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时间-效应曲线
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  “时间-效应曲线”译为未确定词的双语例句
     The effects of PKC activator PMA (0.5 μmol/L) time-response cures and NF-κB inhibitor PDTC (0- 1 000 μmol/L) concentration-response cures on pulmonary artery rings were observed. The responsiveness of each ring was tested by applying a maximally effective concentration of phenylephrine (10 μmol/L).
     取低氧模型组和常氧组大鼠的去内皮肺动脉环 ,观察PKC激活剂PMA 0 5 μmol/L对肺动脉环的时间 -效应曲线以及NF -κB抑制剂PDTC 0 - 10 0 0 μmol/L时对PMA诱导肺动脉环反应性改变的浓度 -效应曲线。
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     METHODS: Cell proliferation was studied by MTT assay and soft agar cloning test. Different concentrations of pair of hydrogen artemisinin were applied, and IC 50 and the cloning ratio of the drug against the cells were calculated.
     方法 :采用细胞计数法、MTT法、软琼脂克隆形成试验等观察、测定双氢青蒿素对喉癌细胞 (HeP 2 )的细胞增殖率、细胞群体倍增时间、双氢青蒿素对HeP 2细胞生长抑制作用的剂量 -效应曲线、时间 -效应曲线以及对该细胞克隆形成率的影响 . 结果 :①细胞生长曲线显示该细胞增殖活跃 ,生长稳定 ,细胞群体倍增时间为 2 4 7h ;
短句来源
     RESULTS: Pair of hydrogen artemisinin inhibited the proliferation of Hep-2 in a time and dose dependent manner.
     ②双氢青蒿素对Hep 2细胞有明显的生长抑制作用 ,其作用特点呈浓度依赖性 ,其IC50 值为 4 4 6 6 84 μg/L . 时间 -效应曲线显示 :当作用时间在 2 4~ 12 0h时 ,呈剂量依赖性关系及时间依赖性关系 .
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     Methods In male Wistar rats, ATI1 AS-ODN was locally delivered to one kidney through unilateral injection via renal artery followed by electroporation of the injected kidney. FITC-labeled AS-ODN was used to visualize the localization of transferred ODN on frozen section of the transfected kidney.
     方法 采用单侧肾动脉注射+原位电穿孔的方法, 将AT1 AS-ODN导入到Wistar大鼠的一侧肾脏,观察以FITC荧光标记的ODN在肾脏的转移位 置,以AT1放射自显影定量分析的方法观察转移基因的时间-效应曲线
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     The apparent parameters of pharmacodynamics were estimated based on time-effect curves of compound brucine 32.6 mg/kg ip. Results Compound brucine can prolong the incubation period of pain caused by hot-plate in mice obviously.
     ②小鼠腹腔注射32.6mg/kg复方马钱子碱,药前和药后不同时间测定小鼠痛阈,绘制时间-效应曲线
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  相似匹配句对
     TIME DEPENDENT GROUND CHARACTERISTIC CURVES AROUND TUNNEL
     考虑时间效应的围岩特征曲线
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     2. time effect;
     2、时间效应问题;
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     curve
     曲线
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     J Curve Effect of Labor Transfer
     劳动力转移的J曲线效应
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     Time is...
     时间
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  time effect curve
In the falling arm of the test dose time/effect curve, consistent, clear decreases in morphine hyperthermia were seen.
      
Similar effects were noted when the data were analyzed in terms of area under the time/effect curve for hyperthermia.
      


Objective: The effect of zinc on phosphoinositol signal transduction system in rat osteoblasts in vitro was studied. Methods: The osteoblasts were isolated from the rat calvaria, and were subcultured in DMEM medium. Four groups were designed in the study, and they were control, 10μmol/L, 25μmol/L and 50μmol/L Zn 2+ groups respectively. Cellular PKC activity and IP 3 content were measured after treatment of Zn 2+ for a long period or...

