The Graves’disease(GD) is the organ-specific autoimmune disease which is mediated by T lymphocyte. B7-CD28/CTLA-4,the most important costimulatory molecule,is required for activation and proliferation of T cells. It has been suggested that B7-CD28/CTLA-4 plays a significant role in initiation,retaining,effection stages of dysimmunity in GD.
Here, we intend to unravel the phenomenon of the alteration of endothelial cells' function in systemic autoimmunity disease and how epigallocatechin gallate(EGCG), the main componect of Catechins, regulates the function of vascular endothelial growth factor( VEGF).
Background: Autoimmune thyroid diseases (AITD), including Graves disease (GD), Hashimoto's thyroiditis (HT), idiopathic myxedema (IM), postpartum thyroiditis (PPT), and thyroid-associated orbitopathy (TAO), are organ-specific autoimmune diseases. AITD are the most common autoimmune disorders in population, affecting between 2% and 4% of women and up to 1% of men.
The development of lupus-like autoimmune disease of MRL/MpJ-lpr mice is an experimental model for study of autoimmune pathologies and immunopathogenesis.
Multiple sclerosis is a chronic inflammatory, putatively autoimmune disease characterized by multifocal demyelination in the central nervous system.
Systemic lupus erythematosus (SLE) is an autoimmune disease which occurs in over 80% in women during childbearing years.
The association with thymoma and raised AChR antibody suggests that this syndrome represents a unique type of autoimmune disease, in which antibodies against the AChR facilitate rather than inhibit cholinergic action.
The occurrence of a chronic inflammatory reaction in one of the two patients supports the idea that an autoimmune disease against GABA-ergic neurons may be involved in SMS.
The intermediate filament protein vimentin is a potential target antigen for autoantibodies in some infectious and autoimmune diseases.
We measured the level of anti-vimentin antibodies in patients with systemic autoimmune diseases (n=42), healthy blood donors (n=58), and patients with acute inflammation and showing anti-vimentin immunofluorescence (n=50).
There were no differences between the levels of anti-vimentin antibodies between patients with systemic autoimmune diseases and healthy individuals.
At the same time it is becoming apparent that some remedies usually used to treat somatic and psychic disorders also have immunomodulating properties, and may help manage multiple sclerosis and other autoimmune diseases.
Objective: Heat shock proteins (hsps) have been shown to be important antigens in a number of autoimmune diseases.