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  schistosoma
    Studies on Antigenic Epitope and Cloning of the Variable Region of Anti-idiotypic Monoclonal Antibody NP30 of Schistosoma Japonicum
    日本血吸虫单克隆抗独特型抗体NP30可变区基因克隆及其抗原模拟表位的研究
短句来源
    Screening and Identification of the Specific IgE Antibody Related Antigen and Mimic Epitopes of Schistosoma Japonicum (Chinese Mainland Strain)
    日本血吸虫(中国大陆株)特异性IgE抗体相关抗原和表位的筛选与鉴定
短句来源
    Schistosoma Japonicum: Cloning of Novel Genes and Study on the Construction and Protection of DNA Vaccines
    日本血吸虫新基因克隆及DNA疫苗的构建和保护性研究
短句来源
    STUDIES ON ARGINASE OF SCHISTOSOMA JAPONICUM
    日本血吸虫精氨酸酶的研究
短句来源
    STUDIES ON THE MICROSOMAL ANTIGENS OF SCHISTOSOMA JAPONICUM Ⅱ. EXTRACTION,FRACTIONATION AND CHEMICAL AND IMMUNOLOGICAL PROPERTIES OF MICROSOMAL ANTIGENS OF ADULT WORM
    日本血吸虫微粒体抗原的研究——Ⅱ.成虫微粒体抗原的提取、分离及其化学和免疫学特性
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  “日本”译为未确定词的双语例句
    The Value of Haemagglutination Reaction in the Diagnosis of Schistosomiasis Japonica
    赤血球凝集反应对日本血吸虫病的诊断价值
短句来源
    Studies on the Tegumentai Membrane Proteins from Adult Schistose ma Japonicum Ⅱ.Analysis of Biochemical and Immuncactive Characterization
    日本血吸虫表皮膜蛋白的研究 Ⅱ.生化及免疫活性分析
短句来源
    STUDY ON PHENOLASE CONTENTS OF S. JAPONICUM
    日本血吸虫酚酶含量的研究
短句来源
    Purification and Analysis of the Circulating Antigens of Schistosomiasis Japonica in Rabbits
    感染日本血吸虫病兔循环抗原的提纯与分析
短句来源
    A PRELIMINARY STUDY ON PROTECTIVE EFFECTS OF CYCLOSPORIN A AGAINST MOUSE SCHISTOSOMIASIS JAPONICA
    环孢菌素A对小鼠日本血吸虫病保护作用的初步研究
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  schistosoma
Heterologous expression of Schistosoma japanicum signal protein 14-3-3 in Pichia pastoris and the subsequent immune response in
      
Schistosomiasis japonica, a zoonosis caused by Schistosoma japonicum, is endemic to the Philippines and China.
      
SDS-PAGE and Western-blot analyses showed that the recombinant protein was about 32 kD and could be recognized by the polyclonal antisera from rabbits immunized with Schistosoma japonicum adult worm antigen.
      
Immunization of mice with cells from juvenile worms of Schistosoma japonicum provides immunoprotection against schistosomiasis
      
Schistosoma japonicum: The design and experimental evaluation of a multivalent DNA vaccine
      
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(1) In 12 apparently healthy monkeys, the average respiratory rate was 46/minute, heart rate 227/minute, systolic/diastolic pressures 155/123 mm Hg, rectal temperature 39.0℃, erythrocytes 5.3 millionscu mm, leukocytes 15700 cu mm, among which lymphocytes 50.8%, neutrophils 45.0%, monocytes 2.0%, eosinophils 1.6%, and basophils 0.6%. (2) Sb-11 (H_2O_3Sb SCH_2COONa) is a pentavalent antimonial salt of stibonic acid. Intravenous injections at the daily dosage of 10 mg/kg in monkeys for 3 or 6 weeks produced no...

