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纤维癌
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  “纤维癌”译为未确定词的双语例句
     The expression of the E-Selectin and SLe-X breast cancer tissues was significantly higher than in adjacent normal and benign tissues'(P<0.01) and so was the expression of SLe-X(P<0.01) but not E-Selectin in the metastasis group(P>0.05).
     E-选择素及sLe-X在乳腺癌组织中的表达显著高于癌旁组织及乳腺纤维癌中的表达(P<0.01); 有淋巴结转移的乳腺癌组织sLe-X的表达高于无转移组(P<0.01),而E-Selectin在两组间的表达差异无统计学意义(P>0.05)。
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     and the carcinoma nest surrounded by reticulated fibers presented an alveolar structure.
     网状纤维呈蜂窝状围绕巢。
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     40 patients with carcinoma of nasopharynx were subjected to the examination of general fibreoptic endoscopy.
     常规纤维鼻咽镜检查鼻咽40例。
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     AROMATIC POLYAMIDE FIBER
     芳香族聚酰胺纤维
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     Gastric-ulcer Cancer
     胃溃疡
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     Special Style Fibres
     特殊风格纤维
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  fibrocarcinoma
In flow cytometric analysis using rhodamine 123 as an artificial substrate, Rg3 promoted accumulation of rhodamine 123 in drug-resistant human fibrocarcinoma KBV 20C cells in a dose-dependent manner, but it had no effect on parental KB cells.
      
  carcinoma fibrosum
Ein Beitrag zur Lehre vom Carcinoma fibrosum des Magens
      
über die Indikationen zur Gastrektomie und die besonderen Verh?ltnisse beim Scirrhus ventriculi (Carcinoma fibrosum)
      


Objective To study the early and late changes in mRNA expression in macrophages in response to lipopolysaccharide (LPS) with a cDNA microarray approach using the Clontech Atlas microarray . Methods mRNA was isolated from unstimulated control and LPS stimulated murine peritoneal macrophages at 2 hours and 24 hours poststimulation,converted to 33 P radiolabeled cDNA, and hybridized to mouse array membranes. Results In macrophages being stimulated for 2 hours, 69 out of 1 176 genes were found...

Objective To study the early and late changes in mRNA expression in macrophages in response to lipopolysaccharide (LPS) with a cDNA microarray approach using the Clontech Atlas microarray . Methods mRNA was isolated from unstimulated control and LPS stimulated murine peritoneal macrophages at 2 hours and 24 hours poststimulation,converted to 33 P radiolabeled cDNA, and hybridized to mouse array membranes. Results In macrophages being stimulated for 2 hours, 69 out of 1 176 genes were found to differ by over 3fold compared with the control. Among them 44 genes were upregulated and 25 genes were downregulated. In macrophages stimulated for 24 hours, 11 genes were upregulated and 26 genes were downregulated compared with the control. Only 8 genes were identified both at 2 hours and at 24 hours poststimulation. The expressions of many genes encoding transcription factor, cytokines,cell signaling modulators and apoptosis associated proteins were found to have changed. Some genes that were not previously linked to this model, such as bricabrac(BTB) and capncollar(CNC) homology 1(BACH1) , early growth response protein 2(EGR2), E47 interaction protein 1(EIP1), NgfiA binding protein 2 (NAB2), myeloblastosis oncogenelike protein(MYBL2), neurofibromatosis 1(NF1), ciliarry neurotropic factor(CNTF) and semaphorin 4A(Sema4A). Conclusion This study has allowed us to identify genes that may potentially be regulated by LPS at early and late phase in macrophages. These may contribute to better understanding of the mechanism underlying LPS or bacteria induced inflammatory and immune response following infection and trauma.

目的 利用 c DNA芯片技术分析内毒素活化的小鼠腹腔巨噬细胞早期和晚期基因表达 ,以更全面了解内毒素在感染、创伤反应中通过巨噬细胞介导的炎症和免疫反应。方法 以未刺激的和用 1mg/ L脂多糖 ( L PS)分别刺激 2 h(早期 )和 2 4 h(晚期 )的小鼠腹腔巨噬细胞制备 33P标记的 c DNA探针 ,并分别与小鼠 c DNA表达芯片 (含 1176个已知基因 )杂交。结果 巨噬细胞活化早期的 3倍差异表达基因为 6 9个 ,其中4 4个上调 ,2 5个下调 ;巨噬细胞活化晚期的 3倍差异表达基因中有 11个上调 ,2 6个下调 ;只有 8个基因同时出现于活化早期和晚期的差异表达基因中。许多转录因子、细胞内信号转导调节蛋白、炎症细胞因子和细胞凋亡相关基因的表达均发生了明显的调节变化。发现 BTB和 CNC同源 1( BACH1)、早期生长反应蛋白 2( EGR2 )、E4 7反应蛋白 1( EIP1)、Ngfi A结合蛋白 2 ( NAB2 )、成髓细胞白血病癌基因样蛋白 ( MYBL2 )、神经纤维癌蛋白基因 1( NF1)、睫状神经营养因子 ( CNTF)和 Sema4 A等一些以...

