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|  | | 为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法,我们为您准备了出自英文原文的大量英语例句,供您参考。 | |
Design, Synthesis and Growth Inhibition Activity of Bis-Epoxyethyl Derivatives of Stallimycin Modified on the Amidino Moiety
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The effect of the most promising ones have been looked on the counterparts from mammalian sources and difference in the susceptibility towards enzyme activity inhibition were noted.
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Results revealed some definite correlation between the enzyme inhibition with GSH depletion in S.
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In vitro enzyme inhibition studies have identified three inhibitors (14, 16, 23) of the falcipains with one (14) showing dual activity against both falcipain-2 and falcipain-3 and IC50 values of 6.6 and 29.4 μM, respectively.
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Seven compounds caused 50% growth inhibition (GI50) of tumor cells at concentrations of >amp;lt;100 μM while the remaining ten were not cytotoxic.
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In this study, we find that prodigiosin could effectively inhibit the proliferation of human pancreatic cancer cells H8898 in a dose-and-time-dependent manner, with an IC50 of 75μmol according to the results of MTT and cell proliferation assays.
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All these results demonstrate that prodigiosin can obviously inhibit the proliferation of pancreatic cancer cells H8898 by arresting the cell cycle and inducing apoptosis.
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We evaluated a series of 2H-pyridazine-3-one and 6-chloropyridazine analogues via an in vitro spectrophotometric assay for their ability to inhibit rat kidney AR.
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In this study, a series of 2-phenylindole derivatives were evaluated via an in vitro spectrophotometric assay for their ability to inhibit rat kidney AR.
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The other type can inhibit the phytoplankton growth, which is about μmol level or higher.
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These studies may be useful in designing molecules with better cyclooxygenase-2 inhibitory activity.
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PHENYLPYRUVIC ACID DERIVATIVES AS ENZYME INHIBITORS: THERAPEUTIC POTENTIAL ON MACROPHAGE MIGRATION INHIBITORY FACTOR
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The models obtained may be used as useful tools for predicting whether a molecule of pharmacological interest bears structural features likely to possess CETP inhibitory activity prior to synthesis.
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Among a total of 38 glycosyl ureas, 2 showed more than 50% inhibitory effect.
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Among a total of 66 glycosyl ureas/ thioureas and glycopeptidyl ureas, 3 showed more than 50% stimulatory effect whereas 2 showed more than 50% inhibitory effect.
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The dimethylaminoethoxypridines 6 and 7 inhibited the specific bind of (-)-[3H]Nicotine with Ki values of 300 nM and 450 nM, respectively.
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Etiolated wheat coleptiles were inhibited 100 and 40%, respectively, at 10-3 and 10-4 M.
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Molecules 6f, i, and j inhibited only COX-1, and the disubstituted ethoxy derivative (6g) was inactive as a COX inhibitor (≤ 100?μM).
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It demonstrated that all of these curcumin derivatives inhibited the formation of advanced glycation end products (AGE).
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Additionally, (2) also inhibited the proliferation of human erythroleukemia cancer cell line K562 with IC50 value of 49.1 μg/mL.
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