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   移行细胞癌 在 心血管系统疾病 分类中 的翻译结果: 查询用时:0.018秒
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移行细胞癌
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  transitional cell carcinoma
Nephroureterectomy with removal of a bladder cuff was performed successfully on a 47-year-old man for transitional cell carcinoma of the right renal pelvis using hand-assisted laparoscopy.
      
Alteration of G1-cyclins (D1 and E) in transitional cell carcinoma of human urinary bladder with infection of HPV-18
      
Objective: This study was designed to investigate differential pattern of G1-cyclins (D1 and E) in transitional cell carcinoma (TCC) of human urinary bladder with or without human papillomavirus-18 (HPV-18) infection.
      
Recurrence risk factors in patients with transitional cell carcinoma of bladder
      
Methods: An analysis on recurrence-related factors was made by Cox's proportional hazards model analysis and logistic multiple linear regression model analysis in 212 patients with transitional cell carcinoma treated surgically from 1995~2001.
      
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Objective:To evaluate the short-term effects of bladder cancer by transcatheter intra-arterial chemotherapy with high-dose CDDP and ADM.Methods:76 patients with pathologically confirmed bladder cancer were treated with high-dose CDDP and ADM by transcatheter intra-arterial chemotherapy.The doses were:CDDP:100mg/m 2 ADM:30 mg/m 2.With 2 cycles by an interval of 3~4 weeks,pathological changes before and after the therapy under optical microscope and electron microscope were compared.The short-term effects and...

Objective:To evaluate the short-term effects of bladder cancer by transcatheter intra-arterial chemotherapy with high-dose CDDP and ADM.Methods:76 patients with pathologically confirmed bladder cancer were treated with high-dose CDDP and ADM by transcatheter intra-arterial chemotherapy.The doses were:CDDP:100mg/m 2 ADM:30 mg/m 2.With 2 cycles by an interval of 3~4 weeks,pathological changes before and after the therapy under optical microscope and electron microscope were compared.The short-term effects and side effects of this method were analyzed.Result:Complete response in 11(14.47%)and a partial response in 45(59.21%)of the patients were achieved after the therapy.20(26.32%)had no response.The total anticancer effective rate was 73.68%.Pathological findings of 42 patients indicated downstaging in 8(19.05%)patients,no tumor cell found in 6(14.29%)patients.Distinct changes were observed under electron microscope.Side effects were tolerable.Conclusion:intra-arterial chemotherapy for bladder cancer with high dose of CDDP and ADM is effective.Bilateral hypogastric angiography should be taken to calculate the ratio of drugs for both sides.To those who have a decreased renal function,this method should not be recommended.

目的:总结大剂量顺铂+阿霉素方案经髂内动脉灌注治疗膀胱癌的近期疗效。方法:对76例经病理证实且肾功能正常的膀胱癌患者行大剂量顺铂+阿霉素髂内动脉灌注化疗。药物剂量:顺铂:100mg/m2,阿霉素:30mg/m2。化疗进行两次后,对比观察治疗前后肿瘤病理及超微结构的变化,并对该方案的近期疗效及副作用进行评价。结果:经两个疗程治疗,76名患者中,安全缓解(CR)11例(14.47%),部分缓解(PR)45例(59.21%),无效者20例(26.32%),总反应率73.68%。化疗后,有病理学资料的42例患者中,8例(19.05%)移行细胞癌肿瘤分级有所降低,6例(14.29%)病理学检查肿瘤细胞消失。肿瘤细胞超微结构的改变明显。结论:大剂量顺铂+阿霉素方案对于膀胱癌疗效明显,值得推广,但肾功能异常者应慎用该方案。为了提高疗效,减少副作用,动脉灌注时应行双侧髂内动脉造影,合理分配化疗药物。

Objective To elucidate rasP21 and P53 expression in bladder transitional carcinoma and their relationship with pathological grade,clinical stage,recurrence,tumor size and patients′ ages.Methods rasP21 and P53 expression at protein level were studied in 47 cases of bladder transitional carcinoma with flow cytometric(FCM)and pathological methods.Results With the differentiation of the bladder cancer,rasP21 and P53 positive expressions were significantly increased.There were statistical significance on grade...

