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Reversal of multidrug resistance of gastric cancer cells by downregulation of CIAPIN1 with CIAPIN1 siRNA
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The overexpression of a new cytokine-induced apoptosis inhibitor 1 (CIAPIN1) gene has been shown previously to promote a multidrug resistant phenotype in gastric cancer cells through the upregulation of MDR1 and MRP1.
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CIAPIN1 siRNA could significantly downregulate the expression of Bcl-2, and upregulate the expression of Bax, but does not alter the expression of PTEN in gastric cancer cells.
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These observations suggested that the siRNA constructs of CIAPIN1 we obtained could effectively downregulate the expression of CIAPIN1 and reverse the resistant phenotype of gastric cancer cells.
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Further study of the biological functions of CIAPIN1 may be helpful for understanding the mechanisms of multidrug resistance of gastric cancer and in developing possible strategies to treat gastric cancer.
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MSI/LOH and extron expression of the FHIT gene in gastric carcinoma
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There was no correlation between LOH and MSI of the FHIT gene in GC and the histological characteristics of gastric carcinoma (Bormann's or Lauren's classification).
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In order to explore the effects of garlic oil on carcinoma cells, a gastric carcinoma cell line, BGC-823 was studied at cellular and molecular levels after garlic oil treatment.
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In our previous work, increased DCs cross-presentation of antigens from necrotic gastric carcinoma cells paralleled up-regulation of the heat shock protein hsp70.
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Role of CD97stalk and CD55 as molecular markers for prognosis and therapy of gastric carcinoma patients
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Human hematopoietic cell K562, human melenonla cell LiBr and human stomach cancer cells were exposed to ultrasound (US, 1.75 W/cm2, 1.4, 2.16 and 2.4 MHz)in vitro in the presence or absence of hematoporphyrin (Hp, 100 μg/mL).
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Iodine prophylaxis-the protective factor against stomach cancer in iodine deficient areas
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Epidemic strength of cardia and distant stomach cancer in the high risk region of esophageal cancer and their implication to edo
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Methylenetetrahydrofolate reductase genotypes, dietary habits and susceptibility to stomach cancer
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A case control study on risk factors for stomach cancer in urban Shanghai
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The expression of PCNA and EGFr in chemically induced hepatocellular carcinoma of liver and squamous cell carcinoma of stomach in rats were immunohistochemically observed.
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Role of gastric bypass in patients with unresectable advanced carcinoma of stomach
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Investigation of patho-histological spreading form of carcinoma of stomach
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Problems in surgery for early carcinoma of stomach and so-called open gastrectomy
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Report on early carcinoma of stomach, less than 39 year old
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