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   自身免疫性疾病 在 皮肤病与性病 分类中 的翻译结果: 查询用时:0.585秒
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自身免疫性疾病     
相关语句
  autoimmune disease
    BP is an autoimmune disease, CD4 + Th cell are participated in both cell -mediated immune reaction and humoral - mediated immune reaction, therefore is limited by MHC class II gene which encode by HLA - D.
    BP作为一种自身免疫性疾病,无论是由细胞免疫介导还是由体液免疫介导,皆需要CD4~+Th细胞参与。 还要受到MHC-Ⅱ类分子的限制,MHC-Ⅱ类分子主要由HLA-D区编码。
短句来源
    A family history of vitiligo was present in 36(7.2%) patients. 4.6% patients had associated autoimmune disease. 17(3.4%) patients had associated halo nevi, compared to 9(0.9%) in the adults.
    儿童有阳性家族史者 3 6例 (7.2 % ) ,合并自身免疫性疾病占 4.6 % ,伴发晕痣 1 7例 (3 .4% ) ,而成人伴发晕痣仅为 0 .9% .
短句来源
    Results The results showed the peak of onset was 11 to 30 years old. Generalized vitiligo was in 38.9% patients. Autoimmune disease was showed in 5.7% vitiligo patients, and Family history of vitiligo was present in 4.8%.
    结果白癜风患者以11-30岁为高峰,泛发性者占38.9%,合并自身免疫性疾病者占5.7%,有家族史者占4.8%。
短句来源
    It is hypothesized to be an organ-specific autoimmune disease with genetic predisposition and an environmental trigger.
    斑秃的发病机制目前尚不清楚,多数学者认为斑秃是一种多基因遗传背景下的自身免疫性疾病
短句来源
    Removing these pathogenic lymphocytes is an exploration of treatment in the autoimmune disease.
    因此设法清除识别相关抗原的B和/或T淋巴细胞克隆,有可能达到治疗相关自身免疫性疾病的目标。
短句来源
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  autoimmune diseases
    Vitiligo associated with other autoimmune diseases:Polyglandular autoimmune syndrome types 3B~+ C and 4
    白癜风与其他自身免疫性疾病有关:多腺性自身免疫综合征3B~+ C型和4型
短句来源
    All patients were classic psoriasis vulgaris, excluded SLE pemphigus dermatomyositis and other autoimmune diseases. Any drugs affected immune function had not used in recent two months.
    所有思者均为临床症状典型的寻常型银屑病患者,排除红斑狼疮、天痢疮、皮肌炎、风湿性关节炎等自身免疫性疾病以及肿瘤和其它严重系统性疾患,并且就诊前两个月内未曾应用免疫抑制剂和皮质类固醇激素等影响全身免疫功能的药物。
短句来源
    A few patients are induced by psychological factors, and some accompanied by other autoimmune diseases such as disease of thyroid gland and vitiligo.
    易合并其它的自身免疫性疾病如甲状腺疾病、白癜风;
短句来源
    Cytotoxic T lymphocyte associated-4 (CTLA-4) has been reported to be an important negative regulator of autoimmune diseases.
    CTLA-4的基因变异或其表达障碍均可引起其功能改变,导致免疫负性调节作用减弱,可能引发自身免疫性疾病。 而CTLA-4基因的多态性可能通过改变CTLA-4蛋白的表达或功能而导致个体自身免疫性疾病的易患倾向不同。
短句来源
    The inherited nature of vitiligo and its frequent association with autoimmune diseases have prompted studies on the association between HLA and vitiligo.
