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   膀胱肿瘤 在 基础医学 分类中 的翻译结果: 查询用时:1.449秒
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膀胱肿瘤     
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  bladder neoplasms
    Objective To compare the level of IL-12 and IL-10 secreted by DC sitimulated with CpG-ODN and BCG,and to investigate the role of new immunologic adjuvant CpG-ODN in preventing the recurrence of bladder neoplasms.
    目的比较免疫佐剂卡介苗(BCG)、含CpG序列的寡脱氧核糖核苷酸(CpG-ODN)刺激小鼠骨髓来源的树突状细胞(DC)分泌细胞因子IL-12I、L-10的水平,探讨CpG-ODN在预防膀胱肿瘤复发中的可行性。
短句来源
    Conclusion CpG-ODN stimulation of murine DC cultures results in the production of the Th1 cytokine IL-12,but do not result in concurrent production of the Th2 cytokine IL-10 in contrast to BCG. CpG-ODN may be a potential method to prevent the recurrence of bladder neoplasms.
    结论CpG-ODN可诱导DC产生Th1型细胞因子IL-12,对Th2型细胞因子IL-10影响很小,比BCG更能调节免疫应答向Th1型转换,可能在预防膀胱肿瘤复发的应用中具有良好前景。
短句来源
  bladder tumor
    Thirty three rats were diagnosed to be positive bladder tumor in 37 rats combined with urinary HE and AO pigmentation while the positive ratio is 89.2%.
    在病理确诊的39只大鼠中,有33只联合使用尿HE染色+AO染色诊断为膀胱肿瘤,阳性率89.2%。
短句来源
    Conclusion Bladder tumor induced by MNU is highly resemble with that of human beings in both histologic and pathologic character.
    结论MNU经膀胱灌注诱发膀胱肿瘤动物模型方法简单、药物用量少、诱瘤时间短、致癌率高,其诱发的膀胱肿瘤在组织学和病理学特征上和人的膀胱肿瘤十分相似,是较理想的动物模型。
短句来源
    A New Method of Establishing Model of Orthotopic Mouse Bladder Tumor
    建立小鼠膀胱肿瘤原位模型的一种新方法
短句来源
    EARLY PATHOLOGICAL CHANGES IN BLADDER TUMOR OF MICE INDUCED BY N-METHYL-N-NITRO-N-NITROSOGUANIDINE
    甲基硝基亚硝基胍诱发小鼠膀胱肿瘤早期病变的动态观察
短句来源
  bladder cancer
    RESULTS: All the 25 mice developed bladder cancer after T24 cell inoculation.
    结果:25只裸鼠在种植T24细胞后均形成膀胱肿瘤
短句来源
    1. ObjectiveIntravesical instillation of BCG is one of the most effective treatment and recurrence prevention approach of bladder cancer. However, as the BCG dose are large and Incertitude of curative effect, so this therapy is associated with some complications such as disseminated mycobacteriosis disease,which suggesting that this treatment must be improved.
    一、目的BCG膀胱灌注是治疗膀胱肿瘤防止其复发的最有效方法之一,但目前在治疗中存在着给药量大、疗效不确切、易导致结核播散等并发症,提示着必须对这一方法进行改造。
短句来源
  bladder carcinoma
    Objective To construct the immunotoxin BDI-1-PEA and study its cytotoxicity against human bladder carcinoma in vitro.
    目的 构建新型免疫毒素BDI- 1-PEA ,并进行抗人膀胱肿瘤活性的初步研究测定。
短句来源
    Results Study in vitro indicated that BDI-1-PEA showed stronger selective cytotoxicity against human bladder carcinoma cell line E-J than free PEA or the mixture of BDI-1 and PEA.
    应用四甲基偶氮唑盐 (MTT)法初步检测其对人膀胱肿瘤细胞系E -J的选择性杀伤活性。 结果 BDI- 1-PEA结合物具有高效靶向杀伤膀胱肿瘤细胞的能力 ,优于游离PEA或PEA与BDI- 1的混合物。
短句来源
    Conclusion BDI-1-PEA conjugate is an effective immunotoxin against human bladder carcinoma and is a promising candidate for further clinical study.
    结论 新型免疫毒素BDI- 1-PEA有较高的选择性抗人膀胱肿瘤细胞的活性 ,有较高的研究和应用价值
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      bladder neoplasms
    Molecular studies of bladder neoplasms have identified a series of nonrandom genetic alterations affecting a particular set of oncogenes and tumor-suppressor genes.
          
