1. Association of Polymorphisms of TNF-α and VDR Genes and HBV Genotype with Outcomes of Hepatitis B Virus Infection in Han Population of North China 2. Genetic Polymorphisms of TNF-α, VDR and elf-2α Genes and Response to Interferon Therapy in Patients with Chronic Hepatitis B: A Pilot Sduty
The serum levels of MDA after the treatment with IFN α-2b were significantly lower than the pretreatment levels (P<0.05),which even returned to the normal concentration (P>0.05) in the effective group.
After injection with DC vaccines, IFN-γ production in the treatment group was significantly increased as compared with that in the control group (P>amp;lt;0.01), and IL-4 production was decreased as compared with that in the control group (P>amp;lt;0.05).
Study of recombinant human IFN-α-2b bacilli calmette-guerin activated killer cells and against bladder cancer cell in vitro
Recombinant IFN-α-2b-BCG, wild-type BCG (wBCG), wild-type BCG and IFN-α-2b were coincubated with PBMCs respectively in vitro, and the proliferation of PBMC was detected with MTT in different time.
High CG dose (100 IU/ml) proved to significantly decrease IFNψ level in the T cell culture supernatant, although this effect was not observed at the background of steroid hormones.
In contrast, progesterone (100 ng/ml) increased IFNψ production by activated T lymphocytes but proved inefficient in a physiological combination with CG and estradiol.
Interleukin-2 mediates the peripheral analgesia of interferon alpha
Two patients were treated with interferon alpha and showed a good response.
Similarly, a proportion of patients treated with interferon alpha develop antibodies, which inhibit its therapeutic effects.
Trials with both interferon alpha and gamma proved unsuccessful, as did treatment with oral myelin, cladribine, sulfasalazine and inhibitors of tumour necrosis factor.
Acid-labile interferon alpha was detected in the serum of two patients with AIDS and in three out of nine patients with lymphadenopathy, but not in the sera of healthy homosexual or heterosexual controls.