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   自身免疫性疾病 在 生物学 分类中 的翻译结果: 查询用时:0.068秒
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自身免疫性疾病     
相关语句
  autoimmune disease
    Conclusion:There could be important significance to further prove AS is an autoimmune disease that is benefit for diagnosis,treatment and prevention of AS.
    结论 :进一步证明AS是一种自身免疫性疾病 ,对于AS的诊断、治疗和预防具有重要意义
短句来源
    Conclusion The recombinant adenoviruses pAd-mB7-H4 was successfully generated and the functional mB7-H4 expression on the B16F10 transfected with pAd-mB7-H4 was detected which firmly based the further study on the organ transplatation,autoimmune disease and mechanism of immune evasion in cancer research.
    结论成功构建了mB7-H4重组腺病毒,转染B16F10细胞后表达出有活性的B7-H4蛋白,为进一步研究B7-H4分子在器官移植、自身免疫性疾病以及肿瘤逃逸机制中的作用奠定了基础。
短句来源
    CONCLUSION The results confirmed that pEGFP-c1-IP-10 fusion gene can be expressed in NIH 3T3 cell,which provides the basis as a DNA vaccine for studying the therapy of autoimmune disease(AID).
    结论证实IP-10基因可在NIH 3T3细胞中表达,为将其作为DNA疫苗治疗自身免疫性疾病的研究奠定了基础。
短句来源
    The Study of the Nonspecific Immunoreactivity of Histone with Some Monoclonal Antibodies: the Research on Pathoge-nesis of Autoimmune Disease
    组蛋白与某些单克隆抗体发生非特异性免疫反应的研究—自身免疫性疾病发病机理探讨
短句来源
    (4) PTA1has a close relationship with such diseases as platelet functionabnormal, autoimmune disease, graft versus host reaction, virusinfection and tumor.
    与血小板功能异常、自身免疫性疾病、移植物抗宿主反应、病毒感染性疾病以及肿瘤等疾病的发病机制有着密切的关系。
短句来源
更多       
  autoimmune diseases
    Autoimmune diseases are induced by the immune responses to self-antigens, which can impaire the homologous organ and cause the function obstacles of them.
    自身免疫性疾病是因机体免疫系统对自身成分发生免疫应答而导致相应组织器官甚至全身性的损伤以及功能障碍的一类疾病。
短句来源
    Therefore, the construction of OX40L transfected cells, the obtaining of OX40L agnostic or inhibitory reagents and investigation of their effects on OX40/OX40L signal transduction may have significant theoretic and clinical values in tumor, transplant rejection and autoimmune diseases.
    因此,OX40L转基因细胞的构建、OX40L分子的激动剂或拮抗剂的研制及其在OX40/OX40L信号传导和调节中的作用的研究将在肿瘤、移植排斥反应、自身免疫性疾病中具有重要的理论研究和临床应用价值。
短句来源
    The reactivity of histones with some MAbs reveals the possible pathogenesis of anti-histones antibody production in autoimmune diseases.
    组蛋白与某些单克隆抗体发生的交叉反应性揭示了在自身免疫性疾病中抗组蛋白自身抗体产生的可能致病原因。
短句来源
    Five types of anti-nuclear antibodies(IgG, IgE, IgD, IgA, IgM) from 39 patients with autoimmune diseases were examined by immunocytochemistry microwave-streptavidin perroxidase(M W-SP)method.
    用免疫细胞化学微波-SP法(MW-SP法)检测了39例自身免疫性疾病患者的5种抗核抗体(IgG、IgE、IgD、IgA、IgM)。
短句来源
    Results: The determinants of Ro/SSA existed on aa 100~190 and 191~300. Conclusion: The antigen deriving mechanism plays an important role in the pathogenesis of autoimmune diseases.
