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职业性膀胱癌
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  “职业性膀胱癌”译为未确定词的双语例句
     Mortality and Incidence of Bladder Cancer in Benzidine Exposed Workers in China
     中国联苯胺作业工人职业性膀胱癌发病率和死亡率流行病学调查
短句来源
     [Conclusion] The detection of gene AN43 and the quantitative PCR of expressed product mRNA could act as the monitoring index for controling precancerous condition in high risk population of occupational bladder cancer and one of the early dignosis index for bladder cancer.
     [结论] AN43基因检测及其m RNA 的定量PCR法不仅可作为职业性膀胱癌高危人群癌前病变控制的监护指标,也可作为膀胱癌早期诊断指标之一
短句来源
     For the high risk workers,the time elapsed for the occurrence of clinical cancer was 18 months in average and the average patent time of occupational bladder cancer was 21.2 years (5~30 years).
     高危险度者发展到临床确诊平均历时 18个月。 职业性膀胱癌发病潜伏期 5~ 30年 ,平均 2 1.2年。
短句来源
     Conclusions Pap cytology and QFIA are beneficial to the early diagnosis and screening of occupational bladder cancer.
     结论 巴氏细胞学检查和QFIA法有利于发现潜在发生职业性膀胱癌的高危人群、早期诊断职业性膀胱癌
短句来源
     The biological monitoring and its significance in the diagnosis of occupational bladder cancer
     中国职业性膀胱癌的生物学监测及其意义
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  相似匹配句对
     The biological monitoring and its significance in the diagnosis of occupational bladder cancer
     中国职业性膀胱癌的生物学监测及其意义
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     Chemoprevention of bladder cancer
     膀胱癌的化学预防
短句来源
     PROFESSIONAL ASTHMA
     职业性哮喘
短句来源
     Objective To make early diagnosis of occupational bladder cancer in benzine-exposured worker in China.
     目的 早期诊断中国联苯胺作业工人职业性膀胱癌
短句来源
     Current Therapy of Bladder Cancer
     膀胱癌的现行疗法
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To probe the potential hazards of the dyes, the work has done as follow: essential improvements of Ames test was made, thus the sensitivity of the test was much increased and12 different benzidine--derived dyes were proved to be mutagenic' Except for lactic bacillus allthe bacterium species of the intestinal tract were found to be able to reduce azo--dyes to release benzidine. The test with resected intestinal sedments of the rats revealed that the cecum is the most active site of dye-reduction, with the colon...

To probe the potential hazards of the dyes, the work has done as follow: essential improvements of Ames test was made, thus the sensitivity of the test was much increased and12 different benzidine--derived dyes were proved to be mutagenic' Except for lactic bacillus allthe bacterium species of the intestinal tract were found to be able to reduce azo--dyes to release benzidine. The test with resected intestinal sedments of the rats revealed that the cecum is the most active site of dye-reduction, with the colon as the second active site, whilethe small intestine is practically devoid of dye-reduction. The culture of intestinal contentwith and without previous additional antibiotics revealed that the former had great inhibitiono f bacteria growth increase in the rate of inhibition of bacteria reduction.Gastric intubation of dyes with and without simultaneous application of antibiotics, theformer had much decreased production of benzidine,showed that the increase in rate of inhibition of bacteria reduction, the former group also showed reduced mutagenicity of the urine.Bacteria culture of human-feces had mutagenic activity which much reduced after applicationof antibiotics.In an in vivo test of inhibition of gut flora, the proliferation of oval cells in liver of F344rats was obviously decreased, the toxicity and the incidence of acute lymphoid leukemia weredecreased. This suggested that the carcinogenicity of benzidine--derived dye was also correspondingly reduced.

经流调发现,职业性膀胱癌仅在接触联苯胺单体的人员中高发,接触染料者则很少发生。为探讨该类染料的潜在危害,作了以下各项研究。证实除乳酸杆菌外,常见的肠道苗都具有使偶氮染料还原退色、释放联苯胺的作用。对Ames试验作了较大的改进,提高了灵敏度。证实实验用的12种联苯胺衍生染料都具有致变性。离休肠段孵育试验,证实还原退色作用主要在闹肠。大肠内容物经培养增菌后,再置入抗生素,则还原抑制率增长。大鼠灌食染料,加用抗生素则肠内容物中的联苯胺含量有所降低,其尿致变活性也有所降低,人粪培养液中加入联苯胺染料后,培养显示有致变性,施用肠道菌抑制剂后,显示致变活性降低;大鼠整体染毒试验显示肝卵园细胞增生、SD大鼠肝毒性、淋巴细胞样白血病发病均明显降低,提示抑制肠道菌使联苯胺衍生染料的致癌活性降低。

Objective]To explore a special and reliable method for the monitoring of high risk population of occupational bladder cancer and the clinical diagnosis of bladder cancer.[Method] Using nuclic acid probe hybridization technique,immunohistochemistry and quantitative PCR detected gene AN43.Using quantitative PCR detected expressed product——mRNA in peripheral white blood cells in 50 cases of high risk to bladder cancer,18 cases of bladder carcer and 30 cases of healthy people compared its result with the urine cell...