Objective: The effect of zinc on phosphoinositol signal transduction system in rat osteoblasts in vitro was studied. Methods: The osteoblasts were isolated from the rat calvaria, and were subcultured in DMEM medium. Four groups were designed in the study, and they were control, 10μmol/L, 25μmol/L and 50μmol/L Zn 2+ groups respectively. Cellular PKC activity and IP 3 content were measured after treatment of Zn 2+ for a long period or a short period. PKC activity was measured according to the level of phosphorylated peptide. IP 3 content was measured according to the methods of 3H myo inositol incorporation and chromatography separation. Results: (1)In long term test cellular IP 3 content and PKC activity in three Zn 2+ groups were significantly elevated as compared with the control group after treatment of Zn 2+ for three days. IP 3 content and PKC activity increased with Zn 2+ levels. (2)In short term test the effect of 25μmol/L Zn 2+ was obvious. Cellular IP 3 content increased significantly just after treatment of 25μmol/L Zn 2+ for 15 minutes, and remained at a high level in two hours. The time response curve kept stable. IP 3 content in 50μmol/L Zn 2+ group was a little lower than that of 25μmol/L Zn 2+ group. IP 3 content in 10μmol/L Zn 2+ group was just a little more than that of control group. PKC activities in 25μmol/L Zn 2+ group and 50μmol/L Zn 2+ group were higher than that of the control group at each time point in 2 hours. The time response curve of PKC was just stable and similar to that of IP 3. Conclusion: Zinc can activate the phosphoinositol signal transduction system in rat osteoblasts in vitro, and elevate IP 3 content and PKC activity. The mechanism includes not only the membrane receptor mediated pathway but also possibly the direct Zn 2+ action.

目的: 研究锌对体外培养大鼠成骨细胞肌醇磷脂信号转导系统的影响。方法: 从大鼠颅骨分离出成骨细胞,于 D M E M 培养基中进行传代培养。实验分为对照组、10μmol/ L、25μmol/ L 及50μmol/ L Zn2 + 剂量组:分别测定了 Zn2 + 对成骨细胞长期或短期作用后蛋白激酶 C( P K C) 活性及三磷酸肌醇( I P3) 含量的变化。根据被磷酸化多肽底物的量测定 P K C 活性,按照3 Hm yo肌醇掺入及层析分离法测定 I P3 含量。结果: (1) 三个不同剂量的 Zn2 + 作用于大鼠成骨细胞3 天后, I P3 含量及 P K C 活性均显著高于对照组;且随着 Zn2 + 剂量的增加, I P3 含量及 P K C 活性有相应增加的趋势;(2) 在短期实验中,25μmol/ L Zn2 + 对成骨细胞的作用比较明显,仅作用15 分钟, I P3 含量即明显提高,且在以后的各个作用时点均明显高于对照组,但时间效应曲线平坦;50μm ol/ L Zn2 + 组 I P3 含量在各个时点略低于25μmol/ L Zn2 +组;10μm ol/ L Z...

目的: 研究锌对体外培养大鼠成骨细胞肌醇磷脂信号转导系统的影响。方法: 从大鼠颅骨分离出成骨细胞,于 D M E M 培养基中进行传代培养。实验分为对照组、10μmol/ L、25μmol/ L 及50μmol/ L Zn2 + 剂量组:分别测定了 Zn2 + 对成骨细胞长期或短期作用后蛋白激酶 C( P K C) 活性及三磷酸肌醇( I P3) 含量的变化。根据被磷酸化多肽底物的量测定 P K C 活性,按照3 Hm yo肌醇掺入及层析分离法测定 I P3 含量。结果: (1) 三个不同剂量的 Zn2 + 作用于大鼠成骨细胞3 天后, I P3 含量及 P K C 活性均显著高于对照组;且随着 Zn2 + 剂量的增加, I P3 含量及 P K C 活性有相应增加的趋势;(2) 在短期实验中,25μmol/ L Zn2 + 对成骨细胞的作用比较明显,仅作用15 分钟, I P3 含量即明显提高,且在以后的各个作用时点均明显高于对照组,但时间效应曲线平坦;50μm ol/ L Zn2 + 组 I P3 含量在各个时点略低于25μmol/ L Zn2 +组;10μm ol/ L Zn2 + 组略高于对照组。25μmol/ L Zn2 + 、50μm ol/ L Zn2 + 组 P K

