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| | Effect of acute CrO3 intoxication on rnouse liver were investigated with enzymohistocytoche raistry and raorphology methods. Administration of CrO3 32mg/kg, single intraperitoneally, to mlce resulted in,in the hepatocytes of the perilobular zone, activities of glucose-6-phosphatase and succinate dehydrogenase decreasing, endoplasmic reticula and mitochondria clearly damaged, cloudy swelling, fatty degeneratlon, glycogon content reducing. The results showed that obvious and regional hepatoxicity could be ind... | | 小鼠一次性腹腔内注射CrO_332mg/kg24小时后,肝小叶周边带肝细胞的葡萄糖-6-磷酸酶(G-6-Pase)、琥珀酸脱氢酶(SDH)活性明显下降,线粒体(M)、内质网(ER)等有明显病理改变。肝细胞颗粒变性、脂肪变性、糖原含量下降。表明CrO_3对小鼠肝脏有明显区域性毒性作用,对肝细胞线粒体、内质网的生化功能和超微结构有明显影响。 | | 文摘来源 | |   |
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