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These proteins may be involved in cardiovascular injury, and could play an important role in the treatment of coronary heart disease.
      
Evaluation of the effect of myocardial perfusion after percutaneous coronary intervention in coronary artery disease by using in
      
Detection of abnormal myocardial perfusion is crucial to the prognosis of patients with coronary artery disease (CAD) after they have undergone percutaneous coronary intervention (PCI).
      
No difference was found in CTFC between the coronary artery stenosis group and the normal group.
      
Thus, the IC-MCE method is of great value to coronary artery disease (CAD) patients undergoing PCI, especially for those with acute myocardial infarction (AMI).
      
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Evaluation of the effect of myocardial perfusion after percutaneous coronary intervention in coronary artery disease by using in
      
Detection of abnormal myocardial perfusion is crucial to the prognosis of patients with coronary artery disease (CAD) after they have undergone percutaneous coronary intervention (PCI).
      
No difference was found in CTFC between the coronary artery stenosis group and the normal group.
      
Thus, the IC-MCE method is of great value to coronary artery disease (CAD) patients undergoing PCI, especially for those with acute myocardial infarction (AMI).
      
In addition, slight atherosclerosis of the coronary artery and intimal thickening of the sino-atrial node were observed.
      
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In 7 anaesthetized open-chest dogs,an intravenous injection of changrolin7 mg/kg brought forth a marked lowering of blood pressure and the work doneby left ventricle.The decreasing of coronary blood flow and aortic blood flowwere not significant,while the coronary vascular resistance tended to decline.During the period of lowering of the work done by left ventricle,the myocardialutilization of oxygen,lactic acid and pyruvic acid were not obviously affected.Two-stage left anterior coronary ligation was performed...

In 7 anaesthetized open-chest dogs,an intravenous injection of changrolin7 mg/kg brought forth a marked lowering of blood pressure and the work doneby left ventricle.The decreasing of coronary blood flow and aortic blood flowwere not significant,while the coronary vascular resistance tended to decline.During the period of lowering of the work done by left ventricle,the myocardialutilization of oxygen,lactic acid and pyruvic acid were not obviously affected.Two-stage left anterior coronary ligation was performed in 6 anaesthetizeddogs.After 24 hours,severe ventricular arrhythmias were recorded under consciousstate.An intravenous bolus of changrolin 5 mg/kg produced a remarkable anti-arrhythmic effect lasting about half an hour.The P-R interval,QRS complexand Q-T interval of sinus rhythm were not much altered.Since changrolin is very effective in controlling the ventricular arrhythmiaafter acute myocardial infarction in dogs,it deserves clinical trials.

麻醉开胸狗7只,静注常咯啉7mg/kg,血压和左心室作功显著减低,冠脉血流量和主动脉血流量减少不显著,而冠脉阻力有减低趋势。在左心室作功减低时,心肌对氧、乳酸和丙酮酸的利用无明显影响。麻醉开胸结扎左冠状动脉前降支24小时后的清醒狗6只,静脉推注常咯啉5mg/kg对心肌梗塞后室性心律失常有明显的治疗效果,有效时间约半小时左右。对窦性心律的 P-R,QRS 和 Q-T 间期无明显改变。因常咯啉能有效控制狗急性心肌梗塞后的室性心律失常,值得临床试用。

The Correlative analysis of STI and 5-year motality in 38 patients suffering from coronary heart disease has been made. 8 of them died of myocardial reinfarction, cardiogenic shock and arythmia between 1974 and 1979. Cumulative morality was higher in patients with PEP/LVET≥0.4 (equal to Mean±2×SD of normals) than that of PEP/LVET<0.4 (P 0.5). There was no significant difference between other indices of STI and medical data. It is concluded that PEP/LVET can be used as an index for predicting the prognosis in...

The Correlative analysis of STI and 5-year motality in 38 patients suffering from coronary heart disease has been made. 8 of them died of myocardial reinfarction, cardiogenic shock and arythmia between 1974 and 1979. Cumulative morality was higher in patients with PEP/LVET≥0.4 (equal to Mean±2×SD of normals) than that of PEP/LVET<0.4 (P 0.5). There was no significant difference between other indices of STI and medical data. It is concluded that PEP/LVET can be used as an index for predicting the prognosis in CHD.

回顾性分析了38名冠心病人五年(1974—1979)病死率与左室收缩间期(STI)的相关。五年内共有8人死亡,其死亡原因经医院或医生诊断为心肌再梗塞,休克或心律失常、猝死。 以STI值超过正常人“均值士2×标准差”为界限,对比了生存与死亡的分布。超过此界限者,五年的累计病死率比低于此界限的要高的多(P<0.05).其中以PEP/LVET一项在区别生存与死亡上最为显著。冠心病人左心功能指标在一定程度上反映了冠脉病变和心肌缺血的严重程度,因而与预后有关。

Alteration of refractoriness during acute myocardial ischemia was examinedin open-chest anaesthetised rabbits.Monophasic action potential(MAP)recor-dings obtained by suction electrode were used for defining the time intervals ofthe functional refractory periods(FRP)as well as the postrepolarization refrac-toriness(PRR)which was longer than the duration of 90% repolarization of theMAP(MAPD_(90)).Following occlusion of the left ventricular branch of the co-ronary artery in 14 rabbits,it was demonstrated that there...

Alteration of refractoriness during acute myocardial ischemia was examinedin open-chest anaesthetised rabbits.Monophasic action potential(MAP)recor-dings obtained by suction electrode were used for defining the time intervals ofthe functional refractory periods(FRP)as well as the postrepolarization refrac-toriness(PRR)which was longer than the duration of 90% repolarization of theMAP(MAPD_(90)).Following occlusion of the left ventricular branch of the co-ronary artery in 14 rabbits,it was demonstrated that there were two divergentchanges in FRP,a prolongatioa beyond MAPD_(90) in the central ischemic zoneand a shortening as usually found in the peripheral ischemic zone.By using rab-bit hearts perfused with arterial blood from their own common carotid artery,thePRR was found in the central ischemic zone when the perfusing blood was com-pletely occluded.When 50% occlusion was performed,only FRP shortened to someextent.When FRP in the central ischemic zone,the peripheral ischemic zoneand the non-ischemic zone was examined simultaneously,the results showed thatthe dispersion of refractoriness after occlusion of the coronary artery was apparent-ly correlated with occurrences of the PRR at the same time and this dispersionof refractoriness is the major cause resulting in re-entry arrhythmia.

本实验观察了开胸麻醉家兔急性心肌缺血时的不应期改变。用吸引电极记录的单相动作电位(MAP)确定机能不应期(FRP)及 FRP 超过 MAP 复极90%时程(MAPD_(90))的复极后不应性(PRR)。阻断冠脉左室支以后,缺血区不应期表现出两种完全不同的变化:缺血中心区不应期延长并超过 MAPD_(90),出现 PRR;缺血周边区不应期则通常较对照缩短。利用自体颈总动脉的动脉血进行灌流的兔心实验表明,当100%阻断灌流血液时,缺血中心区出现PRR,但是当50%阻断时,同一部位心肌的不应期却表现为缩短。上述结果提示:PRR 是在严重心肌缺血情况下出现的。同一时刻测定缺血中心区、周边区和非缺血区的功能不应期,结果表明,冠脉阻断后不应期离散程度的明显增大是与当时 PRR 的出现密切相关的。因此,PRR 的存在可以认为是造成急性心肌缺血时不应期离散的重要原因,而后者一般认为是异致折返性心律失常的重要因素。

 
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