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输尿管梗阻
相关语句
  ureteral obstruction
    Conclusions After ureteral obstruction, CD8+ T lymphocytes infiltrate into the renal interstitium and the expressions of α-sSMA, TGF-β1 mRNA and TJMP-1 mRNA increase, which consequently results in a remarkable increaseing deposition of collagen Ⅰ, Ⅲ, Ⅳ in the renal interstitium. Enalapril possesses inhibitory effects on the above procedure.
    结论输尿管梗阻后CD8+T淋巴细胞浸润肾间质,α-SMA; TGF-β1mRNA、TIMP-1mRNA表达增加,导致梗阻肾间质Ⅰ、Ⅲ、Ⅳ型胶原均明显增加,依那普利对其有一定的抑制作用。
短句来源
    The mechanism of renal interstitial fibrosis after unilateral ureteral obstruction in rats and effects of enalapril on the process
    单侧输尿管梗阻后肾间质纤维化的产生机制及依那普利对其调节作用
短句来源
    Objective To study the mechanism of renal interstitial fibrosis after unilateral ureteral Obstruction and effects of enalapril on the process of the fibrosis.
    目的 研究单侧输尿管梗阻后肾间质纤维化发生机理及血管紧张素转换酶抑制剂依那普利对其的调节作用。
短句来源
    Research advancement of widely-used eight animal models of renal interstitial fibrosis,such as unilateral ureteral obstruction,cyclosporine A nephropathy and chronic aristolochic acid nephropathy,are reviewed in this paper.
    本文对常见的肾间质纤维化动物模型,包括单侧输尿管梗阻、环孢素A肾病、慢性马兜铃酸肾病等8种模型的制作和研究进展作一综述。
短句来源
  unilateral ureteral obstruction
    Objective To study the mechanism of renal interstitial fibrosis after unilateral ureteral Obstruction and effects of enalapril on the process of the fibrosis.
    目的 研究单侧输尿管梗阻后肾间质纤维化发生机理及血管紧张素转换酶抑制剂依那普利对其的调节作用。
短句来源
    Research advancement of widely-used eight animal models of renal interstitial fibrosis,such as unilateral ureteral obstruction,cyclosporine A nephropathy and chronic aristolochic acid nephropathy,are reviewed in this paper.
    本文对常见的肾间质纤维化动物模型,包括单侧输尿管梗阻、环孢素A肾病、慢性马兜铃酸肾病等8种模型的制作和研究进展作一综述。
短句来源
  ureteral obstruction
    Conclusions After ureteral obstruction, CD8+ T lymphocytes infiltrate into the renal interstitium and the expressions of α-sSMA, TGF-β1 mRNA and TJMP-1 mRNA increase, which consequently results in a remarkable increaseing deposition of collagen Ⅰ, Ⅲ, Ⅳ in the renal interstitium. Enalapril possesses inhibitory effects on the above procedure.
    结论输尿管梗阻后CD8+T淋巴细胞浸润肾间质,α-SMA; TGF-β1mRNA、TIMP-1mRNA表达增加,导致梗阻肾间质Ⅰ、Ⅲ、Ⅳ型胶原均明显增加,依那普利对其有一定的抑制作用。
短句来源
    The mechanism of renal interstitial fibrosis after unilateral ureteral obstruction in rats and effects of enalapril on the process
    单侧输尿管梗阻后肾间质纤维化的产生机制及依那普利对其调节作用
短句来源
    Objective To study the mechanism of renal interstitial fibrosis after unilateral ureteral Obstruction and effects of enalapril on the process of the fibrosis.
    目的 研究单侧输尿管梗阻后肾间质纤维化发生机理及血管紧张素转换酶抑制剂依那普利对其的调节作用。
短句来源
    Research advancement of widely-used eight animal models of renal interstitial fibrosis,such as unilateral ureteral obstruction,cyclosporine A nephropathy and chronic aristolochic acid nephropathy,are reviewed in this paper.
    本文对常见的肾间质纤维化动物模型,包括单侧输尿管梗阻、环孢素A肾病、慢性马兜铃酸肾病等8种模型的制作和研究进展作一综述。
短句来源
  “输尿管梗阻”译为未确定词的双语例句
    Urine protein and NAG enzyme of the GM model were significantly higher than the control on the 7th day, however, no significant difference was observed on the 15th day. Urine protein and NAG enzyme of the UUO model were significantly higher than the control on the 7th and 15th day, whereas urine protein of the CsA model was lower (7d %p%<0.05, 15d %p%<0.01).
    庆大霉素模型尿蛋白和NAG酶在 7d时急剧增高 ,而在 15d时NAG酶差异已无显著性 ,单侧输尿管梗阻模型尿蛋白和NAG酶均显著增高 ,CsA模型的尿蛋白则呈下降趋势 ( 7dP <0 .0 5 ,15dP <0 0 1) ;
短句来源
    Methods The model was induced by unilateral ureteral ligation in rats and the rats were sacrificed at postoperative days 3, 7, 14, 28, 56, and 84. Besides routine morphologic examinations, interstitial collagen type Ⅲ and Fas expression was detected by immunohistochemistry staining and apoptotic cells were determined by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling(TUNEL).
    方法 建立大鼠单侧输尿管梗阻模型,分别于模型3 天、7 天、14 天、28 天、56 天和84 天处死大鼠。 除光镜、电镜观察外,免疫组织化学染色检测胶原Ⅲ和Fas 蛋白表达,末端转移酶介导的dUTP缺口末端标记法检测凋亡细胞。
短句来源
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  ureteral obstruction
Effects of mycophenolate mofetil on renal interstitial fibrosis after unilateral ureteral obstruction in rats
      
