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混合T
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Monoclonal antibody marker studies performed on 10 cases of NHL showed that all tumor cells were positive for Leu 1. Leu3. Leu4 and negative for Leu2, OKT6, B1, K, A. The percentage of E-rosettes among medium and large cells range from 45 to 67%. 5 cases showed not possitivity for ANAE. Studied urider the light microscope 6 types or, cells could be identified: 1, Cells with twisted "swingly" nuclei and abundant pale cytoplasm. 2. Cells with round pale staining nuclei and abundant clear cytoplasm. 3. "large non-cleave...

Monoclonal antibody marker studies performed on 10 cases of NHL showed that all tumor cells were positive for Leu 1. Leu3. Leu4 and negative for Leu2, OKT6, B1, K, A. The percentage of E-rosettes among medium and large cells range from 45 to 67%. 5 cases showed not possitivity for ANAE. Studied urider the light microscope 6 types or, cells could be identified: 1, Cells with twisted "swingly" nuclei and abundant pale cytoplasm. 2. Cells with round pale staining nuclei and abundant clear cytoplasm. 3. "large non-cleave like" T cells. 4. Cells with medium round or slightly irregular nuclei and scanty cytoplasm. 5 . Immu-noblast. 6. Bizarre cells. Transitional forms were seen between these 6 types, suggesting a sequence of transformation from small to large. 5 consisted of a mixture of small and medium swingly cells with "LNC" like T Cells, 2 mainly of immunoblasts, 2 of medium clear rpund cells nuclear, 1 of irregular medium cells.The pattern of growth could be grouped into 4 categories: 1. Para cortical. 2 . Architecture indistinct witn "nodular" like appearance. 3. Node architecture effaced out EV prominent. 4 . Complete loss of nodai architecture. Taking into consideration the various types of TL sub-groups that have been defined in the literature, and the histological appearance seen in our 10 cases, we suggest ths addition of the following types. 1 , Clear rourd nuclear type, 2. Clear irregular nuclear type, (polymorphic), 3. Mixture of transformed T lymphocytes consisting of both large and small cells.

本文分析10例经单克隆抗体标记证实为外周T细胞淋巴瘤的病理形态,每例均用ABC法作Leu_1、Leu_2、Leu_3、Leu_4、OKT_3、oKT_6,HLA-DR(Ⅰ_s)、B_1、Kappa(k)、Lainbda(λ)免疫标记测定,证实为辅助T细胞来源,E花结测定见大中淋巴样细胞中有45~65%形成花结,5例ANAE点状阳性,2例ACP阳性。光镜下Peri TL的细胞形态可归结为六类。作者根据其相互之间的过渡形态推测了外周T淋巴细胞的转化过程,并结合肿瘤细胞的生长方式建议Peri TL再增加以下四个亚型:(1)透明圆核细胞性,(2)多形细胞性,即透明扭核细胞性,(3)混合T细胞性,(4)单纯圆细胞性。

To induce efficient and specific anti tumor immune response in vivo with dendritic cells(DCs),DCs from isolated and proliferated peripheral blood of colocarcinoma were stimulated with extracts from human colorcarcinoma cell line LOVO, activated with combination of granulocyte/macrophage colony stiumlating factor(GM CSF) and interleukin 4(IL 4). DCs were used to proliferate and differentiate T lymphocyte to cytotoxical T lymphocyte (CTL), and to kill LOVO tumor cells by CTL and its supernate. The result showed...

To induce efficient and specific anti tumor immune response in vivo with dendritic cells(DCs),DCs from isolated and proliferated peripheral blood of colocarcinoma were stimulated with extracts from human colorcarcinoma cell line LOVO, activated with combination of granulocyte/macrophage colony stiumlating factor(GM CSF) and interleukin 4(IL 4). DCs were used to proliferate and differentiate T lymphocyte to cytotoxical T lymphocyte (CTL), and to kill LOVO tumor cells by CTL and its supernate. The result showed that CTL and its supernate induced by the DCs could selectively kill HepG2 tumor cells (killing rate 91%±12% and 69%±9% respectively). We think that DCs from tumor patients will play an important role in the therapy and prevention of tumor.

