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|  | | 为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法,我们为您准备了出自英文原文的大量英语例句,供您参考。 | |
Analysis of Polymorphisms of the Huntington Disease Gene in Ethnic Populations of the Volga-Ural Region
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Proteins with a long polyglutamic tract synthesized in the cells of patients with dentato-rubral and pallido-luysian atrophy, myotonic dystrophy and Huntington disease interfere with transcription on the nuclear matrix.
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To establish better the cellular localization of these and related parameters in human brain, we have examined their alterations in two well-characterized selective neurodegenerative disorders, Huntington Disease (HD) and Alzheimer Disease (AD).
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Intergeneration CAG expansion in a Wuhan juvenile-onset Huntington disease family
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Huntington disease, spinobulbar muscular atrophy, and the autosomal dominant cerebellar ataxias are examples of autosomal dominant disorders caused by the expansion of trinucleotides (CAG) within disease genes.
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| | Using the technology of polymerase chain reaction and polyacrylamide gel electrophoresis,we examine the number of CAG Triplets in IT15 gene directly,then we can give an early and exact gene diagnosis for Huntington disease.We examined 11 persons who come from a HD family. The result shows that 4 of total 5 high risk members carry the HD gene. | | 为了对Huntington舞蹈症进行早期准确的基因诊断,作者应用聚合酶链反应直接检测IT15基因CAG三核苷酸重复序列,对武汉某Huntington舞蹈症(HD)家系两代11名家庭成员进行了基因诊断。PCR产物的取丙烯酰胺凝胶电脉结果显示5例HD高风险者有4例携带异常HD基因。 | | 文摘来源 | |   |
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