Conclusion Successful construction of mouse B7-H1 lentivirol expression vector and expression of its functional fusion protein based further investigation of the role of B7-H1 in immune tolerance,autoimmune disease and tumor immune escape.
Background and ObjectiveMyasthenia gravis (MG) is one of autoimmune diseases, which is mainly mediated by the effect of the acetylcholine receptor antibody (AchRAb) against acetylcholine receptor (AchR) on the postsynaptic membrane of the neuromuscular junction (NMJ).
The autoantibodies could exist in many kinds of diseases, including PBC, and various systemic autoimmune dis-eases. Prevalence of the autoantibodies in PBC patients was 39.58%, which was significantly higher than that in other systemic autoimmune diseases patients (X2=134, P<0.01) and other liver diseases patients (X2=109, P< 0.01), and their specificity for PBC was 98.35%.
CTLA-4Ig and anti-CTLA-4 monoclonal antibody are two molecules that may play an important role on treatment of autoimmunity disease,transplant repel and tumor,the potential of which has been demonstrated in animal experiment and clinical practice.
Here, we intend to unravel the phenomenon of the alteration of endothelial cells' function in systemic autoimmunity disease and how epigallocatechin gallate(EGCG), the main componect of Catechins, regulates the function of vascular endothelial growth factor( VEGF).
The prevalence of autoimmune disorders other than liver in AIH、PBC、PSC and PBC-AIH overlap syndrome were 47%、11%、27%and 24%respectively and with high prevalence of auto-antibody in these autoimmune hepatic diseases.
Background: Autoimmune thyroid diseases (AITD), including Graves disease (GD), Hashimoto's thyroiditis (HT), idiopathic myxedema (IM), postpartum thyroiditis (PPT), and thyroid-associated orbitopathy (TAO), are organ-specific autoimmune diseases. AITD are the most common autoimmune disorders in population, affecting between 2% and 4% of women and up to 1% of men.
The development of lupus-like autoimmune disease of MRL/MpJ-lpr mice is an experimental model for study of autoimmune pathologies and immunopathogenesis.
Multiple sclerosis is a chronic inflammatory, putatively autoimmune disease characterized by multifocal demyelination in the central nervous system.
Systemic lupus erythematosus (SLE) is an autoimmune disease which occurs in over 80% in women during childbearing years.
The association with thymoma and raised AChR antibody suggests that this syndrome represents a unique type of autoimmune disease, in which antibodies against the AChR facilitate rather than inhibit cholinergic action.
The occurrence of a chronic inflammatory reaction in one of the two patients supports the idea that an autoimmune disease against GABA-ergic neurons may be involved in SMS.
The intermediate filament protein vimentin is a potential target antigen for autoantibodies in some infectious and autoimmune diseases.
We measured the level of anti-vimentin antibodies in patients with systemic autoimmune diseases (n=42), healthy blood donors (n=58), and patients with acute inflammation and showing anti-vimentin immunofluorescence (n=50).
There were no differences between the levels of anti-vimentin antibodies between patients with systemic autoimmune diseases and healthy individuals.
At the same time it is becoming apparent that some remedies usually used to treat somatic and psychic disorders also have immunomodulating properties, and may help manage multiple sclerosis and other autoimmune diseases.
Objective: Heat shock proteins (hsps) have been shown to be important antigens in a number of autoimmune diseases.