    白癜风的遗传特性以及白癜风患者常常伴发其他自身免疫性疾病,促使国内外学者研究HLA与白癜风的相关性。
短句来源
更多       
  auto immune diseases
    Vitiligo associated with other autoimmune diseases:Polyglandular autoimmune syndrome types 3B~+ C and 4
    白癜风与其他自身免疫性疾病有关:多腺性自身免疫综合征3B~+ C型和4型
短句来源
    All patients were classic psoriasis vulgaris, excluded SLE pemphigus dermatomyositis and other autoimmune diseases. Any drugs affected immune function had not used in recent two months.
    所有思者均为临床症状典型的寻常型银屑病患者,排除红斑狼疮、天痢疮、皮肌炎、风湿性关节炎等自身免疫性疾病以及肿瘤和其它严重系统性疾患,并且就诊前两个月内未曾应用免疫抑制剂和皮质类固醇激素等影响全身免疫功能的药物。
短句来源
    A few patients are induced by psychological factors, and some accompanied by other autoimmune diseases such as disease of thyroid gland and vitiligo.
    易合并其它的自身免疫性疾病如甲状腺疾病、白癜风;
短句来源
    Cytotoxic T lymphocyte associated-4 (CTLA-4) has been reported to be an important negative regulator of autoimmune diseases.
    CTLA-4的基因变异或其表达障碍均可引起其功能改变,导致免疫负性调节作用减弱,可能引发自身免疫性疾病。 而CTLA-4基因的多态性可能通过改变CTLA-4蛋白的表达或功能而导致个体自身免疫性疾病的易患倾向不同。
短句来源
    The inherited nature of vitiligo and its frequent association with autoimmune diseases have prompted studies on the association between HLA and vitiligo.
    白癜风的遗传特性以及白癜风患者常常伴发其他自身免疫性疾病,促使国内外学者研究HLA与白癜风的相关性。
短句来源
更多       
  auto immune disease
    BP is an autoimmune disease, CD4 + Th cell are participated in both cell -mediated immune reaction and humoral - mediated immune reaction, therefore is limited by MHC class II gene which encode by HLA - D.
    BP作为一种自身免疫性疾病,无论是由细胞免疫介导还是由体液免疫介导,皆需要CD4~+Th细胞参与。 还要受到MHC-Ⅱ类分子的限制,MHC-Ⅱ类分子主要由HLA-D区编码。
短句来源
    A family history of vitiligo was present in 36(7.2%) patients. 4.6% patients had associated autoimmune disease. 17(3.4%) patients had associated halo nevi, compared to 9(0.9%) in the adults.
    儿童有阳性家族史者 3 6例 (7.2 % ) ,合并自身免疫性疾病占 4.6 % ,伴发晕痣 1 7例 (3 .4% ) ,而成人伴发晕痣仅为 0 .9% .
短句来源
    Results The results showed the peak of onset was 11 to 30 years old. Generalized vitiligo was in 38.9% patients. Autoimmune disease was showed in 5.7% vitiligo patients, and Family history of vitiligo was present in 4.8%.
    结果白癜风患者以11-30岁为高峰,泛发性者占38.9%,合并自身免疫性疾病者占5.7%,有家族史者占4.8%。
短句来源
    It is hypothesized to be an organ-specific autoimmune disease with genetic predisposition and an environmental trigger.
    斑秃的发病机制目前尚不清楚,多数学者认为斑秃是一种多基因遗传背景下的自身免疫性疾病
短句来源
    Removing these pathogenic lymphocytes is an exploration of treatment in the autoimmune disease.
    因此设法清除识别相关抗原的B和/或T淋巴细胞克隆,有可能达到治疗相关自身免疫性疾病的目标。
短句来源
更多       