To investigate the effects of mycophenolate mofetil (MMF) on the process of renal interstitial fibrosis, unilateral ureteral obstruction (UUO) model was established in rats.
      
In order to explore the role of connective tissue growth factor (CTGF) in the pathogenesis of renal tubulointerstitial fibrosis, 48 Wistar rats were randomly divided into sham-operated and unilateral ureteral obstruction (UUO) group.
      
The role of protease activated receptor-2 (PAR-2) in the renal tubulointerstitial lesion induced by unilateral ureteral obstruction (UUO) was explored.
      
Zinc deficiency aggravates tubulointerstitial nephropathy caused by ureteral obstruction
      
更多          
  unilateral ureteral obstruction
Effects of mycophenolate mofetil on renal interstitial fibrosis after unilateral ureteral obstruction in rats
      
To investigate the effects of mycophenolate mofetil (MMF) on the process of renal interstitial fibrosis, unilateral ureteral obstruction (UUO) model was established in rats.
      
In order to explore the role of connective tissue growth factor (CTGF) in the pathogenesis of renal tubulointerstitial fibrosis, 48 Wistar rats were randomly divided into sham-operated and unilateral ureteral obstruction (UUO) group.
      
The role of protease activated receptor-2 (PAR-2) in the renal tubulointerstitial lesion induced by unilateral ureteral obstruction (UUO) was explored.
      
The present study was designed to explore whether zinc (Zn) deficiency affects the development of unilateral ureteral obstruction (UUO)-induced tubulointerstitial nephropathy.
      
更多          
  ureteral obstruction
Effects of mycophenolate mofetil on renal interstitial fibrosis after unilateral ureteral obstruction in rats
      
To investigate the effects of mycophenolate mofetil (MMF) on the process of renal interstitial fibrosis, unilateral ureteral obstruction (UUO) model was established in rats.
      
In order to explore the role of connective tissue growth factor (CTGF) in the pathogenesis of renal tubulointerstitial fibrosis, 48 Wistar rats were randomly divided into sham-operated and unilateral ureteral obstruction (UUO) group.
      
The role of protease activated receptor-2 (PAR-2) in the renal tubulointerstitial lesion induced by unilateral ureteral obstruction (UUO) was explored.
      
Zinc deficiency aggravates tubulointerstitial nephropathy caused by ureteral obstruction
      
更多          


Objective To study the expressions of angiotensin Ⅱ1A receptor (AT1A) both at the mRNA level and the protein level and their modulation by an angiotensin converting enzyme inhibitor, benazepril, in the renal tubulointerstitial injuries induced by unilateral ureteral obstruction (UUO) in rats. Methods Six SD rats (UUO T) were administered benazepril in the drinking water (50mg/L). Additional 6 rats were used as untreated controls (UUO C). Mean arterial Prossure (MAP) was measured at the 10th...

Objective To study the expressions of angiotensin Ⅱ1A receptor (AT1A) both at the mRNA level and the protein level and their modulation by an angiotensin converting enzyme inhibitor, benazepril, in the renal tubulointerstitial injuries induced by unilateral ureteral obstruction (UUO) in rats. Methods Six SD rats (UUO T) were administered benazepril in the drinking water (50mg/L). Additional 6 rats were used as untreated controls (UUO C). Mean arterial Prossure (MAP) was measured at the 10th day after UUO, and then all animals were sacrificed. The expressions of AT1A were examined both at the mRNA level by in situ hybridization using a subtype specific probe and at the protein level by an immunohistochemistry methods using AT1 receptor antibody in normal rat kidneys and the obstructed rat kidneys. Results MAP was 14.2±0.6kPa in the UUO T and 16.6±0.7 kPa in the UUO C ( P < 0.05). Benazepril slowed the tubulointersititial fibrosis (TIF) and reduced the expression of AT1A in the renal tubular epithelial cells, the interstitial areas, and the walls of renal arteriole in the UUO T group. Conclusion The increased expressions of AT1A were found in the acute renal tubulointerstitial pathogenesis induced by UUO. Benazepril may retard the progression of TIF and decrease the expression of AT1A in the obstructed kidneys. We conclude that the effects of Ang Ⅱ on the obstructed kidneys may be due to its binding with AT1A.