Objective:To study the time response of fission neutrons induced apoptosis in murine thymocytes with 60 Co γ-rays as the reference radiation and to investigate preliminarily its molecular mechanism. Methods: Apoptosis induction was detected by means of DNA gel electrophoresis, morphologic assay, flow cytometric (FCM) analysis and diphenylamine(DPA) method respectively. p53 and bcl-2 gene expressions were studied by dot hybridization with digoxigenin labeled probes. Results: When mice was exposed to ...

Objective:To study the time response of fission neutrons induced apoptosis in murine thymocytes with 60 Co γ-rays as the reference radiation and to investigate preliminarily its molecular mechanism. Methods: Apoptosis induction was detected by means of DNA gel electrophoresis, morphologic assay, flow cytometric (FCM) analysis and diphenylamine(DPA) method respectively. p53 and bcl-2 gene expressions were studied by dot hybridization with digoxigenin labeled probes. Results: When mice was exposed to 2.5 Gy of fission neutrons, DNA ladders of thymocytes were detected at different time points during 2-24 hours post-irradiation. Thymocytes with typical morphological characteristics of apoptosis were also observed. Time response curves were obtained with methods of morphologic assay, FCM analysis and DPA method. The percentage of thymocytes undergoing apoptosis steeply increased during the first 6 hours post-irradiation,reached the peak levels at 8-10 hours,began to decrease 12 hours later and significantly decreased by 24 hours as compared with the level at 4-12 hours (P<0.05)but was still slightly higher than the normal level. Similar curves were obtained by using three different methods. Time response curve after exposure to 5.0 Gy of γ- irradiation was characterized by an initial slow increase in the number of apoptotic thymocytes during the first 6 hours post-irradiation. In addition, DNA ladders were not detected at 24 hours post-irradiation. After exposure to 2.5 Gy of fission neutrons irradiation, p53 gene expression at 2, 4, 12 and 24 hours post-irradiation were obviously higher than in control (P<0.05 or P<0.01),while bcl-2 gene expression at different time points during 2-24 hours post-irradiation decreased obviously (P<0.01)in comparison with non-irradiated control. Conclusions: Apoptosis of murine thymocytes can be induced in mice exposed to 2.5 Gy of fission neutrons. The rules of time response after fission neutrons irradiation for 2.5 Gy is similar to γ-ray irradiation for 5.0 Gy. However,apoptosis induced by fission neutrons irradiation increases were rapidly and lasts longer than that induced by γ-irradiation. These results indicate that damage to murine immune tissues induced by fission neutrons is more severe and difficult for discovery than that induced by γ-rays. The results of examination of gene expression by dot hybridization show that p53 and bcl-2 genes are involved in the regulation of fission neutrons induced apoptosis in thymocytes. [

目的 :以60 Coγ射线为参比射线 ,研究裂变中子诱导小鼠胸腺细胞凋亡的时间效应 ,并初步探讨其分子机制。方法 :用形态学观察、DNA电泳、流式细胞仪 (FCM )分析及二苯胺 (DPA)法检测细胞凋亡 ;用斑点杂交方法检测 p53与bcl 2的基因表达。 结果 :小鼠经裂变中子 2 .5Gy照射后 2~ 2 4h ,在各时间点上均检测到胸腺细胞DNA梯状条带 ,利用光镜与电镜观察到具有典型凋亡特征的胸腺细胞 ;以DPA法、FCM分析与形态观察计数测定的结果 ,绘制时间效应曲线 ,发现胸腺细胞凋亡比例随着照射时间的延长而增加 ,在 6h前上升较快 ,8~ 10h达到峰值 ,12h后开始下降 ,2 4h较 4~ 12h明显降低 (P <0 .0 5) ,但略高于正常水平。γ射线 5.0Gy照射后 ,胸腺细胞凋亡比例随时间的变化规律与之相似 ,但在 6h之前增加较缓 ;此外 ,在照后 2 4h检测不到DNA梯状条带。裂变中子 2 .5Gy照射后 ,小鼠胸腺细胞 p53基因表达水平在 2、4、12、2 4h均比未照射组有显著增加 (P <0 .0 5或P...