    Because the modality of therapy for patients with bladder neoplasms primarily depends onmorphological evaluation and clinical staging, the diagnosis carries significant consequences.
          
    The ultrastructure of urothelium from 4 patients with no evidence of tumour was compared with that taken from 22 patients with bladder neoplasms of different grade and stage.
          
    Recommendations for the reporting of urinary bladder specimens containing bladder neoplasms
          
    Urinary bladder neoplasms in Syrian hamsters after administration of N-nitroso-N-methyl-N-dodecylamine
          
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      bladder tumor
    BAK cells have the ability to kill bladder tumor cells, and the antitumor activity of effecter cells was determined by LDH release assay.
          
    The clinical significance of flow cytometric deoxyribonucleic acid measurement of deparaffinized specimen in bladder tumor
          
    A retrospective study of flow cytometric measurements on paraffin-embedded tumor specimens from 188 patients with bladder tumor was conducted.
          
    It was found that the DNA ploid pottern, degree of infiltration and the multiplicity of bladder tumor were closely related with tumor recurrence, among which the DNA ploid pattern was most significant.
          
    He underwent transurethral resection of the prostate and bladder tumor and was found to have PAC with TCC of the bladder and prostate.
          
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      bladder cancer
    Study of recombinant human IFN-α-2b bacilli calmette-guerin activated killer cells and against bladder cancer cell in vitro
          
    Presently, one of the most potent immunotherapies is the application of bacillus Calmette Guerin (BCG) to prevent recurrences of the superficial bladder cancer.
          
    We conclude that the recombinant BCG can activate more PBMCs to anti-bladder cancer in vitro than wild-type BCG does.
          
    Radiotherapy is an Effective Treatment for High-Risk T1-Bladder Cancer
          
    We have evaluated the efficacy of adjuvant radiotherapy or radiochemotherapy on local control, bladder preservation, recurrence rate and long-term survival after TURB of high-risk T1-bladder cancer.
          
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      bladder carcinoma
    TBARS, Carnitine, and Reduced Glutathione Levels in Human Bladder Carcinoma
          
    In this study, we investigated tissue levels of reduced glutathione (GSH) and carnitine as well as thiobarbituric acid reactive substances (TBARS, as a marker of lipid peroxidation) levels in bladder carcinoma and control group of patients.
          
    Cefoperazone was administered to 50 of 139 in-patients suffering from urinary tract infections complicated by underlying diseases such as prostatic adenoma or carcinoma, bladder carcinoma, ureterolithiasis or epididymitis.
          
    Expression of a mutant hTERT in human bladder carcinoma cell line T24 and its clinical significance
          
    After transfecting the fusion gene into bladder carcinoma cell line T24 by calcium phosphate-DNA coprecipitation, the steady expression of GFP-hTERT fusion protein was tested by fluorescent light microscopy.
          
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    Experimental bladder tumors were induced in female mice by intravescical infus- ion of N-methyl-N-nitro-N-nitrosoguanidine.Early changes in the bladder epithelium of mice were studied.Our observations show that the lesions have a typical course of hyperplasia,noninvasive papilloma and invasive carcinoma and the tumors consist of transitical cells.

    本项研究采取膀胱灌注 MNNG 诱发小鼠膀胱肿瘤,对 MNNG 引起膀胱上皮早期病变进行了动态观察。肿瘤的发生,发展经历了从单纯增生,乳头状,结节状增生,良性乳头状瘤,非浸润癌浸润癌这样一个典型的病理过程。诱发的膀胱肿瘤均为移行细胞肿瘤。

    Objective To clarify the influence of E cadherin on the invasive ability of bladder tumor cells. Methods 40 fresh bladder cancer tissues were investigated by matrigel invasion assay and direct sequencing of amplified E cadherin complementary DNA fragments. Results In 32 grade Ⅰ and Ⅱcases,E cadherin mutation was identified in only 2 while it was detected in 4 of 8 grade Ⅲ and Ⅳ cases revealing a positive correlation between E cadherin mutation and the differentiation of tumor cells.E cadherin alteration...

