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转基因鼠     
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  transgenic mice
     all P<0.05.And the serum cholesterol levels in the 12-month h-APP (2.38±0.37) mmol/L and h-apo E4 (2.67±0.59 )mmol/L transgenic mice were higher than that in control mice (2.16±0.50) mmol/L (P<0.05 ) as well.
     12月龄h-APP转基因鼠和h-apo E_4转基因鼠血清胆固醇水平[h-APP鼠(2.38±0.37)mmol/L,h-apo E_4鼠(2.67±0.59) mmol/L]均明显高于同龄对照组鼠[(2.16±0.5)mmol/L](P<0.05)。
短句来源
     Transgenic Mice of Human ApoE_(7-2) and ApoE_(7-3)
     人ApoE转基因小鼠与TGE_(7-2) TGE_(7-3)转基因鼠系的建立
短句来源
     Retinal degeneration in transgenic mice induced by oncostatin M through gp130/OSMRβ receptor
     制瘤素通过其受体gp130/OSMRβ诱发转基因鼠视网膜变性
短句来源
     Establishment of BAC Mediated Transgenic Mice Containing 97 kb β-globin Gene Cluster
     BAC介导的含97kb人β类珠蛋白基因簇转基因鼠模型的建立
短句来源
     The content of the DA and 5-HT in APP695 transgenic mice increased 38.9% and 45.8% respectively compared with control group.
     APP695转基因鼠大脑皮层中 DA和 5 -HT平均含量分别比对照鼠升高 3 8.9%和 45 .8%。
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  transgenic mouse
     Establishment of the Mutant Human ApoAⅠ/CⅢ/AⅣ/AⅤ Gene Cluster Transgenic Mouse Mediated by BAC and Comparative Studies with the Intact ApoAⅠ Cluster Transgenic Mice
     BAC介导ApoCⅢ增强子删除的人载脂蛋白apoAⅠ/CⅢ/AⅣ/AⅤ基因簇突变株转基因鼠系的建立以及其与完整基因簇转基因小鼠的比较研究
短句来源
     ③The mean gray value of LMP1: The expression levels of LMP1 in the transgenic mouse were lowest in nasopharyngeal tissue(106.75±19.57), and secondly were in nasal cavit, esophagus epithelia, lung, stomach, and were higher in large intestine(152.29±12.17), liver(134.98±17.79) and spleen(158.35±10.75).
     ③转基因鼠和对照鼠不同组织部位中潜伏膜蛋白1基因表达的平均灰度值:转基因鼠鼻咽部平均灰度值最低(106.75±19.57),其次为鼻腔、食道、肺、胃,而在大肠、肝、脾中表达水平较高(152.29±12.17,134.98±17.79,158.35±10.75)。
短句来源
     Objective To investigate the role of h-apolipoproteins E_4 (apo E_4) and amyloid protein precursor(APP) in lipoprotein metabolism and Alzheimer's disease in h-apo E_4/h-APP transgenic mouse model.
     目的建立h载脂蛋白E_4(h-apo E_4)/h淀粉样前体蛋白(h-APP)双转基因鼠模型,探讨人apo E_4及人突变APP基因在脂质代谢及早老痴呆疾病(AD)中的作用。 方法将h-apo E_4转基因鼠及h-APP转基因鼠交配,建立h-apo E_4/h-APP双转基因鼠
短句来源
     The identification of bovine lactoglobulin-β-tPA transgenic mouse by PCR method
     PCR检测牛β-乳球蛋白-tPA转基因鼠
短句来源
     The Aβ plaques in Tg2576 transgenic mouse brain were labeled with the antisera.
     抗血清可识别结合Tg2 5 76转基因鼠脑组织的Aβ斑。
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  transgenic mice model
     These suggested that the gene construct contained Pinv and gene E6/7 is successful, the transgenic mice model will become strongly useful tool for exploring the related vaccine and studing the relationship of Rb, p53 genes and E6/7 gene.
     该阳性转基因鼠系的成功建立为本实验室深入研究HPVE_(6/7)致瘤过程中与p53、Rb基因的相关作用,HPVE_(6/7)相关治疗性疫苗的研制提供了实验平台。
短句来源
     Objective To delete IL-11 receptor a chain gene from the Bacterial Artificial Chromosome (BAC) chimerie DNA by RecA protein mediated homologous recombination method and establish the transgenic mice model containing whole β-globin gene cluster.
     目的 利用RecA蛋白介导的同源重组的方法,修饰含全长人β珠蛋白基因簇及一段IL-11受体α链基因的(?) C(细菌人工染色体)克隆,建立只包括全长人β珠蛋白基因簇的转基因鼠模型。
短句来源
  “转基因鼠”译为未确定词的双语例句
     The spontaneous alternation behavior was decreased in h-apo E_4/h-APP (0.74±0.03)%,h-APP (0.80±0.05 ) %,and h-apo E_4 mice (0.72±0.07)% in comparison with control mice (0.95±0.06)% (P<0.01 or P<0.05).
     转基因鼠自发变换行为[h-apo E_4/h-APP(0.74±0.03)%,h-APP(0.80±0.05)%,h-apo E_4(0.72±0.07)%]与对照组鼠[(0.95±0.06)%]的差异有统计学意义(P<0.01或<0.05)。
短句来源
     Kidney Gene Expression Changes of Human ApoE_4-Transgenic Mice by cDNA Array Analysis
     cDNA微阵列分析人apoE_4转基因鼠肾脏基因表达谱的变化
短句来源
     Cu/ZnSOD1, APP, βCTFand Aβ in serum and brain of Tg mice were measured by western blot.
     Western印迹法定量分析转基因鼠血清及人脑Cn/ZnSOD1、APP及Aβ蛋白含量。
     Results The products of PCR in double reporter Z/EG transgenic adult mice were 631 bp band.
     结果双报告Z/EG转基因鼠所获PCR产物为631bp;
短句来源
     Among 125 mice, three apoE7 founders tg1, tg2 and tg3, two apoE4 founders tg4 and tg5 were screened by Southern blot analysis.
     Southern杂交鉴定得到人apoE_7首建鼠3只:tg1、tg2、tg3和人apoE_4首建鼠2只:tg4、tg5。 通过自交传代进一步建立相应的F1-F5代转基因鼠系。
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  transgenic mice
A study of recombinant human lactoferrin secreted in milk of transgenic mice
      
