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六合维生素
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  hexavitamin
     Bioavailability study and pharmacokinetic analysis on three dosage forms of riboflavin oral preparation, namely, conventional tablet (IA), hexavitamin pill coated with a gelatin shell (IB) and a sustained-release tablet (IC) were carried out in nine healthy human volunteers by using urinary excretion method. All the three dosage forms were administered in 16 mg single dose immediately after a light breakfast.
     本文用尿排药法,将三种核黄素(R)制剂给9个志愿者顿服15mg后,研究其生物利用度,并作药物动力学分析。 三种制剂为普通片(IA)、包有软明胶皮的六合维生素丸(IB)以及一种长效缓释片剂(IC)。
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  “六合维生素”译为未确定词的双语例句
     Determination of three vitamins B in Six Vitamins Pills by HPLC
     高效液相色谱法测定六合维生素丸中3种B族维生素含量
短句来源
     Objective:To develop an HPLC method for the determination of three vitamins B in six Vitamins Pills.
     目的:采用离子对反相高效液相色谱法测定六合维生素丸中烟酰胺、维生素B2、维生素B13种水溶性维生素的含量。
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  相似匹配句对
     ON THE SYNTHESIS OF METHIONINE METHYL SULFONIUM SALTS(VITAMIN U)
     维生素U的合成
短句来源
     Naturals vitamin E
     天然维生素E
短句来源
     Determination of three vitamins B in Six Vitamins Pills by HPLC
     高效液相色谱法测定六合维生素丸中3种B族维生素含量
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     Development of Liuhe Liqueur
     六合酒的研制
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Bioavailability study and pharmacokinetic analysis on three dosage forms of riboflavin oral preparation, namely, conventional tablet (IA), hexavitamin pill coated with a gelatin shell (IB) and a sustained-release tablet (IC) were carried out in nine healthy human volunteers by using urinary excretion method. All the three dosage forms were administered in 16 mg single dose immediately after a light breakfast. A bioavailability reference standard was set up by administering a total amount of 16 mg conventional...

Bioavailability study and pharmacokinetic analysis on three dosage forms of riboflavin oral preparation, namely, conventional tablet (IA), hexavitamin pill coated with a gelatin shell (IB) and a sustained-release tablet (IC) were carried out in nine healthy human volunteers by using urinary excretion method. All the three dosage forms were administered in 16 mg single dose immediately after a light breakfast. A bioavailability reference standard was set up by administering a total amount of 16 mg conventional tablets (6 mg each) in 3 divided doses (IIA) immediately after each meal. The results of recovery rate of riboflavin from the urine showed that IIA gained the highest percentage, being 67.62%., while IA, IB and 10 were 62.09%, 61.7% and 47.12% respectively.The above results indicated that there was no difference in bioavailability (bioe-quivalent) between IIA and IA, and that the bioavailability of the fast-release dosage-forms is superior to the slow-release dosage forms.The results obtained from pharmacokinetio analysis showed that there were no distinct differences amoung IA, IB and IC in elimination rate constants, however, distinct differences existed in the absorption rate constants and time needed to reach the maximun concentration.

本文用尿排药法,将三种核黄素(R)制剂给9个志愿者顿服15mg后,研究其生物利用度,并作药物动力学分析。三种制剂为普通片(IA)、包有软明胶皮的六合维生素丸(IB)以及一种长效缓释片剂(IC)。另外,口服R片剂(IIA),5mg,日服三次,作为生物利用度的参比标准。尿中R的回收率以IIA为最高,达67.52%,IA、IB、IC分别为62.09、51.7和47.12%。从以上结果可见:①IIA与IA为生物等效性,这表明普遍使用的给药方案(5mg,日服三次)从生物利用度观点来看,可以简化为15mg日服一次,②释药迅速的制剂较缓释制剂(明胶包衣的丸剂、缓释片剂)为优。六合维生素丸中的核黄素,生物利用度较差。对IA、IB、IC的药物动力学分析,结果显示消除速度常数β无显著差异,但吸收速度常数K。及达峰时t_m均有显著差异。

Objective:To develop an HPLC method for the determination of three vitamins B in six Vitamins Pills.Methods:C 18 column was used. The mobile phase consisted of 0.005 mol/L sodium heptanesulfonate (containing 0.5% glacial acetic acid and 0.05% triethylamine)–methanol(72∶28), the flow rate was 1.0ml/min. The UV detector wavelength was 260nm. Results:The calibration curves showed good linearity in the range of 0.3154~15.7700μg for nicotinamide,0.05227~2.6135μg for vitamin B2,0.4474~22.3700μg for vitamin B1....

Objective:To develop an HPLC method for the determination of three vitamins B in six Vitamins Pills.Methods:C 18 column was used. The mobile phase consisted of 0.005 mol/L sodium heptanesulfonate (containing 0.5% glacial acetic acid and 0.05% triethylamine)–methanol(72∶28), the flow rate was 1.0ml/min. The UV detector wavelength was 260nm. Results:The calibration curves showed good linearity in the range of 0.3154~15.7700μg for nicotinamide,0.05227~2.6135μg for vitamin B2,0.4474~22.3700μg for vitamin B1. Conclusion:This method developed is convenient and reliable and could be used for quality control of Six Vitamins Pills.

目的:采用离子对反相高效液相色谱法测定六合维生素丸中烟酰胺、维生素B2、维生素B13种水溶性维生素的含量。方法:以C18为色谱柱,0.005mol/L庚烷磺酸钠溶液(含0.5%冰醋酸和0.05%三乙胺)-甲醇(72∶28)为流动相,流速为1ml/min,检测波长为260nm。结果:烟酰胺、维生素B2、维生素B1的线性范围分别为0.3154~15.7700μg、0.05227~2.6135μg、0.4474~22.3700μg;方法的回收率在97.5%~99.2%,RSD为1.3%~1.8%。结论:本法简便,快速,为六合维生素丸产品的质量控制及多维类药物中水溶性维生素含量的测定提供了可靠依据。

 
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