目的 :以60 Coγ射线为参比射线 ,研究裂变中子诱导小鼠胸腺细胞凋亡的时间效应 ,并初步探讨其分子机制。方法 :用形态学观察、DNA电泳、流式细胞仪 (FCM )分析及二苯胺 (DPA)法检测细胞凋亡 ;用斑点杂交方法检测 p53与bcl 2的基因表达。 结果 :小鼠经裂变中子 2 .5Gy照射后 2~ 2 4h ,在各时间点上均检测到胸腺细胞DNA梯状条带 ,利用光镜与电镜观察到具有典型凋亡特征的胸腺细胞 ;以DPA法、FCM分析与形态观察计数测定的结果 ,绘制时间效应曲线 ,发现胸腺细胞凋亡比例随着照射时间的延长而增加 ,在 6h前上升较快 ,8~ 10h达到峰值 ,12h后开始下降 ,2 4h较 4~ 12h明显降低 (P <0 .0 5) ,但略高于正常水平。γ射线 5.0Gy照射后 ,胸腺细胞凋亡比例随时间的变化规律与之相似 ,但在 6h之前增加较缓 ;此外 ,在照后 2 4h检测不到DNA梯状条带。裂变中子 2 .5Gy照射后 ,小鼠胸腺细胞 p53基因表达水平在 2、4、12、2 4h均比未照射组有显著增加 (P <0 .0 5或P <0 .0 1) ;bcl 2基因表达水平均比未照射组明显降低 (P <0 .0 1)。结论 :裂变中子 2 .5Gy照射小鼠可诱导其胸腺细胞凋亡 ,且与γ射线 5.0Gy照射有类似的时相性 ,但裂变中子诱导的胸腺细胞凋亡比γ射线增加快、持续时间长 ,表明裂变中子对小鼠免疫系统损伤较

Objective To elucidate whether the mechanism of relieving hypoxic hypertension by ginkgo biloba involves attenuation of the function of protein kinase C(PKC) signal channel Methods 1 Wistar rats were randomly divided into control(C), hypoxic(H) and ginkgo biloba treatment(GB+H)(200 mg·kg 1 ·d 1 , orally) groups ( n =7) Each rat was first measured mean pulmonary arterial pressure (mPAP), mean systemic arterial pressure (mSAP) and the ratio of the weight of right ventricle to that of left...

Objective To elucidate whether the mechanism of relieving hypoxic hypertension by ginkgo biloba involves attenuation of the function of protein kinase C(PKC) signal channel Methods 1 Wistar rats were randomly divided into control(C), hypoxic(H) and ginkgo biloba treatment(GB+H)(200 mg·kg 1 ·d 1 , orally) groups ( n =7) Each rat was first measured mean pulmonary arterial pressure (mPAP), mean systemic arterial pressure (mSAP) and the ratio of the weight of right ventricle to that of left ventricle plus septum [RV/(LV+S)], then two main pulmonary artery rings were isolated to exposed to PDBu(a specific activator of PKC) to observe the time response curve and the dose response curve in response to 500 nmol/L PDBu and 10~11 000 nmol/L PDBu respectively to evaluate the function of protein kinase C signal channel 2 Intrapulmonary artery rings of human(IARH) from pneumolobectomy were randomly divided into PDBu, RO318220 (inhibitor of PKC)+PDBu and ginkgolide B(BN52021)+PDBu groups( n =6), the IARH of three groups were exposed to 1~25 nmol/L PDBu to achieve dose response curves respectively Results (1) mPAP, RV/(LV+S) of the H group were greater than those of C and GB+H groups respectively ( P <0 05) mPAP of GB+H group was greater than that of C group ( P <0 05) In PA experiments, the function of protein kinase C of H group was higher than those of C and GB+H groups respectively( P <0 05) (2) In IARH experiments, the function of protein kinase C of PDBu group was higher than those of RO318220+PDBu and BN52021+PDBu groups respectively( P <0 05) Conclusions Ginkgo biloba can reduce chronic hypoxic pulmonary hypertension and relieve the hypertrophy of right ventricle, which is partly related to attenuation of the function of PKC signal channel.

