The single cell gel electrophores is(SCGE) was used to detect the breakage of DNA strand and analyze LBP protectio n against oxidation damage in testicle cells treated by different concentrations of LBP for 1hour firstly, and then cultured with 100μmol/L H 2O 2 for 25 min .
Conclusion: Jiusuyu could improve free radical metabolism,resist oxidation damage,adjust vascular contracting-relaxing factor and improve microcirculation of gastric mucosa; it has the effect of protecting gastric mucosa of acute alcoholism mice.
A low level of bcl 2 gene expression could be detected in BEC at basic state, and either VIP or EGF stimulated the transcription of bcl 2, which improved the capability of BEC to resist oxidant injury.
The data suggest that the binding of integrin with extracellular matrix can upregulate activity of antioxidant enzymes, and increase the content of GSH and improve the ability of BECs to resist oxidant injury.
SCGE was used to detect DNA strand breaks and to analyze p tyrosol protection against oxidative damage in CHL cells which were exposed to different concentration of p tyrosol for 1 58h firstly,and then cultured with 0 4mmol/L hydrogen peroxide for 25min.
To study the alteration of cellular antioxidant capability with complex I impairment,human neuroblastoma SH-SY5Y cells were treated by specific mitochondrial complex I inhibitor rotenone and followed by H_2O_2 exposure.
These results suggest that dexrazoxane may protect myocytes against hypoxia-reoxygenation-induced damage by chelating free or loosely bound iron, thus preventing site-specific iron-based oxygen radical damage.
Hydrolyzed dexrazoxane metabolites prevent site-specific iron-based oxygen radical damage by displacing iron from doxorubicin and chelating free and loosely bound iron.
Myocardial stunning, defined as a reversible decrease in contractility after ischemia and reperfusion, may be a manifestation of reperfusion injury caused by free oxygen radical damage.
In diabetic pregnancy, both diabetes and pregnancy are promoting oxygen radical damage.
Because of the physiological importance of IDO in the protection against free oxygen radical damage, a search was conducted to find this enzyme in the eye.