12 antigens make up 6 systems named as HPA-1-5 and HPA-15. Neonatal alloimmune thrombocytopenia (NAIT) (or fatal-maternal alloimmune thrombocytopenia in utero), Posttransfusion purpura (PTP), Platelet transfusion refractoriness (PTR), and Transplantation associated alloimmune thrombocytopenia (TAAT) are the common clinic alloimmune thrombocytopenic syndromes relevant to HPA.
Conclusions Because PCR RFLP method is plain, fast and reliable for HPA 5 system genotyping, it is suitable for the diagnosis and therapy of neonatal alloimmune thrombocytopenia, posttransfusion purpura, platelet transfusion refractoriness and so on. .
The detection of an HPA-10bw allele in the Chinese population suggests that this rare allele should be consid-ered in platelet alloimmunization,such as neonatal alloimmune thrombocytopenia(NAIT),post-transfusion thrombocyto-penic purpura(PTP) and post-transfusion refractoriness to platelets(PTR).