    结果: Ro/SSA(Mr= 60 000)的抗原优势决定簇主要存在于100~190位和191~300位,不同患者、不同病程抗原优势决定簇有所不同。 结论:抗原驱动机制在自身免疫性疾病的发病中起重要作用。
短句来源
更多       
  auto immune diseases
    Autoimmune diseases are induced by the immune responses to self-antigens, which can impaire the homologous organ and cause the function obstacles of them.
    自身免疫性疾病是因机体免疫系统对自身成分发生免疫应答而导致相应组织器官甚至全身性的损伤以及功能障碍的一类疾病。
短句来源
    Therefore, the construction of OX40L transfected cells, the obtaining of OX40L agnostic or inhibitory reagents and investigation of their effects on OX40/OX40L signal transduction may have significant theoretic and clinical values in tumor, transplant rejection and autoimmune diseases.
    因此,OX40L转基因细胞的构建、OX40L分子的激动剂或拮抗剂的研制及其在OX40/OX40L信号传导和调节中的作用的研究将在肿瘤、移植排斥反应、自身免疫性疾病中具有重要的理论研究和临床应用价值。
短句来源
    The reactivity of histones with some MAbs reveals the possible pathogenesis of anti-histones antibody production in autoimmune diseases.
    组蛋白与某些单克隆抗体发生的交叉反应性揭示了在自身免疫性疾病中抗组蛋白自身抗体产生的可能致病原因。
短句来源
    Five types of anti-nuclear antibodies(IgG, IgE, IgD, IgA, IgM) from 39 patients with autoimmune diseases were examined by immunocytochemistry microwave-streptavidin perroxidase(M W-SP)method.
    用免疫细胞化学微波-SP法(MW-SP法)检测了39例自身免疫性疾病患者的5种抗核抗体(IgG、IgE、IgD、IgA、IgM)。
短句来源
    Results: The determinants of Ro/SSA existed on aa 100~190 and 191~300. Conclusion: The antigen deriving mechanism plays an important role in the pathogenesis of autoimmune diseases.
    结果: Ro/SSA(Mr= 60 000)的抗原优势决定簇主要存在于100~190位和191~300位,不同患者、不同病程抗原优势决定簇有所不同。 结论:抗原驱动机制在自身免疫性疾病的发病中起重要作用。
短句来源
更多       
  auto immune disease
    Conclusion:There could be important significance to further prove AS is an autoimmune disease that is benefit for diagnosis,treatment and prevention of AS.
    结论 :进一步证明AS是一种自身免疫性疾病 ,对于AS的诊断、治疗和预防具有重要意义
短句来源
    Conclusion The recombinant adenoviruses pAd-mB7-H4 was successfully generated and the functional mB7-H4 expression on the B16F10 transfected with pAd-mB7-H4 was detected which firmly based the further study on the organ transplatation,autoimmune disease and mechanism of immune evasion in cancer research.
    结论成功构建了mB7-H4重组腺病毒,转染B16F10细胞后表达出有活性的B7-H4蛋白,为进一步研究B7-H4分子在器官移植、自身免疫性疾病以及肿瘤逃逸机制中的作用奠定了基础。
短句来源
    CONCLUSION The results confirmed that pEGFP-c1-IP-10 fusion gene can be expressed in NIH 3T3 cell,which provides the basis as a DNA vaccine for studying the therapy of autoimmune disease(AID).
    结论证实IP-10基因可在NIH 3T3细胞中表达,为将其作为DNA疫苗治疗自身免疫性疾病的研究奠定了基础。
短句来源
    The Study of the Nonspecific Immunoreactivity of Histone with Some Monoclonal Antibodies: the Research on Pathoge-nesis of Autoimmune Disease
    组蛋白与某些单克隆抗体发生非特异性免疫反应的研究—自身免疫性疾病发病机理探讨
短句来源
    (4) PTA1has a close relationship with such diseases as platelet functionabnormal, autoimmune disease, graft versus host reaction, virusinfection and tumor.
    与血小板功能异常、自身免疫性疾病、移植物抗宿主反应、病毒感染性疾病以及肿瘤等疾病的发病机制有着密切的关系。
短句来源
更多       

