Cyclophosphamide (CPA), a common antineoplastic agent, is often used with dexamethasone (DEX) for the combined chemotherapy of various tumors, the imunosuppressive blockage of allograft rejection and treatment of autoimmune disease.
Rheumatoid arthritis (RA) is currently considered an autoimmune disease in which a pathological immune response attacks synovial cells, cartilage, and bone resulting in joint destruction and permanent disability.
Background Both clinical and experimental observations suggest that a number of autoimmune diseases occur more frequently in females than in males, such as a female-to-male incidence ratio of rheumatoid arthritis, systemic lupus erythematosus and autoimmune thyroiditis was 1:3, 1:9, 1:19 respectively.
An agent inhibiting lck would block T cell function effectively. Act as an immunosuppressive agent, it has potential utility in autoimmune diseases, the transplant rejection, allergic diseases as well as cancers.
And it has been reported that the elevated plasma estrogen level during pregnancy can change the body immune conditions significantly, among which the shift of Th1 cell response to Th2 cell response suppresses Th1 cell-mediated autoimmune diseases such as MS, RA and EAE while worsens Th2 cell-mediated ones such as AITD and MG.
The development of lupus-like autoimmune disease of MRL/MpJ-lpr mice is an experimental model for study of autoimmune pathologies and immunopathogenesis.
Multiple sclerosis is a chronic inflammatory, putatively autoimmune disease characterized by multifocal demyelination in the central nervous system.
Systemic lupus erythematosus (SLE) is an autoimmune disease which occurs in over 80% in women during childbearing years.
The association with thymoma and raised AChR antibody suggests that this syndrome represents a unique type of autoimmune disease, in which antibodies against the AChR facilitate rather than inhibit cholinergic action.
The occurrence of a chronic inflammatory reaction in one of the two patients supports the idea that an autoimmune disease against GABA-ergic neurons may be involved in SMS.
Electrochmemiluminescence has been applied today to a wide range of analytes of biological interest including thyroid and fertility hormones, infectious desease, as well as various markers of cardiac, malignant and auto immune disease.
Trans fats are associated with auto immune disease, skin problems, growth problems in children and learning disabilities.
There are difficulties with the idea of MS being primarily an auto immune disease.
The presence of antibodies directed against the nucleus of the cell is a hallmark of auto immune disease.
The intermediate filament protein vimentin is a potential target antigen for autoantibodies in some infectious and autoimmune diseases.
We measured the level of anti-vimentin antibodies in patients with systemic autoimmune diseases (n=42), healthy blood donors (n=58), and patients with acute inflammation and showing anti-vimentin immunofluorescence (n=50).
There were no differences between the levels of anti-vimentin antibodies between patients with systemic autoimmune diseases and healthy individuals.
At the same time it is becoming apparent that some remedies usually used to treat somatic and psychic disorders also have immunomodulating properties, and may help manage multiple sclerosis and other autoimmune diseases.
Objective: Heat shock proteins (hsps) have been shown to be important antigens in a number of autoimmune diseases.