目的从蛋白质和基因水平探讨血管紧张素Ⅱ1A(AT1A)受体在大鼠肾小管间质病变过程中的作用机理及转换酶抑制剂的调节作用。方法大鼠单侧输尿管结扎术后,分为两组,治疗组用转换酶抑制剂(苯那普利)50mg/L置自来水中喂饲,在手术前24小时开始喂饲直至将大鼠处死时止。对照组单纯用自来水喂饲。利用免疫组化及原位杂交方法观察AT1A受体表达,并同时测定血压和观察组织学变化。结果单侧输尿管梗阻术后10天,对照组大鼠平均动脉压升高(16.6±0.7kPa)并出现明显的肾小管间质改变,治疗组肾小管间质病变明显减轻,平均动脉压降低(14.2±0.6kPa),两组比较P<0.05,免疫组化和原位杂交结果显示对照组肾小管上皮细胞、肾间质及血管周围有大量AT1A受体表达,而治疗组AT1A受体表达明显减弱。结论肾小管间质损伤时可以使AT1A受体表达上调。苯那普利可以减少AT1A受体表达,减缓肾小管间质的损伤,从而进一步解释了肾脏局部的血管紧张素Ⅱ可能主要是与AT1A受体的结合而产生作用。

Objective To investigate the way of interstitial cell loss and its possible relation to Fas expression during the course of renal interstitial fibrosis. Methods The model was induced by unilateral ureteral ligation in rats and the rats were sacrificed at postoperative days 3, 7, 14, 28, 56, and 84. Besides routine morphologic examinations, interstitial collagen type Ⅲ and Fas expression was detected by immunohistochemistry staining and apoptotic cells were determined by terminal deoxynucleotidyl transferase...

Objective To investigate the way of interstitial cell loss and its possible relation to Fas expression during the course of renal interstitial fibrosis. Methods The model was induced by unilateral ureteral ligation in rats and the rats were sacrificed at postoperative days 3, 7, 14, 28, 56, and 84. Besides routine morphologic examinations, interstitial collagen type Ⅲ and Fas expression was detected by immunohistochemistry staining and apoptotic cells were determined by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling(TUNEL). Results Both of the Fas expression and the apoptotic cells in the renal interstitium were continuously increased from day 14 to the end of experiment, with a parallel increase of the interstitial fibrosis. There was a positive correlation between the Fas expression and apoptotic cells in renal interstitium( r=0 94, P<0 05). Conclusion The apoptosis in this model may be pathogenetically related to interstitial cell loss in the course of renal interstitial fibrosis and the apoptosis is probably mediated by Fas/FasL system.

目的 探讨肾间质纤维化形成过程中的肾间质细胞凋亡及其与Fas 表达的关系。方法 建立大鼠单侧输尿管梗阻模型,分别于模型3 天、7 天、14 天、28 天、56 天和84 天处死大鼠。除光镜、电镜观察外,免疫组织化学染色检测胶原Ⅲ和Fas 蛋白表达,末端转移酶介导的dUTP缺口末端标记法检测凋亡细胞。用病理分析软件对肾间质Fas 表达和细胞凋亡进行定量分析。结果 该模型显示进行性的肾间质纤维化。模型14 天后,肾间质Fas 表达阳性率递增,肾间质凋亡细胞亦逐渐增加,且2 者成正相关( r =0-94,P<0-05)。结论 细胞凋亡可能为该模型中肾间质细胞丢失的原因,且Fas/FasL系统可能介导了该细胞凋亡。

Objective To inhibit the expression of ICAM1mRNA with the mouse ICAM1 phosphorothioate antisense oligodeoxynucleotide (ASON) and to investigate the role of ICAM1 in the pathophysialogical process of renal injury in unilateral ureteral obstruction (UUO) animal model Methods After unilateral ureteral ligation, the mice were treated with ICAM1 ASON, which was injected intravenously at the dosage of 1 mg/kg /day every other day for one week Other mice treated with control oligonucleotide or normal saline solution...

