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   环孢素a 在 泌尿科学 分类中 的翻译结果: 查询用时:1.514秒
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心血管系统疾病
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内分泌腺及全身性疾病
皮肤病与性病
基础医学
眼科与耳鼻咽喉科
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环孢素a     
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  cyclosporine a
Induction of apoptosis by HCA was partially prevented by BAPTA, N-acetylcysteine or cyclosporine A.
      
The study included 25 RT patients (mean 5.4±2.7 yrs after the transplantation, 10 females and 15 males) treated with immune suppressive therapy including cyclosporine A, azathioprine and prednisolone.
      
The edeines analogs were tested in several in vitro and in vivo assays using the mouse model, with edeine B (peptide W1) and cyclosporine A as reference compounds.
      
Paclitaxel and cyclosporine A show supra-additive antiproliferative effects on smooth muscle cells by activation of protein kina
      
We intended to establish a pharmacologic concept of synergistic antiproliferative effects on smooth muscle cells (SMC) by using paclitaxel and cyclosporine A at clinically applicable doses.
      
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  cyclosporin a
The rate of the Ca2+ release was proportional to the Ca2+ load, insensitive to cyclosporin A and to Na+, inhibited by La3+, TPP+, Pi, and nigericin, while being activated by spermine.
      
Cyclosporin A prevented the time-dependent decrease in the Ca2+ capacity of mitochondria but did not affect internucleosomal DNA fragmentation.
      
All the effects of FeSO4 + ascorbate were essentially prevented by cyclosporin A, a specific inhibitor of the mitochondrial Ca2+-dependent pore (also known as the mitochondrial permeability transition).
      
We hypothesize that oxidative stress induced in vitro with FeSO4 and millimolar concentrations of ascorbate damages mitochondria by inducing the cyclosporin A-sensitive Ca2+-dependent pore in the inner mitochondrial membrane.
      
Induction of a Ca2+,cyclosporin A-sensitive pore in mitochondria completely suppressed the lucigenin-derived chemiluminescence (LDC).
      
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  cyclosporine-a
The cyclosporine-A-sensitive mitochondrial permeability transition pore in winter wheat at a low temperature and under oxidative
      
Calcineurin inhibitors, cyclosporine-A (5?mg/kg) and FK506 (3.5?mg/kg), reduced %IS/AR (27.4?±?4.4% and 29.9?±?3.4%, respectively).
      
The protective effects of these calcineurin inhibitors were inhibited by PD98059, and the combination of DADLE with cyclosporine-A or FK506 did not afford further cardioprotection.
      
Release of the hydrophobic cyclosporine-A from microspheres was however much more sustained and near zero-ordered, discharging 60% in 70 days.
      
Following oral administration of cyclosporine-A (10 and 30 mg/kg), venous responses to bradykinin were attenuated while those to enalaprilic acid remained unchanged.
      
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  effects of cyclosporine a
Effects of cyclosporine A on angiotensin II-induced cardiomyocyte hypertrophy in neonatal rats
      
The effects of cyclosporine A (CsA) on Angiontensin II (Ang II)-induced protein contents, c-fos protein levels and cytosolic Ca2+ level ([Ca2+]i) in cultured cardiomyocytes of neonatal rats were observed.
      
Effects of cyclosporine A on the process of vascularization of freely transplanted islets of Langerhans
      
In order to look at the effects of Cyclosporine A on the mechanisms of rejection after xenogeneic heart transplantation, the model of heterotopic intrathoracic cardiac transplantation was used.
      
Further improvement of results can be expected with better control, especially of the side effects of cyclosporine A.
      
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Cyclosporine A(C_sA)was used in 240 cases of re- nal transplantation in our hospital from February,1985 to September,1990.Of the 240 patients,12 were found to develop spontaneous rupture of the grafted kidney(in- cluding 5 cases of renal vascular rupture)with an inci- dence rate of 5%.The etiology,diagnosis and principle of treatment are briefly discussed.