目的 利用 c DNA芯片技术分析内毒素活化的小鼠腹腔巨噬细胞早期和晚期基因表达 ,以更全面了解内毒素在感染、创伤反应中通过巨噬细胞介导的炎症和免疫反应。方法 以未刺激的和用 1mg/ L脂多糖 ( L PS)分别刺激 2 h(早期 )和 2 4 h(晚期 )的小鼠腹腔巨噬细胞制备 33P标记的 c DNA探针 ,并分别与小鼠 c DNA表达芯片 (含 1176个已知基因 )杂交。结果 巨噬细胞活化早期的 3倍差异表达基因为 6 9个 ,其中4 4个上调 ,2 5个下调 ;巨噬细胞活化晚期的 3倍差异表达基因中有 11个上调 ,2 6个下调 ;只有 8个基因同时出现于活化早期和晚期的差异表达基因中。许多转录因子、细胞内信号转导调节蛋白、炎症细胞因子和细胞凋亡相关基因的表达均发生了明显的调节变化。发现 BTB和 CNC同源 1( BACH1)、早期生长反应蛋白 2( EGR2 )、E4 7反应蛋白 1( EIP1)、Ngfi A结合蛋白 2 ( NAB2 )、成髓细胞白血病癌基因样蛋白 ( MYBL2 )、神经纤维癌蛋白基因 1( NF1)、睫状神经营养因子 ( CNTF)和 Sema4 A等一些以前未曾报道与 L PS诱导的巨噬细胞活化相关的基因。结论 采用 c DNA芯片技术了解内毒素诱导的巨噬细胞活化早期和晚期的综合基因表达信息 ,有助于更好地了解感染、创伤后细菌内毒素诱导的炎症免疫反应

Objective:To investigate the level of E-selectin and its ligand-sLe-X expression in breast carcinoma and its relation with differentiation,metastasis and prognosis.Methods:Immunohistochemistry was used to detect the rate of E-selectin and sLe-X in tumor tissues and adjacent normal tissues in 56 samples of breast cancer.A control group coinsisted of 20 patients with a benign breast tumor.Results:The positive rate of E-selectin and ligand-sLe-X in breast cancer tissues,adjacent normal tissues and benign tissues...

Objective:To investigate the level of E-selectin and its ligand-sLe-X expression in breast carcinoma and its relation with differentiation,metastasis and prognosis.Methods:Immunohistochemistry was used to detect the rate of E-selectin and sLe-X in tumor tissues and adjacent normal tissues in 56 samples of breast cancer.A control group coinsisted of 20 patients with a benign breast tumor.Results:The positive rate of E-selectin and ligand-sLe-X in breast cancer tissues,adjacent normal tissues and benign tissues were 82.14%(46/56)vs 73.21%(41/56),67.86%(38/56)vs 58.93%(33/56),and 15.00%(3/20)vs 30.00%(6/20),respectively.The expression of the E-Selectin and SLe-X breast cancer tissues was significantly higher than in adjacent normal and benign tissues'(P<0.01) and so was the expression of SLe-X(P<0.01) but not E-Selectin in the metastasis group(P>0.05).The expression of E-selectin in breast cancer was significantly higher in women with oestrogen receptor-negative tumors(P=0.001),poorly differentiated tumor(P=0.013),more advanced tumor node metastasis(TNM) stage(P=0.026) and the diameter of tumors(P=0.01).Univariate analysis showed that there may be an association between overexpression of E-selectin and a worse prognosis(P=0.027).Conclusions:E-Selectin and SLe-X play an collaborate role in the lymph metastasis and carcinogenesis of breast cancer.E-selectin as a potent marker may contribute to diagnosis of metastasis and prognosis for breast cancer patients.It may play an important role in targeting and individualized treatment of breast cancer.

目的:探讨乳腺癌组织中E-选择素(E-selectin)及其配体sLe-X(SialylLewis-X)的表达状况及其与肿瘤分化、转移及预后的关系。方法:采用免疫组化技术检测56例乳腺癌及癌旁组织中E-Selectin和sLe-X的表达,分析其表达水平与淋巴转移及临床病理特征之间的关系。20例乳腺纤维瘤标本为对照。结果:E-选择素和sLe-X在乳腺癌组织、癌旁组织、乳腺纤维瘤中阳性表达率分别为82.14%(46/56)、67.86%(38/56)、15.00%(3/20);73.21%(41/56)、58.93%(33/56)、30.00%(6/20)。E-选择素及sLe-X在乳腺癌组织中的表达显著高于癌旁组织及乳腺纤维癌中的表达(P<0.01);有淋巴结转移的乳腺癌组织sLe-X的表达高于无转移组(P<0.01),而E-Selectin在两组间的表达差异无统计学意义(P>0.05)。乳癌组织中E-选择素的表达与ER特征(P=0.001)、肿瘤分期(P=0.026)、肿瘤分化程度(P=0.013)、肿瘤直径(P=0.01)明显相关。单因素分析显示E-选择素表达状态与生存率相关(P=0.027)。结...

目的:探讨乳腺癌组织中E-选择素(E-selectin)及其配体sLe-X(SialylLewis-X)的表达状况及其与肿瘤分化、转移及预后的关系。方法:采用免疫组化技术检测56例乳腺癌及癌旁组织中E-Selectin和sLe-X的表达,分析其表达水平与淋巴转移及临床病理特征之间的关系。20例乳腺纤维瘤标本为对照。结果:E-选择素和sLe-X在乳腺癌组织、癌旁组织、乳腺纤维瘤中阳性表达率分别为82.14%(46/56)、67.86%(38/56)、15.00%(3/20);73.21%(41/56)、58.93%(33/56)、30.00%(6/20)。E-选择素及sLe-X在乳腺癌组织中的表达显著高于癌旁组织及乳腺纤维癌中的表达(P<0.01);有淋巴结转移的乳腺癌组织sLe-X的表达高于无转移组(P<0.01),而E-Selectin在两组间的表达差异无统计学意义(P>0.05)。乳癌组织中E-选择素的表达与ER特征(P=0.001)、肿瘤分期(P=0.026)、肿瘤分化程度(P=0.013)、肿瘤直径(P=0.01)明显相关。单因素分析显示E-选择素表达状态与生存率相关(P=0.027)。结论:E-选择素和SLe-X协同介导了乳腺癌的发生发展及淋巴结转移。E-选择素可能是预测乳腺癌转移和预后的分子标志。

 
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