(1) In 12 apparently healthy monkeys, the average respiratory rate was 46/minute, heart rate 227/minute, systolic/diastolic pressures 155/123 mm Hg, rectal temperature 39.0℃, erythrocytes 5.3 millionscu mm, leukocytes 15700 cu mm, among which lymphocytes 50.8%, neutrophils 45.0%, monocytes 2.0%, eosinophils 1.6%, and basophils 0.6%. (2) Sb-11 (H_2O_3Sb SCH_2COONa) is a pentavalent antimonial salt of stibonic acid. Intravenous injections at the daily dosage of 10 mg/kg in monkeys for 3 or 6 weeks produced no cough, nausea, vomiting, anorexia or other reactions. Likewise, Sb-11 had no significant influence on the respiration, blood pressure, EXG, temperature, and the blood cell counts. (3) Five monkeys were each infected with 300 cercariae of Schistosoma japonicum. Beginning on the 43rd day after the infection, Sb-11 was given intravenously on 3 monkeys at the dosage of 10 mg/kg/day for 3 weeks. The remaining 2 monkeys served as control. After a holding period of another 4 weeks, the monkeys were autopsied. The numbers of the helminths remained in the 3 monkeys of the medicated group were 0, 1 and 13 respectively, with the schistosomes all degenerated, while those of the control group were 81 and 138 respectively. So the therapeutic effect of Sb-11 was vory remarkable. (4) The toxicity of Sb-11 was rather low. Drug tolerance to Sb-11 developed quickly in monkeys; which showed no toxic manifestations after a course as long as 6 weeks. Hence Sb-11 is recommended to be tried clinically on those patients who cannot receive intensive treatment of tartar emetic.

(一) 12只正常猴子平均呼吸頻率为46次/分,心跳为227次/分,收縮壓/舒張壓为155/12s毫米汞柱,體溫为39.0℃。平均紅血球5.3百萬/立方毫米,白血球15.7千/立方毫米,其中淋巴球50.8%,嗜中性45.0%,單核球2.0%,嗜酸性1.6%及嗜鹼性0.6%。 (二) Sb-11(H_2O_3Sb-SCH_2COONa)是5價之(月弟)酸鹽。猴子靜脈每天10毫克/千克,共3週或6週,無咳嗽、噁心嘔吐及食量減少等毒性反應,且對呼吸,血壓、心電圖、體溫及血球數等也無顯著影響。 (三) 5猴各感染日本血吸蟲尾蚴300條,其中2猴不给藥作對照,3猴自感染後第43天開始治療,劑量10毫克/千克/天,療程3週,停藥4週後解剖。對照组2猴各餘存蟲81與138條;治療組8猴分別餘存蟲0,1與13條,蟲體萎縮,所以療效非常顯著。 (四) Sb-11毒性低,對猴子能產生耐藥性,療程延長至6週亦無毒性表現。所以我們建議,臨床上吐酒石短程療法禁忌的病人,可試用Sb-11。

Adult worms of Schistosoma japonicum, collected from guinea pigs infected 31-54 days previously with 800 to 1,000 cercariae, were homogenized and the homogenate was incubated with 0.1M L-arginine (pH 9.0) at 37℃ for exactly 10 minutes. The urea thus formed was determined by the xanthydrol method and the arginase activity was expressed in micromoles of urea produced per mg. nitrogen of homogenate per hour. The average values of enzymatic activity for male, female and paired worms were 58.0±3.6, 67.2±18.3, and...

Adult worms of Schistosoma japonicum, collected from guinea pigs infected 31-54 days previously with 800 to 1,000 cercariae, were homogenized and the homogenate was incubated with 0.1M L-arginine (pH 9.0) at 37℃ for exactly 10 minutes. The urea thus formed was determined by the xanthydrol method and the arginase activity was expressed in micromoles of urea produced per mg. nitrogen of homogenate per hour. The average values of enzymatic activity for male, female and paired worms were 58.0±3.6, 67.2±18.3, and 55.6±10.7 respectively.The pH optimum for the enzyme was 9.0 and the maximal arginase activity was attained with the substrate concentration of 0.09 M.When the homogenate was pretreated with 10~(-3)M MnSO_4 or CoCl_2 for 30 minutes at 37℃, the enzymatic activity was increased 9.6 or 3.9 times respectively.Lysine, leucine as well as cucurbitine could inhibit this enzyme. F-30066, a new schistosomicide, also showed an inhibitory effect, which was increased considerably if the aqueous solution f F-30066 had been previously exposed to light. Such a solution of 2×10~(-5)M F-30066 caused 40% inhibition. In contrast, 10~(-4)M tartar emetic did not show any effect.The average urea content of Schistosoma japonicum was 1.4 microgram per mg. of nitrogen. Using 50-250 paired worms, no urease could be detected by the usual method.

