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   肾小球疾病 在 泌尿科学 分类中 的翻译结果: 查询用时:0.605秒
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肾小球疾病     
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  glomerular disease
The second area of focus is on the pathogenesis of glomerular disease.
      
Glomerular disease in the elderly: incidence and clinicopathologic findings.
      
Glomerular disease in the elderly is frequently attributed to a preexisting or extrarenal disease, and the true incidence of this kind of pathology is yet to be determined.
      
It is concluded that better understanding of the pathophysiology of the mesangium would be valuable for designing more effective diagnostic and therapeutic approaches to patients with glomerular disease.
      
In certain diseases, especially primary glomerular disease, the beneficial effect seems proven.
      
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  glomerular diseases
There is an increasing recognition of the association between chronic hepatitis C virus (HCV) infection and glomerular diseases.
      
There is an increasing recognition of the association between chronic hepatitis C virus infection and glomerular diseases.
      
The most common glomerular diseases are focal segmental glomerulosclerosis and immune complex glomerulonephritis.
      
Minimal change disease (lipoid nephrosis), (60, 12%), membranous glomerulonephritis (51, 10.2%) and focal proliferating glomerulonephritis, (excluding lupus nephritis and IgA nephropathy), (59, 11.8%) were the three most common glomerular diseases.
      
We believe that the relatively high incidence of these three glomerular diseases occuring in the elderly can be explained by the increase in the incidence of malignancies and/or by the increased use of a variety of drugs.
      
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  glomerulopathy
Glomerular disorders include IgA nephropathy, cryoglobulinemia, amyloidosis, and a lupus-like immune complex glomerulopathy.
      
Studies in patients with diabetic glomerulosclerosis also have provided evidence as to the importance of achieving the low blood pressure goal to slow the progression of the glomerulopathy.
      
Minimally and slightly changed glomeruli from six patients affected with focal-sclerosing glomerulopathy (glomerulonephritis) were examinated with the electron microscope.
      
Therefore focalsclerosing glomerulopathy (glomerulonephritis) must be understood as a diffuse process with focal (and segmental) accentuation.
      
In 3/18 a mild glomerulopathy existed before hyperthermia, as deduced from a glomerular pattern despite a quantitatively physiological proteinuria, leading in all 3 to pathological proteinuria during hyperthermia.
      
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  其他


CICs were determined in 92 children with glomerular diseases by PEG precipitation-complement consumption (PEG-CC) test. The frequency (27 out of 34) as well as the serum level of CIC in APGN was found to be the highest among various glomerular diseases and was paralleled to the activity of the disease. Out of 13 children with upper respiratory infection (URI without glomerular disease) 4 proved to be CIC positive. The CIC lasted longer in patients with APGN than that of URI. The renal biopses were performed...

CICs were determined in 92 children with glomerular diseases by PEG precipitation-complement consumption (PEG-CC) test. The frequency (27 out of 34) as well as the serum level of CIC in APGN was found to be the highest among various glomerular diseases and was paralleled to the activity of the disease. Out of 13 children with upper respiratory infection (URI without glomerular disease) 4 proved to be CIC positive. The CIC lasted longer in patients with APGN than that of URI. The renal biopses were performed in 12 patients with glomerular diseases. CICs were detected in 4 out of 7 patients who had evidence of deposition of immune complex in glomerulus. On other hand, in 5 patients without the evindenee of deposition of immune complex only 1 patient proved to be CIC positive.