    Objective To clarify the influence of E cadherin on the invasive ability of bladder tumor cells. Methods 40 fresh bladder cancer tissues were investigated by matrigel invasion assay and direct sequencing of amplified E cadherin complementary DNA fragments. Results In 32 grade Ⅰ and Ⅱcases,E cadherin mutation was identified in only 2 while it was detected in 4 of 8 grade Ⅲ and Ⅳ cases revealing a positive correlation between E cadherin mutation and the differentiation of tumor cells.E cadherin alteration was detected in 6 cases of which 4 specimens showed invasive ability on matrigel invasion assay.Only 7 of the 34 cases without E cadherin alteration penetrated the matrigel barrier. Conclusions E cadherin mutation can significantly influence the invasive ability of tumor cells.On the other hand,some tumors without E cadherin alteration may also have invasive ability denoting that other mechanisms should be consi dered .

    目的观察Ecadherin基因突变对膀胱癌侵袭力的影响。方法对40例新鲜膀胱癌标本分别完成体外matrigel穿膜侵袭实验和Ecadherin基因的序列测定。结果病理分级Ⅰ、Ⅱ级者32例中仅有2例出现Ecadherin基因突变,而Ⅲ、Ⅳ级者8例中有4例出现突变,说明Ecadherin变化与肿瘤细胞分化之间有明显的相关性。本组6例标本出现Ecadherin结构改变,其中4例穿膜侵袭实验阳性,而34例未发现Ecadherin基因改变的标本中,只有7例穿膜侵袭实验阳性。结论Ecadherin基因改变对肿瘤细胞的侵袭能力有明显影响。未发现Ecadherin基因突变的标本也可能具有侵袭能力,说明在膀胱肿瘤的侵袭过程中存在其它机制。

    Objective To construct the immunotoxin BDI-1-PEA and study its cytotoxicity against human bladder carcinoma in vitro. Methods The immunotoxin BDI-1-PEA was prepared by conjugating pseudomonas exotoxin A (PEA) with monoclonal anti-bladder cancer antibody BDI-1 by using N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP). Results Study in vitro indicated that BDI-1-PEA showed stronger selective cytotoxicity against human bladder carcinoma cell line E-J than free PEA or the mixture of BDI-1 and PEA. Conclusion...

    Objective To construct the immunotoxin BDI-1-PEA and study its cytotoxicity against human bladder carcinoma in vitro. Methods The immunotoxin BDI-1-PEA was prepared by conjugating pseudomonas exotoxin A (PEA) with monoclonal anti-bladder cancer antibody BDI-1 by using N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP). Results Study in vitro indicated that BDI-1-PEA showed stronger selective cytotoxicity against human bladder carcinoma cell line E-J than free PEA or the mixture of BDI-1 and PEA. Conclusion BDI-1-PEA conjugate is an effective immunotoxin against human bladder carcinoma and is a promising candidate for further clinical study.

    目的 构建新型免疫毒素BDI- 1-PEA ,并进行抗人膀胱肿瘤活性的初步研究测定。方法 应用异型双功能连接剂N -琥珀酰胺酯 3- (2 -吡啶基二硫 )丙酸 (SPDP)将抗人膀胱肿瘤单克隆抗体 (BDI- 1)与铜绿假单胞菌外毒素 (PEA)交联 ,制备出新型免疫毒素BDI- 1-PEA。应用四甲基偶氮唑盐 (MTT)法初步检测其对人膀胱肿瘤细胞系E -J的选择性杀伤活性。结果 BDI- 1-PEA结合物具有高效靶向杀伤膀胱肿瘤细胞的能力 ,优于游离PEA或PEA与BDI- 1的混合物。结论 新型免疫毒素BDI- 1-PEA有较高的选择性抗人膀胱肿瘤细胞的活性 ,有较高的研究和应用价值

     
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