传导通路的分子机制。结论 成功建立了FADDdel稳定表达的人胰岛细胞株 ;pFADDdel能有效抑制Fas和TNFR1介导的胞内凋亡信号通路 ;为进一步研究移植免疫和器官特异性自身免疫性疾病的发生机制提供了理论

Autoimmune thyroid diseases(AITD) are the most prevalent organ-specific autoimm u ne disorders in humans. However,the pathogenesis of AITD remains obscure. Most research showed that AITD is induced by interaction between genetic predisposition an d various environmental factors. This article briefly summarizes the current imm unologic understanding of the pathogenesis of autoimmune thyroid diseases.

自身免疫性甲状腺疾病(AITD)是最常见的器官特异性自身免疫性疾病,但其发病机制尚未完全明了,目前的认识是:AITD是由多种环境因素与遗传因素相互作用产生的自身免疫应答所引起.本文就近年来AITD免疫发病机制的主要进展作一简要回顾.

 
<< 更多相关文摘    
图标索引 相关查询

 


 
CNKI小工具
在英文学术搜索中查有关器官特异性自身免疫性疾病的内容
在知识搜索中查有关器官特异性自身免疫性疾病的内容
在数字搜索中查有关器官特异性自身免疫性疾病的内容
在概念知识元中查有关器官特异性自身免疫性疾病的内容
在学术趋势中查有关器官特异性自身免疫性疾病的内容
 
 

CNKI主页设CNKI翻译助手为主页 | 收藏CNKI翻译助手 | 广告服务 | 英文学术搜索
版权图标  2008 CNKI-中国知网
京ICP证040431号 互联网出版许可证 新出网证(京)字008号
北京市公安局海淀分局 备案号:110 1081725
版权图标 2008中国知网(cnki) 中国学术期刊(光盘版)电子杂志社