 

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      autoimmune disease
    The development of lupus-like autoimmune disease of MRL/MpJ-lpr mice is an experimental model for study of autoimmune pathologies and immunopathogenesis.
          
    Multiple sclerosis is a chronic inflammatory, putatively autoimmune disease characterized by multifocal demyelination in the central nervous system.
          
    Systemic lupus erythematosus (SLE) is an autoimmune disease which occurs in over 80% in women during childbearing years.
          
    The association with thymoma and raised AChR antibody suggests that this syndrome represents a unique type of autoimmune disease, in which antibodies against the AChR facilitate rather than inhibit cholinergic action.
          
    The occurrence of a chronic inflammatory reaction in one of the two patients supports the idea that an autoimmune disease against GABA-ergic neurons may be involved in SMS.
          
    更多          
      autoimmune diseases
    The intermediate filament protein vimentin is a potential target antigen for autoantibodies in some infectious and autoimmune diseases.
          
    We measured the level of anti-vimentin antibodies in patients with systemic autoimmune diseases (n=42), healthy blood donors (n=58), and patients with acute inflammation and showing anti-vimentin immunofluorescence (n=50).
          
    There were no differences between the levels of anti-vimentin antibodies between patients with systemic autoimmune diseases and healthy individuals.
          
    At the same time it is becoming apparent that some remedies usually used to treat somatic and psychic disorders also have immunomodulating properties, and may help manage multiple sclerosis and other autoimmune diseases.
          
    Objective: Heat shock proteins (hsps) have been shown to be important antigens in a number of autoimmune diseases.
          
    更多          
      auto-immune disease
    High levels of natural IFNα are present in the blood of patients with auto-immune disease and correlate with disease activity.
          
    We review the literature reporting associations between IFNα and auto-immune disease and discuss possible mechanisms by which IFNα may contribute to the development of auto-immune disease.
          
    However, the anti-collagen positivity of two control samples from 3 patients already positive for antinuclear antibodies demonstrates that bovine collagen injections are contraindicated in auto-immune disease.
          
    All patients were less than 80 years of age, with no cachexia or auto-immune disease, and they were not taking immuno-active medications.
          
    This method was applied to human metaphase chromosomes, which were immunocytochemically stained with anti-DNA and anti-ribonucleoprotein antibodies, derived from patients with auto-immune disease.
          
    更多          
      auto immune diseases
    MacKay and Burnet3 categorize the auto immune diseases in several main groups.
          
    These include certain viral infections, auto immune diseases and pregnancy.
          
      其他


    The double immunodiffusion was applied to examine the nonspecific imm-unoreactivity of historic with some monoclonal antibodies. The monoclonal antibodies against C-reactive protein (CRP) were identified. Two different antigenic epitopes in CRP molecule were recognized by these monoclonal antibodies. Histonc is able to give rise to immune precipitation reaction on agarose gel with monoclonal antibodies against CRP, FN, TB, but is not with polyclonal antibodies against CRP, FN, TB and the sera from myeloma patients....

    The double immunodiffusion was applied to examine the nonspecific imm-unoreactivity of historic with some monoclonal antibodies. The monoclonal antibodies against C-reactive protein (CRP) were identified. Two different antigenic epitopes in CRP molecule were recognized by these monoclonal antibodies. Histonc is able to give rise to immune precipitation reaction on agarose gel with monoclonal antibodies against CRP, FN, TB, but is not with polyclonal antibodies against CRP, FN, TB and the sera from myeloma patients. The reactivity of histone with some monoclonal antibodies explains the possible pathogenesis of anti-histone antibody in autoimmune disease and indicated that histone has some immunoregulation.

    本文描述了应用免疫双扩散技术检查组蛋白与某些单克隆抗体发生非特异性免疫反应。对抗人C—反应性蛋白(CRP)4株单克隆抗体进行了鉴定,它们识别了CRP上不同的抗原决定簇。组蛋白能够与CRP,纤维连接蛋白(FN),结核杆菌的单抗腹水起免疫沉淀反应,但不与其多克隆抗体及骨髓瘤病人血清起反应。组蛋白能与某些单抗起反应,初步解释了在自身免疫性疾病中抗组蛋白抗体产生的可能机制,说明组蛋白在机体免疫中具有一定的免疫调节作用。

    The monoclonal antibody was obtained by injecting RA3 hybridoma cells into the abdominal cavity to develop the ascites and then purified by protein A sepharose 4B affinity column. The antibody then was subjected to modification by SPDP bifunctional reagent,and conjugated with the deglycosylated ricin A chain by reducing the latter molecule. The coupled immunotoxin RTA-RA3 was separated from the free antibody and free RTA by Sephadex G-150 column. In the SDS-PAGE gel, the reduced immunotoxin appeared in three...