Objective To inhibit the expression of ICAM1mRNA with the mouse ICAM1 phosphorothioate antisense oligodeoxynucleotide (ASON) and to investigate the role of ICAM1 in the pathophysialogical process of renal injury in unilateral ureteral obstruction (UUO) animal model Methods After unilateral ureteral ligation, the mice were treated with ICAM1 ASON, which was injected intravenously at the dosage of 1 mg/kg /day every other day for one week Other mice treated with control oligonucleotide or normal saline solution only were taken as controls The expression of ICAM1 protein and the number of Mac1 positive cells were measured by immunohistochemical staining The pathological changes of the obstructed kidney in the mice were analyzed by PASstainingTotal RNA renal tissue was extracted for the analysis of the ICAM1mRNA by methods of Northern blotting Results The expression of ICAM1 protein and the number of Mac1 positive cells were reduced markedly in the obstructed kidneys of the mice treated with the ICAM1 ASON(11014/mm2 vs 27013/mm2) The results of Northern blotting also showed marked decrease of the expression of ICAM1mRNA in the kidney of the mice after treatment with ICAM1 ASON There were marked inflammatory cells infiltration in the tubulointerstitium, markedly dilated tubules, and extraceliular matrix accumulation in the obstructed kidneys on the 7th day after UUO operation The treatment of ICAM1 ASON can alleviate the lesions of the obstructed kidney except for the dilation of the tubules There was no difference in the body weight, liver weight, spleen weight, the level of BUN and SCr, the level of GPT as well as the urine protein of the mice treated with ICAM1 ASON, compared with those in control Oligodeoxynucleotidetreated and saline treated mice Conclusions ICAM1 is a very important factor in the pathogenesis of the UUO animal model The mouse ICAM1 ASON has therapeutic effects on the injury of the obstructed kidney without apparent side effects

目的探讨细胞间粘附分子1(ICAM1)在肾小管间质炎性病变中的作用。方法将荧光标记的ICAM1反义寡核苷酸经静脉注射至正常小鼠体内,观察其分布状况。小鼠在行单侧输尿管梗阻术后从尾静脉注射ICAM1反义寡核苷酸(7只),术后第7天留取输尿管梗阻侧肾脏检测肾组织ICAM1mRNA的表达并作病理检查。同时设立对照寡核苷酸(8只)和注射用水组(6只)作为空白对照。结果ICAM1反义寡核苷酸经静脉注射后主要分布于小鼠的近端肾小管上。与对照组小鼠比较,经反义寡核苷酸治疗的小鼠梗阻肾组织内ICAM1及Mac1阳性细胞的表达明显减少,肾组织中ICAM1mRNA的表达也明显减少,肾小管间质中炎细胞浸润数比对照组明显减轻(110±14个/mm2,270±13个/mm2)、间质增宽的相对面积[(75%±09)%、(254±40)%]、基质积聚及纤维化等病变均明显减轻。治疗组小鼠在肝脏、脾脏重量、血尿素氮、肌酐、丙氨酸转氨酶及尿蛋白的检测上与对照组小鼠相比较差异均无显著意义。结论在非免疫因素引起的肾小管间质损伤中,ICAM1所介导的细胞粘附反应具有重要的作用,ICAM1反义寡核苷...

目的探讨细胞间粘附分子1(ICAM1)在肾小管间质炎性病变中的作用。方法将荧光标记的ICAM1反义寡核苷酸经静脉注射至正常小鼠体内,观察其分布状况。小鼠在行单侧输尿管梗阻术后从尾静脉注射ICAM1反义寡核苷酸(7只),术后第7天留取输尿管梗阻侧肾脏检测肾组织ICAM1mRNA的表达并作病理检查。同时设立对照寡核苷酸(8只)和注射用水组(6只)作为空白对照。结果ICAM1反义寡核苷酸经静脉注射后主要分布于小鼠的近端肾小管上。与对照组小鼠比较,经反义寡核苷酸治疗的小鼠梗阻肾组织内ICAM1及Mac1阳性细胞的表达明显减少,肾组织中ICAM1mRNA的表达也明显减少,肾小管间质中炎细胞浸润数比对照组明显减轻(110±14个/mm2,270±13个/mm2)、间质增宽的相对面积[(75%±09)%、(254±40)%]、基质积聚及纤维化等病变均明显减轻。治疗组小鼠在肝脏、脾脏重量、血尿素氮、肌酐、丙氨酸转氨酶及尿蛋白的检测上与对照组小鼠相比较差异均无显著意义。结论在非免疫因素引起的肾小管间质损伤中,ICAM1所介导的细胞粘附反应具有重要的作用,ICAM1反义寡核苷酸对小鼠单侧输尿管梗阻?

 
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