The rates of liver metastasis were 38.1%(8/21) in the CO_2 Pneumoperitoneum Group,31.8%(7/22) in the Helium Pneumoperitoneum Group,52.4%(11/21) in the Open Surgery Group,and 31.8%(7/22) in the Control Group,respectively,without significant differences among the four groups(χ~2=2.543,P=0.468).
The high level expression of CD44v6 protein and low level expression of P16 protein were positively correlated with the TNM staging,serosa infiltration,lympho node and liver metastasis of gastric carcinoma(P<0.05).
The high level expression of SLeX,CD44v6 and the low level expression of ED were positively correlated with the Dukes staging,serosa infiltration,lymph node and liver metastasis,as weu as the prognosis of patients of colon cancer(P<(0.05)).
The high level expression of CD15 mRNA, CD44v6 mRNA and the low level expression of nm23H1 mRNA were positively corelated with the Dukes staging,serosa infiltration,lymph node and liver metastasis of colon carcinoma.
CD15和 CD44 v6的 m RNA高表达及 nm 2 3H1m RNA低表达与大肠癌 Dukes分期、浆膜浸润、淋巴结转移、肝脏转移均呈正相关。
The CT findings of peripancreatic tissue invasion correlated with lymphatic metastasis(P=0.031),hepatic metastasis(P=0.025),UICC staging(P<0.001),MVD(P<0.001),VEGF(P=0.02),MMP 2(P=0.01),MMP 9(P=0.003).
The peritoneal and hepatic metastasis rates and 3-year survival rate were studied. Result: The peritoneal and hepatic metastasis rates and 3 years survival rate in treatment group were 21.5%、13.4% and 71.6%. which in control group were 41.2%、22.6% 47.5%.
Results The peritoneal and hepatic metastasis rates and 3 years survival rate in treated group were 20.9%? 13.4% and 74.6%. which in control group were 43.8%?
Results The peritoneal and hepatic metastasis rates and 3-year survival rate in treatment group were 21.9%,12.4% and 74.6%,while in control group were 46.0%,27.4% and 46.8% respectively.
The accuracy was 87.5%(21/24), 87.0%(20/23), 80.0%(12/15), 88.9%(8/9) and 83.3%(5/6) respectively for Gd-DTPA 3D FSPGR dynamic MRI in assessing local extension, vascular invasion, lymph node metastases, liver metastases and peritoneal carcinomatosis of pancreatic carcinoma.
Results:The LOH frequencies of p53 gene were 6/16(37.5%) in primary tumor,6/12 (50.0%) in nodal metastases,and 11/16 (68.8%) in liver metastases,respective- ly. While the LOH frequency of nm23 gene were 4/15(26.7%),4/11 (36.4%),and 6/15(40.0%),respectively.
The high level expression of CD 15 mRNA and the low expression of nm23H1 mRNA were correlated with serosa infiltration, lymyh node and liver metastases.
Results: In this study the tumor occurred in esophagus in one case(3.7%), stomach in 8 cases (29.6%), among which one case was associated with small esophageal leiomyoma, and one case had liver metastases, in 16 cases tumor occurred in small intestine(59.2%), among which one case had liver metastases, and one case had abdominal wall involvement, in 2 cases the tumor occurred in rectum(7.4%).
The expressions of VEGF and FGF - 2 in cancer tissues of colonic liver metastases were examined by immunohistochemical methods(SABC). Results: The incidences of liver metastasis in group HT - 29, group HCT - 116 and group celecoxib were 83.33%, 16.67% and 33.33%, respectively.
The inhibitive effect of SMS 201-995 on the growth of hepatic metastases of colonic adenocarci-noma (CT26) in vivo in BSLB/C mice was investigated by flow cytometry.
The inhibition effect of somatostatin analogue SMS 201 - 995 on the growth of hepatic metastases of colonic adenocarcinoma(CT26) in BALB/c mice was investigated by flow cytometry.
Methods: This study visualized and characterized the receptors for VIP and secretin in the sequence of human tumor-free colon, adenoma, carcinoma, liver metastasis using storage phosphor autoradiography.
A decrease in affinity of VIP receptors was shown in the colonic liver metastasis (Kd = 3.30 nmol) when compared with tumor-free colon (Kd = 0.82 nmol).
In order to establish an animal model with hepatic metastasis intrasplenic inoculation of carcinoma cells from murine uterine cervical carcinoma (U14) was employed.
The results showed that the ALD-A in patient with HCC was significantly elevated as compared with controls and that in patients with cholangiocarcinoma, gastrointestinal cancer without hepatic metastasis, cirrhosis, CAH and benign GI diseases.
Given recent improvements in surgical technique and the development of more effective systemic therapies, the indications for surgical resection of colorectal liver metastases are expanding.
Numerous therapies are available for palliation including surgery, pharmacologic therapy, interventional radiologic therapy, embolization and chemoembolization of hepatic metastases, immunotherapy (Interferon alfa) and chemotherapy.
Individuals should be encouraged to participate in clinical trials to help clarify the role and optimal sequencing of systemic chemotherapy, targeted agents, local therapies, and surgery for patients with hepatic metastases from colorectal cancer.
肝脏转移
liver metastasis
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