Analysis of the maintenance of pCI.ARS-neo and pCI.ori-neo in transgenic mice and in cultured immortalized human T cells revealed the interplay of transcription and replication, as the CMV element suppressed autonomous replication of both plasmids.
      
Examples are given for utilization of conditionally immortal cells obtained in vivo from tissues of transgenic mice and rats carrying the gene of mutant T-antigen tsA58 SV40.
      
Analysis of transfer of microinjected zygotes in production of transgenic mice
      
The data on transfer of mouse eggs microinjected with DNA during production of transgenic mice were analyzed.
      
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  transgenic mouse
The cardioprotective role of Trx 1 is further confirmed with transgenic mouse hearts overexpressing Trx 1.
      
A total of four transgenic mouse lines were obtained, in three of which the vector was integrated into genes active during embryogenesis.
      
To study the mechanisms of such instability, two transgenic mouse lines and 11 clones of transfected F9 mouse embryonic teratocarcinoma cells were obtained with the 3.8-kb repetitive unit (Sat) of Bos taurus satellite DNA IV.
      
G-CSF of transgenic mouse milk was shown to stimulate the formation and growth of granulocyte-containing colonies in human umbilical blood cell culture and be close or identical in physiological activity to the natural human G-CSF.
      
These observations are associated with an increased atrial vulnerability.????The Cx40 deficient mouse provides a good example of the relevance of transgenic mouse models to clarify the mechanisms of arrhythmogenesis.
      
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  transgenic rat
To examine further the role of aldose reductase, we have overexpressed the human enzyme in a transgenic rat model.
      
No effect of overexpression of aldose reductase on renal structure nor on urinary excretion of β2-microglobulin and N-acetyl-β-d-glucosaminidase was observed in this transgenic rat model.
      