从人工感染的豚鼠中取得日本血吸虫,制成匀浆后在37℃与pH9.0,0.1M的L-精氨酸作用10分钟,用呫吨氫醇法测定生成的脲量,以求得精氨酸酶的活力,結果用微克分子脲/毫克氮/小时表示。虫龄31—54天的各批血吸虫間酶活力无显著差別,平均值雄虫为58.0±3.6,雌虫为67.2±18.3,合抱虫为55.6±10.7。血吸虫精氨酸酶的最适pH为9.0,但在pH8.7—9.5之間測定的結果差別不大。底物L-精氨酸的最后濃度为0.09M时,酶活力已达最高值;濃度再升高直至O.3M/时,活力維持在同一水平。錳离子和鈷离子能激活血吸虫的精氨酸酶,假使先将这两种离子与匀浆預温30分钟,可使激活作用明显增强。賴氨酸、白氨酸和南瓜子氨酸对血吸虫的精氨酸酶均有抑制作用。治疗血吸虫病新药F-30066对此酶的抑制强度因药物的水溶液曾否見光而异,光照过的F-30066溶液作用較强,在2×10~(-5)M的濃度下可抑制40%。酒石酸銻鉀在10~(-4)M/时对酶活力无影响。血吸虫体內的脲含量平均为1.4微克/毫克氮,用一般的方法于50—250对血吸虫中未能測出有脲酶的存在。

320 sides of origin of the obturator artery and the blood vessels related to the fe-moral ring of Chinese adults were studied. There were 309 instances with a single ob-turator artery (254 arose from the internal iliac artery and 55 from the external iliacartery) and 11 cases with double obturator arteries.The internal iliac origin of the obturator artery bore no relation to the branchingtypes of internal iliac artery.The anomalous obturator artery which originated from the external iliac artery ap-peared in...

320 sides of origin of the obturator artery and the blood vessels related to the fe-moral ring of Chinese adults were studied. There were 309 instances with a single ob-turator artery (254 arose from the internal iliac artery and 55 from the external iliacartery) and 11 cases with double obturator arteries.The internal iliac origin of the obturator artery bore no relation to the branchingtypes of internal iliac artery.The anomalous obturator artery which originated from the external iliac artery ap-peared in 20% of the total specimens. This frequency corresponds with that of theJapanese, but lower than that of the Europeans and Americans. Sex and side failed toshow any difference.The courses of the anomalous obturator arteries and their relation to the femoralring were analyzed. The artery which passed through the medial side of the femoral ring and behind the lacunare ligament, is of clinical importance and was found in 5% of the specimens observed. The percentage is higher than that reported in the literature.Besides, there were comparatively larger veins which ran medially to the femoral ring and opened into the external iliac vein (found in 42.5%).

观察了320侧中国成年人闭孔动脉的起源和股环与邻近血管的比邻关系。每侧有一支闭孔动脉的共309例,其中起源于髂内动脉系的254例,起源于髂外动脉系的55例。每侧有两支闭孔动脉的共11例,两动脉均起源于髂内动脉系的二例,两动脉分别起源于髂内动脉系和髂外动脉系的九例。闭孔动脉在髂内动脉系的起源点比较分散,与髂内动脉的分支类型没有什么关系。起源于髂外动脉系的异常闭孔动脉,按侧别计,其出现率为20%;按尸体计,其出现率为33.13%。中国人的异常闭孔动脉的出现率与日本人接近,而低于欧美人。异常闭孔动脉的出现率在左、右侧之间和男、女性之间均无显著差异。分析了异常闭孔动脉的行程及其与股环的位置关系,其中具有临床意义的是闭孔动脉行经股环的内侧、紧贴陷窝韧带的后方下行,出现率占总数的5%,较其他作者所报导的出现率高,值得重视。此外,在42.5%的标本中,有较大的静脉行经股环内侧汇入髂外静脉。

 
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