本文采用聚乙二醇沉淀-补体消耗法测定了92例不同类型肾小球疾病患儿的循环免疫复合物(CIC)。在各类肾小球疾病中急性感染后肾炎(APGN)患儿的CIC阳性率(27/34)及血清水平均最高,且与APGN的疾病活动性有关。13例患上呼吸道感染的患儿(无肾小球疾病)中4例CIC阳性。APGN患儿的CIC持续时间明显长于上呼吸道感染患儿。12例患儿做了肾穿刺活检,其中7例肾小球证明有免疫复合物沉积的病例中4例CIC阳性,而5例肾小球无免疫复合物沉积的病例中仅1例CIC阳性。

73 cases of primary nephropathy and 53 cases of acute nephritis were examined for HBsAg the positive rates were 17.8% and 18.8% respectively, comparatively speaking, higher than that of normal population in the same district. We thus suspect hepatitis B virus probably to be one of the causes of primary glomerulopathy, clinical analysis of those patients tells: In nephritis cases, naked eye hematuria was the main clinical feature, the enlargement of liver with a given degree of impairment of liver function may...

73 cases of primary nephropathy and 53 cases of acute nephritis were examined for HBsAg the positive rates were 17.8% and 18.8% respectively, comparatively speaking, higher than that of normal population in the same district. We thus suspect hepatitis B virus probably to be one of the causes of primary glomerulopathy, clinical analysis of those patients tells: In nephritis cases, naked eye hematuria was the main clinical feature, the enlargement of liver with a given degree of impairment of liver function may be accompanied, they usually ran a long course with recurrent relapses. Those with nephrosis, mostly belong to nephritic pattern, were insensitive to adrenocortical. hormone therapy. According to what mentioned above, we propose those with pesistent positive HBsAg should undergo repeated routine urine and renal function examinations; concurrently, cases with nephrosis or nephritis should be examined for HBsAg routinely. Biopsy of both liver and kidney seems to be necessary in order to unfold the relationship between the two.

本文对73例原发性肾病和53例急性肾炎患儿进行了HBsAg的检测,其阴性率分别为17.8%和18.8%,与本地区正常人群HBsAg普查结果相比,明显升高,从而怀疑乙肝病毒有否可能为原发性肾小球疾病的病因之一,(其通过免疫反应而引起乙型肝炎相关性肾炎)。临床分析表明:肾炎者以内眼血尿为主要临床表现,可伴有肝大和不同程度的肝功能损害,病程迁延,常反复发作;表现为肾病者,则多属于肾炎性肾病,对激素治疗不敏感。作者建议今后对HBsAg持续阳性的患儿应反复检查尿常规和肾功能,对肾病,肾炎患者应常规查HBsAg,并争取多开展肝、肾组织的活检,以进一步揭示两者之间的联系。

Serum and urine *2-microglobulin, serum oreatinine and endogenous oreatinine clearance were measured simultaneously in 62 patients with primary glomerular diseases. The results of this study showed that there was a positive correlation between serum *2-microglobulin and serum creatinine, while serum *2-microglobulin concentrations were inversely proportional to the oreatinine clearance. Measuring *2-microglobulin concentration is a simple, sensitive and accurate method for detecting minor degrees of renal impairment....

Serum and urine *2-microglobulin, serum oreatinine and endogenous oreatinine clearance were measured simultaneously in 62 patients with primary glomerular diseases. The results of this study showed that there was a positive correlation between serum *2-microglobulin and serum creatinine, while serum *2-microglobulin concentrations were inversely proportional to the oreatinine clearance. Measuring *2-microglobulin concentration is a simple, sensitive and accurate method for detecting minor degrees of renal impairment. However, one should bear in mind to rule out some non-renal diseases, such as connective tissue diseases, malignant lymphoma and multiple myeloma and so on, in the use of *2-microglobulin as a marker for estimation of renal function.

本文报告62例原发性肾小球疾病患者血清及尿β_2-微球蛋白、血清肌酐和内生肌酐清除率的测定结果。本文资料表明:血清β_2-微球蛋白与血清肌酐呈正相关,而与内生肌酐清除率呈负相关;β_2-微球蛋白是一个简单而又灵敏反映轻度肾功能损害的检测指标;以β_2-微球蛋白评价肾功能时,必须除外结缔组织疾病、恶性淋巴瘤及多发性骨髓瘤等疾病的影响。

 
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