Neuroactive Steroid Levels in a Transgenic Rat Model of CMT1A Neuropathy
      
A transgenic rat model overexpressing the mouse renin gene, TGR(mREN2)27 has been shown to progress profound cardiac hypertrophy, possibly due to a monogenetic disorder.
      
Functional characterization of the human atrial essential myosin light chain (hALC-1) in a transgenic rat model
      
更多          
  transgenic mice model
Use of transgenic mice model for understanding the placentation: towards clinical applications in human obstetrical pathologies
      
High priority must be given to replication of prior studies that indicate adverse effects, such as the transgenic mice model mentioned above.
      
  其他


In this study, the fusion was made between the MT-I promoter and thegenomic DNA of bovine growth hormone (bGH), then fusion was made again betweenthe above structure and enhancer of simian virus 40 genomic DNA in close (pSVCATL-BGH) and 2.3 kb distance (pSV2LBGH) forms. Another fusion was made between thepromoter, enhancer of immunoglobulin and bGH cDNA (pSLB111). Then, the threeforms of construct were microinjected into fertilized eggs of ICR, KB, and C57BL/6J strain mice. During this study, 2129 fertilized...

In this study, the fusion was made between the MT-I promoter and thegenomic DNA of bovine growth hormone (bGH), then fusion was made again betweenthe above structure and enhancer of simian virus 40 genomic DNA in close (pSVCATL-BGH) and 2.3 kb distance (pSV2LBGH) forms. Another fusion was made between thepromoter, enhancer of immunoglobulin and bGH cDNA (pSLB111). Then, the threeforms of construct were microinjected into fertilized eggs of ICR, KB, and C57BL/6J strain mice. During this study, 2129 fertilized eggs were injected and transferred to 74pseudopregnant recipients, in which 30 became gestation. 27 of 30 pregnant mice gavebirth to 116 F_0 mice, and 13 dead fetuses were got from other 3 pregnant mice. DNAwas extracted from F, mouse tail, then to assay the integgration of bGH gene in thegenomes of these mice through dot and southern blot. It has shown that 27 F_0 mice(pSV2LBGH: ICR, 5; KB, 7; pSVCATLBGH: ICR, 5; KB, 8; C57BL/6J, 2) werepositive, and that 9 of 13 dead fetuses of different developmental stage were positivenessof bGH gene integration. After 30 days of birth date, all 27 positive mice were inducedwith the addition of 75 mmol/L ZnSO_4 in their feeding water, then to analyze them. Allthree constructs were integrated into the mouse genomes with single site and head to tailform; 18 of 27 bGH transgenic mice had expressed bGH at different levels, which was infunction of the copy numbers of bGH gene integrated in mouse genomes. 4 mice who ex-pressed high level of bGH in their liver showed an apparent "promoting growth effect",which are 0.8-1.2 times bigger than normal mice. There was no direct relation between"promoting growth effect" and the level of bGH expression; other 14 mice who ex-pressed bGH at different levels had weight similiar to normal ones. All 18 mice ex-pressed bGH had higher expression after induction of Zn~(2+) and Cd~(2+). The bGH gene hada tissue specific expression in these transgenic mice, mainly expressed in liver, heart andtestis. It showed that only those who had a liver specificity and higher expression levelcould have the "promoting growth effect", this was relized through the activation of in-sulin-like growth facter-Ⅰ by bGH in the liver.