    The monoclonal antibody was obtained by injecting RA3 hybridoma cells into the abdominal cavity to develop the ascites and then purified by protein A sepharose 4B affinity column. The antibody then was subjected to modification by SPDP bifunctional reagent,and conjugated with the deglycosylated ricin A chain by reducing the latter molecule. The coupled immunotoxin RTA-RA3 was separated from the free antibody and free RTA by Sephadex G-150 column. In the SDS-PAGE gel, the reduced immunotoxin appeared in three bands, 50K, 25K, and 30K, Corresponding to immunoglobulin heavy chain, light chain, and ricin A chain respectively. In vivo injection of the immunotoxin into the MRL/lpr and MRL/- .mice was done through tail vein, after 2 days the splenocytes were harvested and surface markers of the cells were investigated by flow cytometry. The results show that the immunotoxin RTA-RA3 can selectively clear the B220+ splenocytes, therefore, the new anti-B220+ immunotoxin is very promising in treatment of the autoimmune diseases.Further research is under progress.

    将抗B220单克隆抗体分泌克隆RA3注射至SCID小鼠腹腔以获取腹水,抗体经proteinA亲和层析柱提纯,再经SPDP双功能交联剂修饰后,与还原的去糖基蓖麻毒蛋白A链反应生成免疫毒素RTA-RA3.SephadexG150柱层析分离纯化此免疫毒素,在还原状态下可见到免疫球蛋白重链、轻链及另一条带RTA.免疫毒素体内注射,研究MRL/+和MRL/lpr小鼠脾细胞的淋巴细胞标志.实验表明:RTA-RA3对脾B220+细胞有显著抑制作用.提示这一免疫毒素可用于治疗自身免疫性疾病

    Various kinds of immunotoxin have been prepared with genetic engineering method.The most succcessful one among them is interleukin-2(IL-2) immunotoxin,which consists of IL-2 protein fused with pseudomonas exotoxin or diphtheria exotoxin. The IL-2 moiety in this type of immunotoxin acts as a targeting ingredient,so that to kill the target cells positive for IL-2 receptors. The IL-2 immunotoxin is being applied to treat transplantation rejections,autoimmune diseases and T cell lymphomas , etc. So far,a promising...

    Various kinds of immunotoxin have been prepared with genetic engineering method.The most succcessful one among them is interleukin-2(IL-2) immunotoxin,which consists of IL-2 protein fused with pseudomonas exotoxin or diphtheria exotoxin. The IL-2 moiety in this type of immunotoxin acts as a targeting ingredient,so that to kill the target cells positive for IL-2 receptors. The IL-2 immunotoxin is being applied to treat transplantation rejections,autoimmune diseases and T cell lymphomas , etc. So far,a promising therapeutic efficiency has been achieved during the Ⅰ/Ⅱ phase clinical trials.

    应用基因工程技术已研制出多种免疫毒素,IL-2免疫毒素是研究最为成功的例子之一,包括IL-2与绿脓杆菌外毒素的融合蛋白,IL-2与白喉毒素的融合蛋白等.这类毒素以IL-2为导向分子,IL-2受体阳性细胞为靶细胞,治疗移植排斥反应、自身免疫性疾病、T细胞淋巴瘤等疾病,在Ⅰ/Ⅱ期临床试验中已取得了较好的疗效.但是这类免疫毒素对人体均有较强的抗原性,使治疗时间和效果均受限制,为此研制了人源化的IL-2免疫毒素,能在体内外杀伤IL-2受体阳性细胞.

     
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