Objective]To explore a special and reliable method for the monitoring of high risk population of occupational bladder cancer and the clinical diagnosis of bladder cancer.[Method] Using nuclic acid probe hybridization technique,immunohistochemistry and quantitative PCR detected gene AN43.Using quantitative PCR detected expressed product——mRNA in peripheral white blood cells in 50 cases of high risk to bladder cancer,18 cases of bladder carcer and 30 cases of healthy people compared its result with the urine cell pathological examination result.[Results] The detection rate of gene AN43 in high risk population of occupational bladder cancer and the readings on the quantitative PCR of expressed product mRNA were higher significantly than these in the control,and lower than these in the bladder cancer group.[Conclusion] The detection of gene AN43 and the quantitative PCR of expressed product mRNA could act as the monitoring index for controling precancerous condition in high risk population of occupational bladder cancer and one of the early dignosis index for bladder cancer.

[目的]为职业性膀胱癌高危人群的监护及膀胱癌的临床诊断探索一种特异、可靠的手段。[方法]应用核酸探针杂交技术,免疫组化法及定量PCR方法对50 例膀胱癌高危人群,18 例膀胱癌患者及30 例健康人群进行外周血白细胞中AN43 基因及其m RNA 的定量PCR检测,并与尿细胞病理学检查结果进行比较。[结果] 职业性膀胱癌高危人群AN43 基因的检出率及其m RNA的定量PCR读数均明显高于对照人群而低于膀胱癌患者。[结论] AN43基因检测及其m RNA 的定量PCR法不仅可作为职业性膀胱癌高危人群癌前病变控制的监护指标,也可作为膀胱癌早期诊断指标之一

This study was aimed to ascertain the distribution of glutathione S transferase(GSTs)M1 and T1 gene polymorphism related to the risk of bladder cancer development in high risk population occupationally exposed to benzidine.It was conducted by comparing every genotype proportion between the population occupationally exposed to benzidine in Shanghai dyestuff industry and a control one in Shanghai manufacture industry.Another analysis was to make the stratified analyses on the job and the exposure special time...

This study was aimed to ascertain the distribution of glutathione S transferase(GSTs)M1 and T1 gene polymorphism related to the risk of bladder cancer development in high risk population occupationally exposed to benzidine.It was conducted by comparing every genotype proportion between the population occupationally exposed to benzidine in Shanghai dyestuff industry and a control one in Shanghai manufacture industry.Another analysis was to make the stratified analyses on the job and the exposure special time in the exposed population.The results showed that the proportions of genotype of T1 0/0,M1 0/0 and T1 0/0-M1 0/0 in the exposed population were higher than that in the control population,and the statistically significant difference was shown in the genotype of T1 0/0-M1 0/0(OR=1 58,χ 2=5 41).No significant trend or difference was displayed in the stratified analyses of occupational factors.It was observed that the population frequency of GSTs 0/0 genotype was shifted to a higher level in the occupational population with bladder cancer high risk.Since all the subject tested in this study have not been diagnosed as bladder cancer patient yet,though the exfoliation samples from part of cohort members were cytologically proved at different premalignant stages,this special occupational population should be regarded,basically,as a healthy one.The fact that the strength and extent of benzidine exposure showed no notable affect towards frequency shifting of GSTs 0/0 genotype in the population seems to be in consistency with “no threshold”theory of chemical carcinogenesis.

为了探讨与膀胱癌发生危险有关的谷胱甘肽S -转移酶 (GSTs)M 1和T1基因型的多态性在有联苯胺接触的膀胱癌高危人群中的分布状况 ,对上海市染料化工行业的联苯胺接触人群与上海市某制造行业的健康对照人群作各种基因型构成比的比较 ,在接触人群中进行工种和工龄的职业因素分层分析。结果表明 ,接触人群中T10 / 0型、M 10 / 0型、和T10 / 0 -M10 / 0型的构成比均高于对照人群 ,在T10 / 0 -M10 / 0型的构成比上出现统计学意义 (OR =1 5 8,χ2 =5 41)。职业因素分层分析未发现显著的趋势或差异。结果中 ,职业性膀胱癌高危人群中GSTs 0 / 0基因型的构成比向高比例方向移动可以理解。但研究中该人群虽是一个特殊职业人群 ,可从根本上说仍应属于健康人群 ,而健康人群中GSTs 0 / 0基因型的构成比会产生漂移 ,在过去的研究中尚未见过。联苯胺的接触强度和接触程度未影响整个接触人群GSTs 0 / 0基因型的构成比漂移的基本情况 ,可佐证化学致癌过程无阈值的理论

 
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