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  electric activity
Effects of Pineal-Gland Peptides on the Electric Activity of Pinealocytes in Rats
      
Sprouting and Electric Activity Parameters of the Rat Sensorimotor Cortex after Damaging a Symmetric Part of the Contralateral H
      
The Biphasic Effect of L-DOPA on the Electric Activity of an Isolated Dopaminergic Neuron
      
Rearrangements of the Total Electric Activity of the Cerebral Cortex and Subcortical Structures in Experimental Hypoxia
      
The degree of the changes in electric activity is correlated with the decrease in oxygen tension in the arterial blood.
      
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  electrical activity
Neurotoxic Effects of Fullerenes on the Electrical Activity of Surviving Sections of the Rat Brain Olfactory Cortex
      
Electrical Activity of the African Catfish Clarias gariepinusduring Ontogeny
      
Pulse Electrical Activity of the Statocyst Receptors of the Snail Helix lucorumExposed to Weightlessness at the Orbital Space St
      
The S* waves separating the uncharged medium and a gas with high electrical activity in the presence of an electrical field were studied in [3].
      
Electrical activity of the triceps surale muscle under static load in patients with chronic peripheral circulatory insufficiency
      
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  electro-activity
Species with electro-activity produced in the process of electrode reaction adsorbs on the electrode surface.
      


Two major fractions from the elua-tes of gel filtration of Sephadex G-10, "13" and "29" containing materials with affinity for opiate receptors have been extracted from human brains. Based on chromatographic feature and preliminary chemical investigations, fraction "13" was found probably to be an enkephalin or its related compound. Fraction "29" arbitrarily named "Kephinin", showed several properties characeteristic of opiates. The Rf values of high-voltage electrophoresis and thin layer chromatography of "Kephinin"...

Two major fractions from the elua-tes of gel filtration of Sephadex G-10, "13" and "29" containing materials with affinity for opiate receptors have been extracted from human brains. Based on chromatographic feature and preliminary chemical investigations, fraction "13" was found probably to be an enkephalin or its related compound. Fraction "29" arbitrarily named "Kephinin", showed several properties characeteristic of opiates. The Rf values of high-voltage electrophoresis and thin layer chromatography of "Kephinin" were different from those of leucine-enkepha-in. It inhibited the twitch tension of the electrically stimulated mouse vas-deferens, and this inhibition was rever sed and blocked by the opiate antagonis naloxone. It showed analgesic effect in rabbits during ventriculo-injections, and this effect could be reversed by naloxone. "Kephinin" interacted wit opiate receptors and inhibited the stereo specific binding of tritum-labelled dihydromorphine to synaptic membranes from rat brain. No activity of "Kephinin" was detected when it was incubated with chymotrypsin at 37℃. "Kephinin" was found not only in the human brain but also in the brains of rats and rabbits. It is probably that "Kephinin" is a new peptide with the activity of morphine like substance.

我院针刺麻醉原理的研究是多学科协作进行的。从1975年开始,对内啡肽及其与针刺镇痛的关系进行了多方西的探索。我们在这里选载的一组关于针麻原理研究的论文和报导,就是这一课题研究的初步成果。主要包括。(1)从人及动物脑内提取到一种具有抗痛作用的吗啡样物质,它可能是一种新的内啡肽;(2)用纳洛酮等阿片受体阻断剂作为分析手段,以动物的行为反应、皮层诱发电活动、肢体血管容积及生化反应(脑内cAMP水平)等为指标,从受体的研究水平上来说明针刺镇痛和针刺抗内脏牵拉反应同内啡肽有关;(3)测定人脑脊液及动物脑内中央灰质淡流液中的内啡肽含量,观察到针刺镇痛时脑内内啡肽释放增加。从而,就在神经细胞突触前和突触后这样的水平上初步揭示了内啡肽系统同针刺镇痛的关系。 几年来,我们还同兄弟单位协作,围绕着脑内有关抗痛的结构、物质、功能系统等中心课题,通过大量动物实验和临床观察,证明脑内的尾核是针刺镇痛中起着重要作用的一个环节,尾核内的胆碱能神经细胞的活动参与针刺镇痛过程。此外,对尾核和脑内其他有关结构的形态同功能的联系以及尾核内一些已知递质在针刺镇痛中的作用等方面,都进行了一定的观察和研究,有关论文将另行选登。

Coriaria Lactone is the active constituent of Loranthus on Coriaria SinicaMaxim., which is an effective drug for Schizophrenia. Since 1969, theextract of the active constituents of Loranthus on coriaria sinica Maxim.has been studied in Sichuan Medical College with animal experiments andclinical investigations. In the treatment of Schizophrenia, Coriaria Lactone has exhibited a definiteeffect similar to insulin or electricshock and chlorpromazine. Furthermore,it has the advantages of rapid therapeutic effects,...