 

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      autoimmune disease
    The development of lupus-like autoimmune disease of MRL/MpJ-lpr mice is an experimental model for study of autoimmune pathologies and immunopathogenesis.
          
    Multiple sclerosis is a chronic inflammatory, putatively autoimmune disease characterized by multifocal demyelination in the central nervous system.
          
    Systemic lupus erythematosus (SLE) is an autoimmune disease which occurs in over 80% in women during childbearing years.
          
    The association with thymoma and raised AChR antibody suggests that this syndrome represents a unique type of autoimmune disease, in which antibodies against the AChR facilitate rather than inhibit cholinergic action.
          
    The occurrence of a chronic inflammatory reaction in one of the two patients supports the idea that an autoimmune disease against GABA-ergic neurons may be involved in SMS.
          
    更多          
      autoimmune diseases
    The intermediate filament protein vimentin is a potential target antigen for autoantibodies in some infectious and autoimmune diseases.
          
    We measured the level of anti-vimentin antibodies in patients with systemic autoimmune diseases (n=42), healthy blood donors (n=58), and patients with acute inflammation and showing anti-vimentin immunofluorescence (n=50).
          
    There were no differences between the levels of anti-vimentin antibodies between patients with systemic autoimmune diseases and healthy individuals.
          
    At the same time it is becoming apparent that some remedies usually used to treat somatic and psychic disorders also have immunomodulating properties, and may help manage multiple sclerosis and other autoimmune diseases.
          
    Objective: Heat shock proteins (hsps) have been shown to be important antigens in a number of autoimmune diseases.
          
    更多          
      auto immune diseases
    MacKay and Burnet3 categorize the auto immune diseases in several main groups.
          
    These include certain viral infections, auto immune diseases and pregnancy.
          
      auto immune disease
    Electrochmemiluminescence has been applied today to a wide range of analytes of biological interest including thyroid and fertility hormones, infectious desease, as well as various markers of cardiac, malignant and auto immune disease.
          
    Trans fats are associated with auto immune disease, skin problems, growth problems in children and learning disabilities.
          
    There are difficulties with the idea of MS being primarily an auto immune disease.
          
    The presence of antibodies directed against the nucleus of the cell is a hallmark of auto immune disease.
          


    Immunohistopathologic staining technique using monoclonal antibody against PGL-1 antigen and anti-S100 protein antibody were applied along with the routine histopathologic HE and AF staining techniques on 9 confirmed patients with paucibacillary(PB) and 1 confirmed multibacillary(MB) leprosy as well as on 1 suspected case of PB and 11 MB clinically suspected relapsed cases of leprosy.In the 9 confirmed PB patients,3 were AF,7 PGL-1 and 6 S100 protein staining positive;but in the suspected PB relapsed case,though...

    Immunohistopathologic staining technique using monoclonal antibody against PGL-1 antigen and anti-S100 protein antibody were applied along with the routine histopathologic HE and AF staining techniques on 9 confirmed patients with paucibacillary(PB) and 1 confirmed multibacillary(MB) leprosy as well as on 1 suspected case of PB and 11 MB clinically suspected relapsed cases of leprosy.In the 9 confirmed PB patients,3 were AF,7 PGL-1 and 6 S100 protein staining positive;but in the suspected PB relapsed case,though AF and PGL-I staining were negative,but S100 protein staining was positive in the infiltrated areas of the biopsy. In the confirmed MB cases all the specific criteria were positive.whereas in the 11 suspected MB relapsed cases only 8 showed AF and PGL-1 staning positive.6 showed S100 protein staining positive.In the 3 AF and PGL-1 staining negative cases,relapse can not be confirmed.Thus PGL-1 and S100 protein staining are of assistance in the diagnosis of early leprosy and in the verification of relapse from reversal reaction in problem cases.

    SLE患者皮质类固醇治疗前后血清IL-2和TNF-α水平的比较刘国英①瞿国伟②SLE是一种以免疫调节异常为特征的自身免疫性疾病,而免疫调节主要是通过多种细胞因子相互作用实现的。因此,研究SLE病人细胞因子变化将有助于阐明该病的发病机理,我们检测了14...

    In order to detect the antibodies to melanocytes in vitiligo patients' sera and the sera induced damage to human melanocytes in vitro by complement mediated cytotoxicity Immunocytochemistry was used to detect antimelanocyte IgG,IgM antibodes and melanocyte cytotoxicity was measured using an acridine orange/ethidium bromide cellular viability assay The results showed that of 25 patients with active vitiligo, IgG antibodies were present in 19(76%) and in a homogeneous pattern; IgM antibodies in 21(84%) patients...