Objective To elucidate rasP21 and P53 expression in bladder transitional carcinoma and their relationship with pathological grade,clinical stage,recurrence,tumor size and patients′ ages.Methods rasP21 and P53 expression at protein level were studied in 47 cases of bladder transitional carcinoma with flow cytometric(FCM)and pathological methods.Results With the differentiation of the bladder cancer,rasP21 and P53 positive expressions were significantly increased.There were statistical significance on grade Ⅰand Ⅱ as compared with grade Ⅲ ( P < 0.05 ),rasP21 and P53 positive expressions were higher in stage T2 to T4 as compared with T1( P < 0.05 ).Recurrence rate of rasP21 and P53 positive cases was 51.6% (16/31)and 45.7% (16/35),respectively,while recurrence rate of rasP21 and P53 negative cases was 12.5% (2/16) and 16.6% (2/12),respectively.rasP21 and P53 positive expression had no statistical significance with tumor size and patients′ ages.Conclusion rasP21 and P53 expression may be a valuable marker in evaluation of malignant degree of bladder transitional carcinoma.

目的探讨rasP21和P53表达与膀胱移行细胞癌病理分级、临床分期、复发、肿瘤大小及患者年龄的关系。方法采用免疫流式细胞光度术与病理学相结合的方法对47例膀胱移行细胞癌细胞rasP21和P53蛋白表达进行检测分析。结果rasP21和P53阳性表达率随病理分级升高而渐升高(P<0.05)。T2~T4期rasP21、P53的阳性表达率高于T1期(P<0.05)。rasP21阳性者复发率为51.6%(16/31),阴性者12.5%(2/16),P53阳性者复发率为45.7%(16/35),阴性者16.6%(2/12)。rasP21、P53的阳性表达率与肿瘤大小及患者的年龄无统计学差异。结论rasP21和P53的表达可反映膀胱移行细胞癌的恶性程度和预后,可作为临床上有价值的指标

Objective To study immune function of erythrocytes and the correlation with the change of T lymphocyte subsets in the patients with bladder cancer. Methods The red blood cell C 3b receptor rate (C 3bRR), immune complex rate (ICR) and four kinds of tumor erythrocyte rosette tests were determined in 34 cases of bladder transitional epithelial carcinoma.The subsets of T lymphocyte were also determined by using flow cytometry (FCM). 30 noncarcinoma patients that well matched in age and 20 healthy...

Objective To study immune function of erythrocytes and the correlation with the change of T lymphocyte subsets in the patients with bladder cancer. Methods The red blood cell C 3b receptor rate (C 3bRR), immune complex rate (ICR) and four kinds of tumor erythrocyte rosette tests were determined in 34 cases of bladder transitional epithelial carcinoma.The subsets of T lymphocyte were also determined by using flow cytometry (FCM). 30 noncarcinoma patients that well matched in age and 20 healthy men were determined for comparison. Results The C 3bRR, four kinds of tumor erythrocyte rosette rate, CD3, CD4 and CD4/CD8 ratio were lower in the bladder transitional epithelial carcinoma group than those of the control group.Meanwhile, ICR and CD8 were significantly elevated ( P <0 01). There was differentiation between G1 patients and G2 patients( P <0 05). A positive correlaion between C3bRR and the radio of CD4/CD8 was noted in the bladder transitional cell carcinoma group. Conclusions Patients with bladder transitional cell carcinoma show lower erythrocyte function and disorder of T lymphocyte subsets. There is a close relationship between red cell immune function and T lymphocyte subsets. The cellular immune function (including the red cell immune function) in patients with poorly differentiated cells is lower.

目的探讨膀胱肿瘤患者的红细胞免疫功能状态及与T淋巴细胞亚群改变的关系。方法测定34例膀胱移行细胞癌患者的红细胞Ⅰ型补体受体花环率(C3bRR)、免疫复合物花环率(ICR)及4项肿瘤红细胞花环率[直向肿瘤红细胞花环试验(DTER)、促肿瘤红细胞花环试验(ETER)、协同肿瘤红细胞花环试验(ATER)及自然肿瘤红细胞花环试验(NTER)],同时用流式细胞仪(FCM)检测T细胞亚群,与年龄相近的30例非肿瘤患者作比较,并测定了20例健康献血员的红细胞免疫指标作对照。结果膀胱移行细胞癌组C3bRR降低,ICR增高,4项肿瘤红细胞花环率均降低,T淋巴细胞亚群CD3及CD4/CD8比值都低于非肿瘤组。细胞分化Ⅰ级组与Ⅱ级组比较有差异。膀胱移行细胞癌组C3bRR与CD4/CD8比值呈正相关。结论膀胱移行细胞癌患者红细胞免疫功能低下,T淋巴细胞亚群比例失调,两者关系密切。细胞分化差的患者细胞免疫功能(包括红细胞免疫功能)更差。膀胱肿瘤术后复发率高可能与细胞免疫功能低下有关。

 
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