The serum PGⅠ,PGⅡ levels of 40 stomach cancer patients and 40 normal subjects were measured. Results showed that concentration of serum PGⅠ of cancer patients was lower than that in normal serum(P<0.001),PGⅡ was higher(P<0.01),and PGⅠ/PGⅡ was lower(P<0.001) than that in normality.
The results showed that obviously positive reactions appeared in cells of breast carcinoma,liver carcinoma and colon carcinoma,weakly positive reactions in stomach carcinoma,squamous epithelioma,lung carcinoma and uterocervix carcinoma,but negative in all non epithelingenic malignant tumor.
Reversal of multidrug resistance of gastric cancer cells by downregulation of CIAPIN1 with CIAPIN1 siRNA
The overexpression of a new cytokine-induced apoptosis inhibitor 1 (CIAPIN1) gene has been shown previously to promote a multidrug resistant phenotype in gastric cancer cells through the upregulation of MDR1 and MRP1.
CIAPIN1 siRNA could significantly downregulate the expression of Bcl-2, and upregulate the expression of Bax, but does not alter the expression of PTEN in gastric cancer cells.
These observations suggested that the siRNA constructs of CIAPIN1 we obtained could effectively downregulate the expression of CIAPIN1 and reverse the resistant phenotype of gastric cancer cells.
Further study of the biological functions of CIAPIN1 may be helpful for understanding the mechanisms of multidrug resistance of gastric cancer and in developing possible strategies to treat gastric cancer.
Human hematopoietic cell K562, human melenonla cell LiBr and human stomach cancer cells were exposed to ultrasound (US, 1.75 W/cm2, 1.4, 2.16 and 2.4 MHz)in vitro in the presence or absence of hematoporphyrin (Hp, 100 μg/mL).
Iodine prophylaxis-the protective factor against stomach cancer in iodine deficient areas
Epidemic strength of cardia and distant stomach cancer in the high risk region of esophageal cancer and their implication to edo
Methylenetetrahydrofolate reductase genotypes, dietary habits and susceptibility to stomach cancer
A case control study on risk factors for stomach cancer in urban Shanghai