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None of the new compounds showed affinity for 5-HT2A and 5-HT2C subtypes, but some of them displayed antagonistic activity in rat stomach fundus at micromolar concentrations.
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The library has been tested against Leishmania donovani and Plasmodium falciparum, with activity at the micromolar level.
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Two of the synthesized compounds proved to be effective in inhibiting HIV-1 replication at micromolar concentrations.
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Stimulation of NPP hydrolysis by micromolar concentrations of aluminium and copper as well as by millimolar concentrations of magnesium decreased in the presence of 25 μM cAMP.
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It was found that this inhibitor in a micromolar concentration range (2-20 μM) induced in a dose-dependent manner H2O2 generation by human neutrophils and the release of lysozyme from the cells.
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