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   移行细胞癌 在 基础医学 分类中 的翻译结果: 查询用时:0.019秒
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移行细胞癌
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  transitional cell carcinoma
Nephroureterectomy with removal of a bladder cuff was performed successfully on a 47-year-old man for transitional cell carcinoma of the right renal pelvis using hand-assisted laparoscopy.
      
Alteration of G1-cyclins (D1 and E) in transitional cell carcinoma of human urinary bladder with infection of HPV-18
      
Objective: This study was designed to investigate differential pattern of G1-cyclins (D1 and E) in transitional cell carcinoma (TCC) of human urinary bladder with or without human papillomavirus-18 (HPV-18) infection.
      
Recurrence risk factors in patients with transitional cell carcinoma of bladder
      
Methods: An analysis on recurrence-related factors was made by Cox's proportional hazards model analysis and logistic multiple linear regression model analysis in 212 patients with transitional cell carcinoma treated surgically from 1995~2001.
      
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Two 23-mer unmodified oligodeoxynucleotideshave been synthesized, one to hybridize withthe region across the transcription initiationsite of TGFa cDNA called antisense, and thesecond with an identical base composition, butthe nucleotide sequence randomized. The ran-dom oligodeoxynucleotide was used to controlfor any non-specific effects of theoligodeoxynucleotides. TGFα antisense inhib-ited cell proliferation and DNA synthesis from31 /00 to 44/00 and 25. 8/00 to 88. 0% respective-ly. This effect is specific...

Two 23-mer unmodified oligodeoxynucleotideshave been synthesized, one to hybridize withthe region across the transcription initiationsite of TGFa cDNA called antisense, and thesecond with an identical base composition, butthe nucleotide sequence randomized. The ran-dom oligodeoxynucleotide was used to controlfor any non-specific effects of theoligodeoxynucleotides. TGFα antisense inhib-ited cell proliferation and DNA synthesis from31 /00 to 44/00 and 25. 8/00 to 88. 0% respective-ly. This effect is specific and dose-responded.However. at the same condition, the inhibi-tion by random is only 10% to 17% and 17%to 27%. This effect is not dose-responded. ByRNA dot blot analysis , the addition of 3 μmol / LTGFα antisense and random upon BIU87 cellsresulted in 61. 4% and 42. 5% inhibition inTGFα mRNA expression respectively. Theseresults suggested that TGFα may play an im-portant role in the proliferation of BIU87 cellline and provide a rational basis for the devel-opment of selective cancer therapeutical ap-oroaches .

报道了23碱基组成的TGFα反义寡聚核苷酸和对照寡聚核苷酸对人膀胱移行细胞癌BIU87细胞增殖及其TGFαmRNA表达的作用,结果表明:TGFα反义寡聚核苷酸抑制体外培养的BIU87细胞的增殖、DNA合成和TGFαmRNA的表达,进一步证明了TGFα在BIU87细胞恶性增殖中的重要作用.

β Glucuronidase(β G) is low in normal human tissue fragment and body liquid. In this experiment, colloid gold labelling and immunoelectron microscope technique were used for the localization of β G in normal human body transitional cell and transitional cell carcinoma respectively. The result showed that β G was localized in endoplasmic reticulum and lysosome in normal and malignant transitional cells. At the same time, we found that the number of gold granules was greater in carcinoma cells than in normal...

β Glucuronidase(β G) is low in normal human tissue fragment and body liquid. In this experiment, colloid gold labelling and immunoelectron microscope technique were used for the localization of β G in normal human body transitional cell and transitional cell carcinoma respectively. The result showed that β G was localized in endoplasmic reticulum and lysosome in normal and malignant transitional cells. At the same time, we found that the number of gold granules was greater in carcinoma cells than in normal transitional ones. The result of the experiment may offer a new method for early discovering and early diagnosing of transitional cell carcinoma.

β-葡萄糖醛酸酶(β-Glucuronidase,简称β-G)在正常人体组织匀浆和体液中含量很低,本实验采用胶体金标记,免疫电镜技术,进行了人体正常移行细胞与移行细胞癌细胞内β-G定位研究,实验结果表明,β-G存在于移行细胞和移行细胞癌细胞中的内质网、溶酶体内,同时观察到癌细胞中标记β-G的金颗粒数量多于正常移行细胞中金颗粒的数量,本实验结果可能对于移行细胞癌的早期发现、早期诊断提供了新的依据。

Objective To determine the expression of apoptosis and PCNA in superficial transitional cell bladder cancer and to evaluate its significance as a recurrence marker. Method 87 cases of superficial transitional cell bladder cancer were analysed for the expression of apoptosis and PCNA by using the 3end labeling method of DNA and immunohistochemical staining in tissue sections. The apoptotic indexes and PCNA indexes were respectively the percentages of apoptotic cells or PCNA positive cells among...

Objective To determine the expression of apoptosis and PCNA in superficial transitional cell bladder cancer and to evaluate its significance as a recurrence marker. Method 87 cases of superficial transitional cell bladder cancer were analysed for the expression of apoptosis and PCNA by using the 3end labeling method of DNA and immunohistochemical staining in tissue sections. The apoptotic indexes and PCNA indexes were respectively the percentages of apoptotic cells or PCNA positive cells among tumor cells. Result The end labeling method allowed a precise evaluation of the expression of apoptosis. Apoptosis occurred in 896% of superficial transitional cell bladder cancer. In 17 patients who suffered from tumor recurrence,the ratio of apoptosis indexes to PCNA indexes was significantly higher than that in those without recurrence (P<001). Conclusion The ratio of apoptosis indexes to PCNA indexes was believed to be related to tumor recurrence and might be of value in the assessment of recurrence of superficial transitional cell bladder cancer.

目的研究表浅膀胱移行细胞癌中细胞凋亡及增殖细胞核抗原(PCNA)表达情况,并初步探讨其与表浅膀胱移行细胞癌复发的关系。方法采用原位DNA末端标记法及免疫组织化学方法检测了87例表浅膀胱移行细胞癌中细胞凋亡及PCNA表达情况,计算出细胞凋亡指数及PCNA表达指数,并对复发组与非复发组进行比较。结果复发组与非复发组细胞凋亡指数差异无显著意义,而凋亡指数与PCNA指数比值在复发组小于非复发组(P<001),显示在复发组癌细胞的增殖程度明显高于细胞凋亡程度。结论对凋亡指数及PCNA阳性指数的综合分析,即凋亡指数与PCNA阳性指数的比值,可更全面的反映细胞凋亡与增殖的平衡状态,对判断肿瘤的复发具有参考价值。

 
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