Results The detection rate of gastric ulcer,duodenal ulcer,and gastric cancer by gastroscopy during the period of January 2004 to December 2005(5.53%,10.07% and 4.03%,respectively) was significantly lower than that during the period of January 1994 to December 1995(8.17%,11.21% and 6.21%,respectively,P<0.05).
Methods: 114 patients with gastroduodenal diseases (59 chronic gastritis, 38 gastroduodenal ulcer and 17 stomach cancer) and 164 healthy controls in Chinese Han population were genotyped for LT α Nco Ⅰ、 AspH Ⅰ gene polymorphisms by PCR RFLP method.
Reversal of multidrug resistance of gastric cancer cells by downregulation of CIAPIN1 with CIAPIN1 siRNA
The overexpression of a new cytokine-induced apoptosis inhibitor 1 (CIAPIN1) gene has been shown previously to promote a multidrug resistant phenotype in gastric cancer cells through the upregulation of MDR1 and MRP1.
CIAPIN1 siRNA could significantly downregulate the expression of Bcl-2, and upregulate the expression of Bax, but does not alter the expression of PTEN in gastric cancer cells.
These observations suggested that the siRNA constructs of CIAPIN1 we obtained could effectively downregulate the expression of CIAPIN1 and reverse the resistant phenotype of gastric cancer cells.
Further study of the biological functions of CIAPIN1 may be helpful for understanding the mechanisms of multidrug resistance of gastric cancer and in developing possible strategies to treat gastric cancer.
Human hematopoietic cell K562, human melenonla cell LiBr and human stomach cancer cells were exposed to ultrasound (US, 1.75 W/cm2, 1.4, 2.16 and 2.4 MHz)in vitro in the presence or absence of hematoporphyrin (Hp, 100 μg/mL).
Iodine prophylaxis-the protective factor against stomach cancer in iodine deficient areas
Epidemic strength of cardia and distant stomach cancer in the high risk region of esophageal cancer and their implication to edo
Methylenetetrahydrofolate reductase genotypes, dietary habits and susceptibility to stomach cancer
A case control study on risk factors for stomach cancer in urban Shanghai