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   肝细胞再生 在 急救医学 分类中 的翻译结果: 查询用时:0.028秒
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肝细胞再生
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  “肝细胞再生”译为未确定词的双语例句
    The liver function returned near to normal level on the 7th postoperative day and regeneration of the native liver was confirmed histologically.
    实验组术后第7d肝功能基本恢复正常,组织学检查示原肝细胞再生明显。
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  hepatocyte regeneration
One possibility is that, similar to models of hepatocyte regeneration, β-cells can arise either by neogenesis or replication, depending on the particular stimulus.
      
Hepatocyte growth factor (HGF), a potent hepatocyte mitogen in vitro, triggers hepatocyte regeneration after partial hepatectomy and acute liver cell necrosis induced by chemicals.
      
Hepatocyte regeneration in chronic hepatitis C and interferon treatment: Analysis of immunohistological identification of prolif
      
Hepatocyte regeneration has been widely investigated, with the mitotic index and the incorporation of [3H]thymidine being used as regeneration markers.
      
PE induces atrophy of the ipsilateral lobe and hypertrophy or hyperplasia of the contralateral lobe by hepatocyte regeneration.
      
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PurposeThe aim is to study the therapeutic effect of PRHGF on drug induced acute liver failure in rats.MethodsHepatocyte growth factors were isolated from porcine regenerative liver. Acute liver failure was induced by the administration of thioactamide by gavage.ResultsPRHGF could obviously increase the survival rate of acute liver failure rats ( P <0.05),and sinificantly decrease TB level,ALT activity and TNF level in the serum. It could also prevent hepatocytes necrosis and promote injured liver recovery...

PurposeThe aim is to study the therapeutic effect of PRHGF on drug induced acute liver failure in rats.MethodsHepatocyte growth factors were isolated from porcine regenerative liver. Acute liver failure was induced by the administration of thioactamide by gavage.ResultsPRHGF could obviously increase the survival rate of acute liver failure rats ( P <0.05),and sinificantly decrease TB level,ALT activity and TNF level in the serum. It could also prevent hepatocytes necrosis and promote injured liver recovery at the same time. ConclusionPRHGF has a therapeutic effect on acute liver failure rats induced by TAA.

目的研究猪再生肝肝细胞生长因子 (PRHGF)对急性肝衰竭的治疗作用。方法采用硫代乙酰胺 (TAA)灌胃造成大鼠急性肝衰竭 ,PRHGF腹腔给药 ,观察其治疗作用。结果PRHGF能显著提高急性肝衰竭大鼠存活率 ,降低肝衰竭大鼠血清总胆红素含量、丙氨酸转移酶活性及肿瘤坏死因子的含量 ,与模型组比较差异显著 (P <0 .0 5 ) ;并能明显减少肝细胞坏死 ,促进肝细胞再生。结论PRHGF对TAA所致大鼠急性肝衰竭具有显著的治疗作用

Objective: To observe the dynamic changes of proliferating cell nuclear antigen (PCNA) in t he livers of rats with acute hepatic failure and the influences of hepatocyte gr owth-promoting factors (HGF) on the expression of PCNA. Methods:SD rats were randomly divided into 3 groups: normal g roup,D-GalN group and D-GalN+HGF group. Model for acute hepatic failure was established by injecting D-GalN(1.2 g/kg) into the peritoneal cavity. And all the ra ts in D-GalN+HGF group were injected with HGF(2 mg/kg) per...

Objective: To observe the dynamic changes of proliferating cell nuclear antigen (PCNA) in t he livers of rats with acute hepatic failure and the influences of hepatocyte gr owth-promoting factors (HGF) on the expression of PCNA. Methods:SD rats were randomly divided into 3 groups: normal g roup,D-GalN group and D-GalN+HGF group. Model for acute hepatic failure was established by injecting D-GalN(1.2 g/kg) into the peritoneal cavity. And all the ra ts in D-GalN+HGF group were injected with HGF(2 mg/kg) per 24 h in the same way afte r 2 hours. The expression of PCNA in liver tissue was detected on the 1st,3rd,5t h,7th,9th,11th,13th and 15th day,respectively by immunohistochemical staining with monoclonal antibody to PCNA. Results:The maximum of PCNA-LI in D-GalN group appeared on th e 5 th day and then sharply declined. On the 15 th day the PCNA-LI reached the level of normal group (P>0.05). But the maximum of PCNA-LI in D-GalN+HGF group appeared on the 3 rd day, and then rapidly declined, too. But the PCNA-LI in the D-GalN+HGF group declined slower and lasted longer than tha t in the D-GalN group. The PCNA-LI at every time point in D-GalN+HGF group was s ignificantly higher than that in the D-GalN group at the same time (P <0.01).Conclusion:The remained hepatocytes of the rats w ith acute hepatic failure can regenerate b ut the regemeration is restrained. HGF can raise the expression of PCNA and so can promote the regeneration of hepatocytes.

