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癌胚胎的
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  oncofetal
α-Fetoprotein (AFP) is a major mammalian oncofetal protein, which is also present in small quantities in adults.
      
Simultaneously, the expression of embryo-specific genes is unblocked, leading to overexpression of embryonic antigens and their abnormal secretion into blood, which results in appearance of oncofetal serum markers.
      
Carbohydrate antigens as oncofetal antigens in papillary carcinoma of the thyroid gland
      
The aim of the study was to establish whether the previously reported expression of carbohydrate antigens in thyroid carcinomas represents a "de novo" expression or a form of the so-called oncofetal expression.
      
Immune cytolysis of human malignant melanoma by antibody to oncofetal antigen I (OFA-I)
      
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Twenty- eight cases of immature teratoma(IT ) of the ovary were studied with histopathological method.All specimens were stained immunohis-tochemically with CE, AFP and AAT. The value of histological and immunohis-tochemical features of the IT were analyzed in the diagnosis and differential diagnosis. The factors influencing the prognosis were also discussed.

对28例卵巢未成熟畸胎瘤(ImmatureTeratoma,IT)进行组织病理学检查与癌胚胎抗原(CEA)、甲种胎儿球蛋白(AFP)和d1一抗胰蛋白酶(AAT)免疫组织化学染色,讨论了组织病理学和免疫组织化学特征在诊断和鉴别诊断中的价值;结合临床资料探讨了影响肿瘤患者预后的因素。

Immunohistochemical LSAB technique was used in differential diagnosis of malignant small round cell tumors(MSRCT), whose pathological characters were difficult to be defined by common methods.As a result, 78 of 79 cases were ultimately diagnosed as malignant lymphoma,undifferentiated cancer,amelanotic malignant melanoma,embryonal rhabdomyosarcoma,Ewing's tumor of soft tissue,neuroblastosarcoma,spermocytoma and undefined sarcoma,respectively.It suggests that many different markers shown by immunohistochemical...

Immunohistochemical LSAB technique was used in differential diagnosis of malignant small round cell tumors(MSRCT), whose pathological characters were difficult to be defined by common methods.As a result, 78 of 79 cases were ultimately diagnosed as malignant lymphoma,undifferentiated cancer,amelanotic malignant melanoma,embryonal rhabdomyosarcoma,Ewing's tumor of soft tissue,neuroblastosarcoma,spermocytoma and undefined sarcoma,respectively.It suggests that many different markers shown by immunohistochemical technique would be very useful to differentiate MSRCT which is similar in shape but originated from different tissues.

应用免疫组化LSAB法,对原病理诊断意见分岐的79例恶性小圆形细胞肿瘤(MSRCT)进行免疫组化鉴别诊断研究。结果除1例仍不能分类外,其余78例(占99%)均得到明确诊断。其中有恶性淋巴瘤、未分化癌、胚胎性横纹肌肉瘤、无色素性恶黑、神经母细胞瘤、精原细胞瘤、骨外尤文瘤及未分化肉瘤。结果表明,采用多种肿瘤标志物联合标记是对不同组织起源而形态相近MSRCT鉴别诊断的有效方法。

Purpose To investigate expression of oncofetal fibronectin(onFN) mRNA in the thyroid pa-pillary carcinoma. Methods The expression of oncofetal fibronectin mRNA in 10 thyroid papillary carcinomas, 12 thyroid adnomas, 9 normai thyroid tissues were detected by using reverse transcription poly-merase chain reaction(RT-PCR). Results The oncofetal fibronectin mRNA expressed in 8 of 10 papillary crcinomas, but not in 12 adenomas, 9 normal thyroid tissues. Conclusions It is suggested that oncofetal fibronectin mRNA,...

Purpose To investigate expression of oncofetal fibronectin(onFN) mRNA in the thyroid pa-pillary carcinoma. Methods The expression of oncofetal fibronectin mRNA in 10 thyroid papillary carcinomas, 12 thyroid adnomas, 9 normai thyroid tissues were detected by using reverse transcription poly-merase chain reaction(RT-PCR). Results The oncofetal fibronectin mRNA expressed in 8 of 10 papillary crcinomas, but not in 12 adenomas, 9 normal thyroid tissues. Conclusions It is suggested that oncofetal fibronectin mRNA, which specially expressed in the thyroid papillary carcinomas, may become a biological marker with potentially clinical value.

目的 探讨癌胚胎纤维连接蛋白mRNA在甲状腺乳头状癌中的表达及其意义。方法 采用RT-PCR技术检测了10例甲状腺乳头状癌,12例腺瘤和9例正常甲状腺组织中的癌胚胎纤维连接蛋白mRNA表达。结果 10例乳头状癌中8例癌胚胎纤维连接蛋白mRNA表达阳性,其他12例腺瘤、9例正常甲状腺表达均为阴性。结论 癌胚胎纤维连接蛋白mRNA在乳头状癌中特异性表达,提示癌胚胎纤维连接蛋白mRNA有可能成为甲状腺乳头状癌的一种分子生物指标,具有一定的潜在性临床应用价值。

 
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