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乳头形式
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     On form
     “形式”论
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     From the "Methodology" to the "Form"
     从“方法”到“形式
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     Adenoma of the Nipple Duct
     乳头管腺瘤
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     Treatment of crater nipple
     乳头内陷的治疗
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     The patterns of infiltration was categorized-into intraductal, stromal and intraductal plus stro-mal.
     乳头浸润方式分3种:导管浸润、间质浸润和混合形式浸润.
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Objective To investigate the morphologic features, differential diagnosis,prognosis and histogenesis of papillary renal cell carcinoma(PRCC). Methods Tumors composed of at least 50% papillae and >1 cm in diameter were included in this study. Light microscopic observation,immunohistochemical assay of EMA, CK7, CD10, Vim, 34 β E12 by tissue chip were performed. Results Among 516 cases of renal epithelial tumors 33 cases of PRCC were detected. Grossly, hemorrhage, necrosis and multifocality were commonly seen....

Objective To investigate the morphologic features, differential diagnosis,prognosis and histogenesis of papillary renal cell carcinoma(PRCC). Methods Tumors composed of at least 50% papillae and >1 cm in diameter were included in this study. Light microscopic observation,immunohistochemical assay of EMA, CK7, CD10, Vim, 34 β E12 by tissue chip were performed. Results Among 516 cases of renal epithelial tumors 33 cases of PRCC were detected. Grossly, hemorrhage, necrosis and multifocality were commonly seen. Besides typical papillae, inconspicuous papillary patterns, such as trabecular, tubular,micronodular and pseudostratified patterns could be seen. Foam cells and psammoma bodies in stroma, and hemosiderin in tumor cells were characteristic. Tumors were of two major types: basophilic type (n=10), with small cuboid cell and pale cytoplasm(n=10), 9 of them were low in Fuhrman grading; eosinophilic type (n=22) with large columnar cells, rich in eosinophilic cytoplasm, 19 of them were high in Fuhrman grading. The remaining case was of clear cell type. The basophilic tumors were all positive for distal tubule marker EMA /CK7, none for proximal tubule marker CD10, 7 tumors positive for Vim. Eosinophilic tumors were positive for EMA/CK7 (9/22),CD10(10/22) and Vim(6/22). All the tumors studied were negative for 34 β E12. Follow up data were available for 24 cases (mean 37months) with 3 year survival rate of 64.3%, 5 year survival rate of 50%. Conclusion PRCC was a distinct malignant entity with unique pathological features. The prognosis of PRCC was worse than that of chromophobe renal cell carcinoma.

目的 观察乳头状肾细胞癌 (PRCC)的形态特点 ,并对其诊断和鉴别诊断要点、预后及组织发生进行探讨。方法 对 33例直径 >1.0cm、乳头结构占 5 0 %以上的PRCC进行研究。每一例均采用光镜观察 ,利用组织芯片行免疫组化染色 ,检测EMA、CK7、CD10、Vim和 34βE12 ,并进行随访观察。结果  5 16例肾上皮性肿瘤中检出PRCC 33例 (6 .4 % )。镜检可见典型的乳头及梁状、管状、微小结、假复层等不明显的乳头形式 ;间质内的泡沫细胞、沙砾体及肿瘤细胞吞噬含铁血黄素亦是其独特之处。 33例中 ,嗜碱型 10例 ,细胞呈立方形 ,胞浆少 ,淡染 ,Fuhrman分级 9例为低级别 ;嗜酸型 2 2例 ,细胞呈高柱状 ,胞浆丰富 ,嗜酸性 ,Fuhrman分级 19例为高级别 ;余 1例为透明细胞型。 10例嗜碱型仅远曲小管标志EMA或CK7为 (+) ,近曲小管标志CD10均为 (- ) ,7例Vim为 (+) ;2 2例嗜酸型中 ,9例EMA或CK7为 (+) ,10例CD10为 (+) ,6例Vim为 (+) ;33例 34βE12均为 (- )。2 4例获随访 ,...

目的 观察乳头状肾细胞癌 (PRCC)的形态特点 ,并对其诊断和鉴别诊断要点、预后及组织发生进行探讨。方法 对 33例直径 >1.0cm、乳头结构占 5 0 %以上的PRCC进行研究。每一例均采用光镜观察 ,利用组织芯片行免疫组化染色 ,检测EMA、CK7、CD10、Vim和 34βE12 ,并进行随访观察。结果  5 16例肾上皮性肿瘤中检出PRCC 33例 (6 .4 % )。镜检可见典型的乳头及梁状、管状、微小结、假复层等不明显的乳头形式 ;间质内的泡沫细胞、沙砾体及肿瘤细胞吞噬含铁血黄素亦是其独特之处。 33例中 ,嗜碱型 10例 ,细胞呈立方形 ,胞浆少 ,淡染 ,Fuhrman分级 9例为低级别 ;嗜酸型 2 2例 ,细胞呈高柱状 ,胞浆丰富 ,嗜酸性 ,Fuhrman分级 19例为高级别 ;余 1例为透明细胞型。 10例嗜碱型仅远曲小管标志EMA或CK7为 (+) ,近曲小管标志CD10均为 (- ) ,7例Vim为 (+) ;2 2例嗜酸型中 ,9例EMA或CK7为 (+) ,10例CD10为 (+) ,6例Vim为 (+) ;33例 34βE12均为 (- )。2 4例获随访 ,3年生存率 6 4 .3% (9/ 14 ) ,5年生存率 5 0 .0 % (7/ 14 )。结论 乳头状肾细胞癌为独立类型的恶性肿瘤 ,具有独特的病理形态特点 ,其临床预后较嫌色细胞癌差。

 
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