目的 :观察增殖细胞核抗原 (proliferatingcellnuclearantigen ,PCNA)在急性肝功能衰竭大鼠肝组织中的动态变化及促肝细胞生长素 (hepatocytegrowth promotingfactors ,HGF)对PCNA表达的影响。方法 :SD大鼠随机分为三组 ,即 :正常对照组、D 氨基半乳糖 (D Galactosamine ,D GalN)组和D GalN +HGF组 ,以D GalN1.2g/kg腹腔注射制备大鼠急性肝功能衰竭模型 ,2h后D -GalN +HGF组大鼠每 2 4h腹腔注射HGF 2mg/kg,分别于第 1天、第 3天、第 5天、第 7天、第 9天、第 11天、第 13天、第 15天用S P免疫组织化学技术检测肝组织中PCNA的表达。结果 :D GalN组大鼠肝组织PCNA标记指数 (PCNAlabelingindex ,PCNA LI)在模型建立成功后第 5天达峰值 ,以后急剧下降 ,在第 15天时达到正常对照组水平 (P >0 .0 5 )。D GalN +HGF组大鼠PC NA LI峰值于第 3天出现 ,比D GalN组早 ,持续时间长 ,且各时间...

目的 :观察增殖细胞核抗原 (proliferatingcellnuclearantigen ,PCNA)在急性肝功能衰竭大鼠肝组织中的动态变化及促肝细胞生长素 (hepatocytegrowth promotingfactors ,HGF)对PCNA表达的影响。方法 :SD大鼠随机分为三组 ,即 :正常对照组、D 氨基半乳糖 (D Galactosamine ,D GalN)组和D GalN +HGF组 ,以D GalN1.2g/kg腹腔注射制备大鼠急性肝功能衰竭模型 ,2h后D -GalN +HGF组大鼠每 2 4h腹腔注射HGF 2mg/kg,分别于第 1天、第 3天、第 5天、第 7天、第 9天、第 11天、第 13天、第 15天用S P免疫组织化学技术检测肝组织中PCNA的表达。结果 :D GalN组大鼠肝组织PCNA标记指数 (PCNAlabelingindex ,PCNA LI)在模型建立成功后第 5天达峰值 ,以后急剧下降 ,在第 15天时达到正常对照组水平 (P >0 .0 5 )。D GalN +HGF组大鼠PC NA LI峰值于第 3天出现 ,比D GalN组早 ,持续时间长 ,且各时间点的PCNA LI均明显高于D GalN组 (P <0 .0 1)。结论 :急性肝功能衰竭时 ,残存肝细胞仍有再生能力 ,但其再生过程受到抑制。HGF可以提高PCNA的表达 ,从而促进肝细胞的再生。

Objective To establish the model of auxiliary partial orthotopic liver transplantation (APOLT) and evaluate its supporting effect on acute liver failure.Methods Eighteen healthy female domestic pigs weighing between 20 to 30 kg were used as donors and recipients. Acute liver failure in 12 porcine was successfully induced by injection of galactoramine and lipopolysaccharide through portal vein. In the treated group, the recipients underwent APOLT, left lobes of the recipients were resected and right lobes of...

Objective To establish the model of auxiliary partial orthotopic liver transplantation (APOLT) and evaluate its supporting effect on acute liver failure.Methods Eighteen healthy female domestic pigs weighing between 20 to 30 kg were used as donors and recipients. Acute liver failure in 12 porcine was successfully induced by injection of galactoramine and lipopolysaccharide through portal vein. In the treated group, the recipients underwent APOLT, left lobes of the recipients were resected and right lobes of donors were implanted orthotopically. The suprahepatic cava veins of right liver grafts were implanted end-to-side on the recipient's suprahepatic cava veins. The portal veins of the grafts were implanted end-to-side on the recipient's portal veins. The native bile duct was left intact, and ex situ graft biliary drainage was performed with a silicone tube. The donor artery was implanted side-to-side on the recipient’s splenic artery.Results Seven-day survival rate of the porcine with acute liver failure was only 17 %,while in the porcine receiving APOLT, the 7 day survival rate was 83 %. The liver function returned near to normal level on the 7th postoperative day and regeneration of the native liver was confirmed histologically.Conclusion It is suggested that acute liver failure induced by injection of galactoramine and lipopolysaccharide is an ideal model and pigs suffering from fulminant hepatic failure could achieve long survival and liver regeneration with a temporary support of the auxiliary graft.

目的建立猪原位辅助性肝移植(APOLT)治疗急性肝功能衰竭的动物模型,并评价其治疗效果。方法选取健康雌性良种幼猪18头,其中12头建立急性肝功能衰竭模型,另6头作为肝移植的供者。将急性肝功能衰竭的幼猪随机平均分为2组:对照组,不作任何处理;实验组,进行APOLT术,切除受者肝脏左叶,将修整后的供肝右叶移植于原肝左叶肝床处,供肝肝上下腔静脉与受者肝肝上下腔静脉行端侧吻合,供肝门静脉与受者肝门静脉行端侧吻合,受者脾动脉在结肠后与供肝动脉行端端吻合,胆总管置管外引流。结果对照组7d生存率仅为17%,而实验组为83%。实验组术后第7d肝功能基本恢复正常,组织学检查示原肝细胞再生明显。结论门静脉注射氨基半乳糖+脂多糖诱导的猪急性肝功能衰竭是一个理想的动物模型;APOLT对急性肝功能衰竭具有较好的疗效。

 
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