    In order to detect the antibodies to melanocytes in vitiligo patients' sera and the sera induced damage to human melanocytes in vitro by complement mediated cytotoxicity Immunocytochemistry was used to detect antimelanocyte IgG,IgM antibodes and melanocyte cytotoxicity was measured using an acridine orange/ethidium bromide cellular viability assay The results showed that of 25 patients with active vitiligo, IgG antibodies were present in 19(76%) and in a homogeneous pattern; IgM antibodies in 21(84%) patients and in a cytoplasmic pattern Singnificant melanocyte cytotoxicity was seen with vitiligo patient sera as an antibody source Seventeen of 25 vitiligo patient sera produced cytotoxicity by complement mediated lysis No cytotoxicity was seen using fibroblast control and normal sera The results of this study indicate that antimelanocyte autoantibodies presented in the sera of patients with vitiligo have functional ability to selectively kill melanocytes and more common in active disease, which supports the hypothesis that vitiligo is an automimmune disease

    为探讨白癜风血清中的抗黑素细胞抗体类型和反应模式以及对黑素细胞的损伤作用 ,以免疫组化法检测了白癜风患者血清中抗黑素细胞IgG、IgM抗体 ,并以吖啶橙 /溴化乙锭细胞染色法观察补体介导的白癜风血清对黑素细胞损伤作用。结果发现 2 5例活动性寻常型白癜风患者血清中有 19例检出IgG型抗体 ,2 1例检出IgM型抗体 ,明显高于稳定期和正常对照组血清 ;2 5例活动期血清 9例出现对黑素细胞的明显细胞毒作用 ,高于正常人血清 ,对照的成纤维细胞未出现明显的细胞毒作用。结果提示白癜风患者血清内有抗黑素细胞IgG、IgM抗体 ,这些抗体可以通过补体选择性的损伤体外培养的黑素细胞 ,支持白癜风是一种自身免疫性疾病的假设。

    Objective To study the effect of Interferon-γ(IFN-γ) on preventing relapse of condyloma acuminatum (CA). Method Seventy-six patients were diagnosed as CA. The patients having connective tissue disease, allergic disease, serious systematic disease, other virus disease, immuno-modulatory drug or immuno-suppressive drug to be used in one year were excluded. The rash of all patients were eliminated with electrofulguration. The patients were divided into two groups: IFN-γ and control. Thirty-eight cases of...

    Objective To study the effect of Interferon-γ(IFN-γ) on preventing relapse of condyloma acuminatum (CA). Method Seventy-six patients were diagnosed as CA. The patients having connective tissue disease, allergic disease, serious systematic disease, other virus disease, immuno-modulatory drug or immuno-suppressive drug to be used in one year were excluded. The rash of all patients were eliminated with electrofulguration. The patients were divided into two groups: IFN-γ and control. Thirty-eight cases of patients with CA were treated with IFN-γ and were compared with 38 patients treated with PolyI:C. The T-cell subpopulation (CD 3、CD 4、CD 8) in peripheral blood of patients treated with IFN-γ were determined by APAAP before electrofulguration and after therapy. All the patients were followed-up for 6 months. Results The results showed that the relapse rate was 15 8% in IFN-γ group, while it was 36 8% in the control in 6 months after therapy. In 32 patients, who had no relapse in 6 months after therapy, the T-cell recovered to normal. While there was no significant change in 6 patients with relapse in 6 months after therapy. Conclusion It indicates that the relapse rate of the therapy group is significantly lower than the control (χ 2=4 34,P<0 05). IFN-γ is a cell factor effective to prevent and cure CA.

    【目的】研究干扰素 γ(IFN γ)对预防尖锐湿疣 (CA)复发的效果。【方法】收集了 76例确诊为CA的患者 ,排除伴有自身免疫性疾病和其他过敏性疾病、严重的系统性疾病、其他病毒感染性疾病、1年内用过免疫增强剂或免疫抑制剂的患者。全部病例电灼除疣 ,电灼后随机分两组 :治疗组 38例 ,继以IFN γ肌注治疗 ;对照组 38例 ,采用聚肌胞肌注治疗 ;两组随访 6个月。治疗组在电灼前及治疗后均用APAAP法检测患者的T淋巴细胞亚群 (CD3、CD4 、CD8)。【结果】治疗组的复发率为 15 8% ,对照组的复发率为 36 8% ;治疗组 6个月内未复发的 32例患者 ,T细胞恢复正常。复发的 6例 ,治疗前后T细胞亚群无明显变化。【结论】治疗组的复发率低于对照组 (χ2 =4 34,P <0 0 5 )。IFN γ是防治CA的一种有效的细胞因子。

     
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