Results At 2 h and 24 h,rabbits in ARF group had increased blood platelet aggregation(P<0.01) and TXA2,ET(P<0.01),decreased 6-keto-PGF1a(P<0.01)as well as severe ischemic damages of cardiac muscle,compared with rabbits in control group.
It is concluded that the concentrations of thrombin (1 U/ml), ristocetin(1.6 mg/ml), ADP (20 μmol/L) and collagen (2 μg/ml) are optimal for platelets aggregation tests, the internal and extracellular trehalose significantly enhance the aggregation of rehydrated-lyophilized platelets.
GSC with dose of 10.4, 20.8 and 31.2mg/kg could remarkably decrase the platelets aggregation rate(p<0.05) , and markedly prolong the clotting time in blood stasis rats.
GSTT with dose of 10 4, 20 8, and 31 2 mg·kg -1 could remarkably decrase the platelets aggregation rate ( P <0 05), and markedly prolong the clotting time in blood stasis rats.
Objective To obsere influence of RGDS peptide on rat platelet aggregation rate and the ERK1/2 phosphorylation induced by different agonists in vivo and study the relationship between the change of ERK1/2 phosphorylation and the change of platelets aggregation with RGDS peptide.
At the concentration of 1×10~(-3) mol·L~(-1), light Ln~(3+)(La~(3+), Ce~(3+)) inhibits evidently the aggregation of platelet induced by ADP, but heavy Ln~(3+) (Tb~(3+), Y~(3+)) shows reversed effects.
After 8 weeks treatment, Mai-Luo-Tong significantly reduced the aggregation of platelet that decreased from 67. 5±4.1, 75. 8±9. 0 to 39. 7±2. 0, 47. 8±1. 5 respectively in ADP (0. 5, 1. 0μmol/L) induced group.
In vitro,xanthoxylin in the dosages of 0.037 , 0.185 , 0.924 , 9.240 μmol/L significantly inhibited the aggregation of platelet and the production of TXB 2,with the inhibition rate of 22.7%～55.3% and 20.5%～50.7% respectively.
The peptides have an inhibitory effect on platelet aggregation in platelet-enriched blood plasma, when the process is induced by ADP, they also diminish the activity of factor XIIIa in blood plasma.
Repeated intramuscular administration of low molecular weight heparin-collagen complex proved to increase fibrinolytic activity and to decrease platelet aggregation in the blood of rats (11 months) with depressed anticoagulant system.
The elimination of one of thrombotic risk factors (decreasing elevated platelet aggregation) points to possible antithrombotic activity of ATP under these experimental conditions.
The influence of acetyl salicylic acid (ASA) derivatives with platelet-activating factor (PAF) lipid analogs on PAF-induced human platelet aggregation has been studied.
From the above it may be concluded that the preventive effect of API0134 on reocclusion might be due to inhibition of platelets aggregation and promotion of fibrinolysis.
Similarly, collagen-induced aggregation of platelet-rich plasma was inhibited for a longer period and to a greater extent after administration of ASA than after lysine clonixinate.
No statistical differences could be detected between the amount of agonist required to produce 50% aggregation of platelet-rich plasma before and after the subjects consumed the high-DHA diet.
No statistical difference was detected between the amount of agonist required to produce 50% aggregation of platelet-rich plasma before and after the subjects consumed the CLA, with the exception of a decrease in response to collagen.
The specificity of the isolated rabbit aorta for identification and assay of prostaglandin endoperoxides, formed during aggregation of platelet rich plasma (PRP) from rats, was investigated in the superfused organ cascade.
血小板聚集
platelet aggregation
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