把小鼠的金属疏基组氨酸三甲内盐基因(MT-I)的启动子与牛生长激素(bGH)基因组DNA重组,再以紧邻(pSVCATLBGH)和相差2.3kb的距离(pSV2LBGH)两种形式与猴空泡病毒(SV40)的增强子融合;还有一种是把免疫球蛋白的启动子和增强子与不含内含子的牛生长激素基因融合(pSLBlll).把上述3种结构的重组子显微注射到ICR、昆明白(KB)和C57BL 3种品系供体鼠受精卵中,接着移植到昆明白假孕受体鼠的输卵管,其培育出116只F_0代鼠和13只死胎,经Southern Blot检测,其中27只(pSV2LBGH:ICR 5只;KB7只;pSVCATLBGH:ICR5只;KB8只;C57BL 2只)鼠的基因组中整合有bGH基因;另由pSLBlll重组子做外源基因导入受精卵所得到的13只不同发育阶段的死胎中有9只整合有pSLBlll重组子.对27只阳性鼠于出生后30d开始在饮水中加75mmol/L ZnSO_4进行诱导.结果表明,3种结构形式的bGH基因重组子均以头尾相连的串联体形式,以单点整合于鼠染色体中;所育成的27只bGH转基因鼠有18只不同程度表达了bGH;表达水平与整合的b...

把小鼠的金属疏基组氨酸三甲内盐基因(MT-I)的启动子与牛生长激素(bGH)基因组DNA重组,再以紧邻(pSVCATLBGH)和相差2.3kb的距离(pSV2LBGH)两种形式与猴空泡病毒(SV40)的增强子融合;还有一种是把免疫球蛋白的启动子和增强子与不含内含子的牛生长激素基因融合(pSLBlll).把上述3种结构的重组子显微注射到ICR、昆明白(KB)和C57BL 3种品系供体鼠受精卵中,接着移植到昆明白假孕受体鼠的输卵管,其培育出116只F_0代鼠和13只死胎,经Southern Blot检测,其中27只(pSV2LBGH:ICR 5只;KB7只;pSVCATLBGH:ICR5只;KB8只;C57BL 2只)鼠的基因组中整合有bGH基因;另由pSLBlll重组子做外源基因导入受精卵所得到的13只不同发育阶段的死胎中有9只整合有pSLBlll重组子.对27只阳性鼠于出生后30d开始在饮水中加75mmol/L ZnSO_4进行诱导.结果表明,3种结构形式的bGH基因重组子均以头尾相连的串联体形式,以单点整合于鼠染色体中;所育成的27只bGH转基因鼠有18只不同程度表达了bGH;表达水平与整合的bGH基因拷贝数成正比,其中在肝脏有较高表达的4只鼠呈现明显的促生长效应,它们比正常鼠大0.8~1.2倍,促生长效应与鼠体内bGH的表达水平无对应关系;另外14只表达了bGH的小鼠与正常小鼠大小类似.所有18只小鼠bGH的表达水平均受Zn~(2+)和Cd~(2+)?

In this study,SV40 enhancer was fused to the upstream of

把SV40的增强子序列以紧邻(pSVCATLBGH)和相距2.3kb的距离克隆到小鼠金属巯基组氨酸三甲内盐基因(MT-I)启动子的上游,用以研究了在体内(invivo)环境下原核基因的增强于对真核基因转录调控的影响,以及增强子与启动子的距离对增强于增强转录效率的影响。在建立了pSVCATLBGH和pSV2LBGH两种转基因结构的不同种系的转基因鼠后,通过分析ICR、KB(昆明白)和C57BL3种种系的pSVCATLBGH转基因鼠的6种主要器官中的CAT活性,证明SV40增强子可以增强真核基因──CAT基因的转录效率而无种属及组织特异性;通过比较ICR和昆明白(KB)两种种系的pSVCATLBGH和pSV2LBGH转基因鼠的心脏和肝脏中bGHmRNA水平,证明在转基因鼠体内,在2.3kb距离内,SV40增强子对由MT-I启动子启动的真核基因──bGH基因的转录效率的增强效果无明显差异。

hirty-five cases of cancer

研究了35例乙型肝炎病毒(HBV)表面抗原基因转基因鼠发生的肝细胞癌和10例癌旁肝组织C-myc、H-ras、TGF-α、肝生长因子(HGF)、C-met及胰岛素样生长因子-Ⅱ(IGF-Ⅱ)基因结构或表达的异常,发现51%的肝癌组织及10%的癌旁组织有IGF-Ⅱ的表达,而其它基因无结构或表达的异常。探讨了乙型肝炎病毒表面抗原肝细胞表达诱发肝癌的分子病理基础。

 
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