为达到以结肠癌患者外周血树突状细胞(DC)在体外诱导抗结肠癌免疫反应的目的,以结肠癌细胞系LOVO肿瘤细胞的肿瘤抗原粗提物激活并经GM-CSF及IL-4联合刺激的结肠癌患者外周血树突状细胞(DC)体外能够诱导自体混合T淋巴细胞增殖、分化为CTL,该CTL及其上清液对LOVO肿瘤细胞均有强大的杀伤力,而对HepG2肿瘤,该CTL细胞及HOS-8603肿瘤细胞仅有微弱的细胞毒作用。结果表明结肠癌患者外周血DC体外能够诱导高效而特异抗结肠癌免疫反应。提示DC作为一新概念上的肿瘤疫苗可能在肿瘤治疗及预防中发挥重要作用

Aims: In this study we developed another cancer vaccine based on deactivated tumor cells and lysate pulsed bone marrow generated dendritic cells (DC)and investigated whether the vaccine was capable of inducing antitumor immune responses in vivo.Methods: Using the isolation and expansion procedure established previously in our laboratory a large number of DCs were obtained,and pulsed in vitro with inactivated NS 1 myeloma cells and lysates,and then used as a cancer vaccine in the animal experiments.Results:...

Aims: In this study we developed another cancer vaccine based on deactivated tumor cells and lysate pulsed bone marrow generated dendritic cells (DC)and investigated whether the vaccine was capable of inducing antitumor immune responses in vivo.Methods: Using the isolation and expansion procedure established previously in our laboratory a large number of DCs were obtained,and pulsed in vitro with inactivated NS 1 myeloma cells and lysates,and then used as a cancer vaccine in the animal experiments.Results: Cultured DCs were potent stimulators in allogeneic mixed T lymphocyte reactions.After the pulsed DC vaccination of normal mice,these immunized animals were induced to develop more potent cytotoxic T lymphocytes (CTL) activity against stimulators targeted tumor cells,and obtained more effective immunoprotection from subsequent challenges of wild live NS 1 myeloma cells than those after vaccination directly with deactivated tumor cells.After active immunotherapy for the tumor bearing mice with the pulsed DC vaccine,the rate of their survival was increased and the survival time was greatly extended,and model tumor volumes were reduced or regressed.Conclusions:These results suggest that vaccination of normal and tumor bearing mice with the tumor lysate pulsed DCs could prime more potent antitumor immune response.It is concluded that the tumor antigen pulsed DC vaccine can enhance tumor immunogenicity and mediate tumor regession,indicating that it likely becomes a useful preparation for immunoprevention and immunotherapy of tumors.

目的:进一步研究体外肿瘤抗原脉冲致敏的骨髓树突状细胞瘤苗主动免疫诱导小鼠体内抗肿瘤免疫应答,并观察其抵抗野生性肿瘤攻击的免疫保护作用及对荷瘤小鼠模型的免疫应答。方法:采用本室建立的骨髓树突状细胞分离与细胞因子体外扩增培养方法,并在体外经灭活NS1骨髓瘤细胞及其裂解产物脉冲刺激后直接作为疫苗,然后进行免疫预防与治疗的在体动物实验。结果:可从1只小鼠股骨中获得(3~5)×105个树突状细胞(DC),其纯度为95%以上,对混合T淋巴细胞具有强刺激活性。主动免疫同系健康BALB/C小鼠的试验显示,DC疫苗能诱导抗原特异的细胞毒性T淋巴细胞(CTL)活性,免疫1次的动物首次受到肿瘤攻击后诱发肿瘤形成率为0%,再次攻击的肿瘤形成率为20%;而免疫3次的动物两次攻击的肿瘤形成率皆为0%。主动免疫治疗同种荷瘤动物的试验表明,DC疫苗也能抑制肿瘤生长,荷瘤动物存活率提高及生存期明显延长。结论:肿瘤抗原体外致敏的树突状细胞能诱导宿主体内的抗肿瘤免疫保护性反应,且对荷瘤模型动物具有明显的免疫治疗作用。

 
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