目的 探讨银杏叶制剂对大鼠缺氧性肺动脉高压的影响及作用机制与蛋白激酶C(PKC)的关系。方法  (1)Wistar大鼠随机分为正常对照 (C)组、缺氧 (H)组及银杏叶治疗 (GB +H)组(2 0 0mg·kg 1·d 1,灌胃 ) ,每组 7只 ,测其平均体、肺循环动脉压 (mSAP、mPAP)及右心室重 /(左心室重 +室间隔重 ) [RV/(LV +S) ]后 ,再取动物左、右肺外肺动脉 (PA)干 ,观察对 5 0 0nmol/LPKC激动剂phorbol12 ,13 dibutyrate (PDBu)的时间 效应曲线及对 10~ 110 0 0nmol/LPDBu的浓度 效应曲线 ,以衡量PKC的功能状态。 (2 )将 18例肺叶切除患者的肺内肺动脉随机分为PDBu组、PKC抑制剂RO3182 2 0 +PDBu组及银杏苦内酯B(BN5 2 0 2 1) +PDBu组 ,每组 6例 ,作对 1~ 2 5nmol/LPDBu的浓度 效应曲线 ,以衡量PKC的功能状态。结果  (1)动物实验 :H组的mPAP、RV/(LV +S)均分别高于C组及G...

目的 探讨银杏叶制剂对大鼠缺氧性肺动脉高压的影响及作用机制与蛋白激酶C(PKC)的关系。方法  (1)Wistar大鼠随机分为正常对照 (C)组、缺氧 (H)组及银杏叶治疗 (GB +H)组(2 0 0mg·kg 1·d 1,灌胃 ) ,每组 7只 ,测其平均体、肺循环动脉压 (mSAP、mPAP)及右心室重 /(左心室重 +室间隔重 ) [RV/(LV +S) ]后 ,再取动物左、右肺外肺动脉 (PA)干 ,观察对 5 0 0nmol/LPKC激动剂phorbol12 ,13 dibutyrate (PDBu)的时间 效应曲线及对 10~ 110 0 0nmol/LPDBu的浓度 效应曲线 ,以衡量PKC的功能状态。 (2 )将 18例肺叶切除患者的肺内肺动脉随机分为PDBu组、PKC抑制剂RO3182 2 0 +PDBu组及银杏苦内酯B(BN5 2 0 2 1) +PDBu组 ,每组 6例 ,作对 1~ 2 5nmol/LPDBu的浓度 效应曲线 ,以衡量PKC的功能状态。结果  (1)动物实验 :H组的mPAP、RV/(LV +S)均分别高于C组及GB +H组 (P均 <0 0 5 ) ,GB +H组的mPAP仍高于C组 (P <0 0 5 )。在离体PA水平 ,H组的PKC功能状态均分别显著高于C组及GB +H组 (P均 <0 0 5 )。 (2 )人体标本实验 :在离体人肺内PA水平 ,PDBu组的PKC功能状态均分别显著高于RO3182 2 0 +PDBu组及BN5 2 0 2 1+PDBu组 (P均 <0 0 5 )。结论 银杏叶制剂有降低慢性缺氧大鼠肺动脉高压、减轻右心室肥厚之?

 
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