我院自1985年2月——1990年9月,在尸肾移植应用环孢素 A(CsA)240例次中,发现移植肾自发性破裂12例(含移植肾血管破裂5例),发生率为5.0%。本文对其发生原因、诊断及处理原则作简单讨论。

In this paper, the method of cultured rat mesangial ceils (Ms ceils) and morphologic analysis of Ms cells with DMPS membrane were firstly established. The effect of Cyclosporine A (CsA)on the Ms cells contraction and the protection of Ms cells from CsA toxicity using platelet-activating factor (PAF) antagonist-BN52021 were observed. In results, CsA induced Ms cells contraction in time and concentration dependent manner. CsA (10~(-9)M) also had the effect and lasted half an hour. Twenty minutes after removing...

In this paper, the method of cultured rat mesangial ceils (Ms ceils) and morphologic analysis of Ms cells with DMPS membrane were firstly established. The effect of Cyclosporine A (CsA)on the Ms cells contraction and the protection of Ms cells from CsA toxicity using platelet-activating factor (PAF) antagonist-BN52021 were observed. In results, CsA induced Ms cells contraction in time and concentration dependent manner. CsA (10~(-9)M) also had the effect and lasted half an hour. Twenty minutes after removing of CsA from cells, the Ms cells could recover from their contracting states. Ms cells contraction induced by CsA was significantly inhibited by PN52021, at 5×10~(-5)M. The results indicate: 1) The effect of CsA induced Ms cells contraction is reversible and the contraction of Ms cells can reduce renal blood ilow and glomerular capillary kf in rive. 2) PAF may take part in the cell contraction in some way. PAF antagonist BN52021 has the effect on prophylaxis and treatment of CsA nephrotoxicity.

本文采用SD大鼠肾脏系膜细胞培养及硅胶膜形态分析技术。研究环孢素A(CsA)诱导肾系膜细胞收缩作用及血小板活化因子拮抗剂BN52021对CsA诱导作用的抑制效应。结果示CsA引起系膜细胞收缩呈现时间和剂量依赖效应,其作用可逆。BN52021浓度为5×10~(-5)M时,可显著地抑制CsA的诱导作用。结果提示CsA通过可逆性诱导系膜细胞收缩引起肾小球毛细血管血流量和超滤系数(Kf)下降;血小板活化因子可能参与了这个过程,使用血小板活化因子拮抗剂可能有预防及治疗CsA肾毒性的作用。

Cadaveric renal transplants for 768 cases, 800 times had been completed in their hospital within 14 years, from June 1978 to June 1991. the author reported. The grafts survival rate of 1. 3. 5 years were 77.8%, 73.5% and 52.6% respectively. 8 cases survived for more than 10 years. Dealing with retrospective review of clinical data of this series, several problems concerning grafts survival were discussed. For the purpose of great forging of clinical transplantation, author hold that as follows: Factors concerning...

Cadaveric renal transplants for 768 cases, 800 times had been completed in their hospital within 14 years, from June 1978 to June 1991. the author reported. The grafts survival rate of 1. 3. 5 years were 77.8%, 73.5% and 52.6% respectively. 8 cases survived for more than 10 years. Dealing with retrospective review of clinical data of this series, several problems concerning grafts survival were discussed. For the purpose of great forging of clinical transplantation, author hold that as follows: Factors concerning improvement of survival rate were multifarious. ①High quality procuration and transplantation of the donor kidneys were most important. ②In the era of CsA, ABO typing and lymphocyte toxicity test must be persisted. ③Infection still was an important cause of transplant failure. Prevention of infection ought to put into effect before, during and after operation. ④Postoperative following up should be reinforced. Guide the patients' persistent remedy in their convalescence. It possesses great significance for long term surviving.

作者报道1978年6月至1992年6月间施行的尸体肾移植768例800次。全组的肾存活率:1年为77.8%3年为73.5;5年为52.6%;存活10年以上者8例。从本组临床资料回顾性分析显示:①提高肾存活率的因素中高质量取肾与植肾手术尤为重要;②在当今环孢素A应用的时代,仍应坚持ABO血型及淋巴细胞毒性试验配型工作;③感染是移植失败的重要原因,应将预防感染贯彻于术前、术中及术后的全过程;④加强对肾移植患者的随访工作,指导患者的康复,这对移植肾能否长期存活有着重要意义。

 
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