Coriaria Lactone is the active constituent of Loranthus on Coriaria SinicaMaxim., which is an effective drug for Schizophrenia. Since 1969, theextract of the active constituents of Loranthus on coriaria sinica Maxim.has been studied in Sichuan Medical College with animal experiments andclinical investigations. In the treatment of Schizophrenia, Coriaria Lactone has exhibited a definiteeffect similar to insulin or electricshock and chlorpromazine. Furthermore,it has the advantages of rapid therapeutic effects, short hospitalization, lowcost, wide sources etc。 The influence of Coriaria Lactone on EEG of 26 rabbits has been dis-cussed preliminarily in a preteding report。On the basis of the precedingexperiments, the authors attempted to maintain abnormally highfrequencydischarges (epilepsy type) which may regulate the cerebral cortex function,decrease untoward reactions and increase the safety of using CoriariaLactone in the treatment of Schizophrenia. Therefore, three antiepilepticdrugs, e .g. primidone, sodium phenytoin and diazepam were examined in ani-mal experiment and their influences on rabbits' EEG, behavior reactiom andLD_(50) of mice caused by Coriaria Lactone were investigated. Results: (1) Primidone and Diazepam could antagonize the behaviorreaction of epilepsy and increase LD_(50) caused by Coriaria Lactone. (2)Primidone had no influence on epilepsy type of EEG, Diazepan causedthe disapearance of epilepsy type of EEG。(3) Sodium Phenytoin had noinfluence on epilepsy type of EEG and did not antagonize behavior reac-tion of epilepsy, but decreased LD_(50). It is considered that Primidone is the most effective of the three drugsagainst the untoward reactions of Coriaria Lactone。

作者观察了扑痫酮、苯妥英钠、安定三种抗癫痫药对马桑内酯引起的家兔脑电活动、行为反应及小白鼠半数致死量的影响。结果表明,以上三种药物,在用于对抗马桑内酯引起的不良反应方面,以扑痫酮较好。

The methyl-eugenol is an active principle isolated from the essential oil of Asarum forbesii Maxium. Pharmacological studies showed that methyl-eugenol had marked depressant effect on central nervous system.It was found to potentiate the hypnotic action of pentobarbital and thiopental and the central depressant effect of chlorpromazine. When injected intravenously, methyleugenol showed narcotic effect in rabbits, cats, dogs and monkeys. It caused disappearence of righting-reflex, pain sensation and hearing reflex...

The methyl-eugenol is an active principle isolated from the essential oil of Asarum forbesii Maxium. Pharmacological studies showed that methyl-eugenol had marked depressant effect on central nervous system.It was found to potentiate the hypnotic action of pentobarbital and thiopental and the central depressant effect of chlorpromazine. When injected intravenously, methyleugenol showed narcotic effect in rabbits, cats, dogs and monkeys. It caused disappearence of righting-reflex, pain sensation and hearing reflex and slowness of corneal reflex. Average narcotic time with methyl-eugenol varied with different species; rabbits (50mg/kg)13.9, cats (50mg/kg) 9.0; dogs (40mg/kg) 25.0, and monkeys (80mg/kg) 30/0 minutes. It also exhibited marked inhibition of the spontaneous E E G of the cortex and mid-brain RF.Methyl-eugenol exhibited slight depressant action on the cardiovascular system and decrease of blood pressureby 20~30 mmHg in cats and lowering of body temperature in rats.Rapid administration of the drug or overdosage brought about depressant action on respiration (decreased in frequency or even stopp) but it may quickly recover.It may be concluded that methyl-eugenol possesses narcotic action which is similar to commonly used short-acting anaesthetics.

甲基丁香酚(metliyl eugenol)为马辛(Asarum forbesii Maxim)挥发油提得的一个纯品,具有明显的中枢抑制作用:(1)协同中枢抑制药的效应;(2)对多种动物均能产生麻醉作用,且随着剂量变化而麻醉时间长短不同;(3)能抑制免大脑皮层及中脑网状结构的自发脑电活动。此外,给药过快或剂量过大可出现呼吸减慢或停止,但能迅速恢复。持续给药1~2小时或多次给药后进行血象、肝肾功能及各脏器的病理切片等检查,结果除白细胞略有上升外其它均属正常。

 
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