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   遗传性改变 的翻译结果: 查询用时:0.513秒
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遗传性改变
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  “遗传性改变”译为未确定词的双语例句
     Epigenetic Changes in Cancer Caused by Non-genotoxic Agents
     非基因毒性剂引起的癌症中基因外表型遗传性改变
短句来源
     Epigenetics, which refers to heritable changes in gene expression that occur without a change in DNA sequence, is a new mechanism of tumorigenesis besides genetic alteration.
     遗传性改变是过去20年肿瘤分子生物学研究的基础。 表遗传是一种由非DNA序列改变引起的,可遗传的基因表达水平的变化,包括DNA甲基化、组蛋白的乙酰化和染色质的构型改变浙江大学博士学位论文等。
短句来源
     Aberrant CpG island methylation in the 5' regulatory regions of genes is well-categorized epigenetic change in most tumors, associated with the silencing of gene expression and plays an important role in tumorigenesis.
     基因5’调控区CpG岛异常甲基化可以通过抑制基因的转录,在不改变遗传信息的前提下导致细胞遗传性改变,在肿瘤的发生过程中扮演重要角色。
短句来源
     But current research indicates that HPV alone cannot cause the carcinoma, and the experiments carried out in vitro shown that some cellular oncogenes are also needed to tranform the cells in addition to HPV infection. Based on these results, our group analyzed the cervical carcinoma specimen by using the oncogene and suppressor gene cDNA microarrays.
     但有研究表明HPV并不能单独致癌,在体外实验中HPV需协同某些细胞癌基因才能产生转化作用,细胞内的遗传性改变可能是宫颈癌的更主要病因。
短句来源
     Conclusions PTC oncogene is a novel activated form of ret oncogene and restricted to the papillary cancer subtype.
     结论 :PTC基因是ret癌基因新的活化形式 ,ret基因的活化仅限于甲状腺乳头状癌类型中 ,可能是乳头状癌的特殊遗传事件 ,而无PTC基因表达的乳头状癌 ,其分子发生机制可能与其他基因的遗传性改变有关。
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  相似匹配句对
     The multifocal electroretinogram in inherited retinoschisis
     遗传性视网膜劈裂症的多焦视网膜电图改变
短句来源
     CHANGES OF HUMAN ERYTHROCYTE SPECTRIN INHEREDITARY SPHEROCYTOSIS
     遗传性球形红细胞增多症红细胞膜收缩蛋白的改变
短句来源
     Inherited characteristics of the plant nutrient
     植物营养遗传性
短句来源
     PEGULATION AND CHANGE
     规则和改变
短句来源
     HEREDITY OF D-PARACOMPACTNESS
     D—仿紧的遗传性
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  heritable change
The model of mutation by transitional change (Freese 1959) predicts that a heritable change in genotype is established when two replications of DNA succeed the initial incorporation of an analogue.
      
What is a mutation Identifying heritable change in the offspring of survivors at Hiroshima and Nagasaki
      
Paramutation is a heritable change in gene expression induced by allele interactions.
      
A mutation occurring in a germ cell is a heritable change in that it can be transmitted from generation to generation.
      
Because the transforming principle caused a heritable change in the bacteria that received it, DNA must be the very stuff of which genes are made.
      
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Purpose To investigate the frequency of ret oncogene expression in human papillary thyroid carcinomas. Methods Expression of PTC oncogene which was a novel rearanged form of the ret tyrosine kinase proto oncogene was detected in fresh tissues of human papillary thyroid carcinomas by RT PCR. Results An activated form of the ret oncogene was found in 6(24%) of 25 papillary carcinomas. By contrast, none of follicular carcinomas, begnin lesions and normal tissues of the thyroid showed PTC positivity. Conclusions...

Purpose To investigate the frequency of ret oncogene expression in human papillary thyroid carcinomas. Methods Expression of PTC oncogene which was a novel rearanged form of the ret tyrosine kinase proto oncogene was detected in fresh tissues of human papillary thyroid carcinomas by RT PCR. Results An activated form of the ret oncogene was found in 6(24%) of 25 papillary carcinomas. By contrast, none of follicular carcinomas, begnin lesions and normal tissues of the thyroid showed PTC positivity. Conclusions PTC oncogene is a novel activated form of ret oncogene and restricted to the papillary cancer subtype. From this finding, we would suggest that ret activation may reprsesnt a specific genetic event, which may be of value in determination of biologic behaviours in human thyroid papillary carcinomas.

目的 :观察人甲状腺乳头状癌中ret癌基因的表达。方法 :应用RT PCR技术研究甲状腺乳头状癌新鲜组织中ret癌基因活化形式PTC基因的表达。结果 :2 5例甲状腺乳头状癌中有 6例 (2 4% )PTC基因表达阳性 ,主要分布于Ⅱ级以上肿瘤中 ;而甲状腺滤泡型癌、甲状腺腺瘤和正常甲状腺组织中PTC均为阴性。结论 :PTC基因是ret癌基因新的活化形式 ,ret基因的活化仅限于甲状腺乳头状癌类型中 ,可能是乳头状癌的特殊遗传事件 ,而无PTC基因表达的乳头状癌 ,其分子发生机制可能与其他基因的遗传性改变有关。因此检测PTC基因可作为判断甲状腺乳头状癌生物学行为的有效参考指标

Background&Objective:Theinfectionwithhumanpapillomavirusandcellulargeneticalterationappeartobenecessaryetiologicalfactorsforcervicalcarcinoma.Thisstudywasdesignedtoinvestigatethegeneticinstabilityincervicalcarcinomatissuesandprovideevidencefordiscoveringnewtumorsuppressorgenesandscreeningdiagnosticmolecularmarkerofcervicalcarcinoma.Methods:Fiftyprimarycervicalcarcinomaspecimensfromhigh-incidenceareawasexaminedthroughlossofheterozygosity(LOH)andmicrosatelliteinstability(MI)analysiswitheightpolymorphicmicrosatellitemarkersonchromosome3,6,11,and18.Results:LOHwasobservedatoneormorelociin33cases(66%).ThehighestfrequencyofthealleliclosswasfoundinD18s474(18q21,40.5%).LOHwasdetectedonothersitesincludingD3s1478(3p21.3-21.2,31.7%),D3s1766(18q21.32,15.0%),D6s260(6p23,23.3%),D11s925(11q22-23,17.9%),D18s35(18q21.1-21.31,8.7%),D18s64(18q21.32,16.7%),andD18s68(18q22.1,27.3%).MIwasdetectedin4cases(8%).Conclusion:DifferentpercentagesLOHonspecificchromosomalregionswerefoundandMIwasveryinfrequentincervicalcarcinomatissues.Theresultsofthecurrentstudystronglysuggestthattheputativesuppressorgene(s)likelytobelocatedonspecificchromosomeregion3por18qinvolveincervicaltumorigenesis....

Background&Objective:Theinfectionwithhumanpapillomavirusandcellulargeneticalterationappeartobenecessaryetiologicalfactorsforcervicalcarcinoma.Thisstudywasdesignedtoinvestigatethegeneticinstabilityincervicalcarcinomatissuesandprovideevidencefordiscoveringnewtumorsuppressorgenesandscreeningdiagnosticmolecularmarkerofcervicalcarcinoma.Methods:Fiftyprimarycervicalcarcinomaspecimensfromhigh-incidenceareawasexaminedthroughlossofheterozygosity(LOH)andmicrosatelliteinstability(MI)analysiswitheightpolymorphicmicrosatellitemarkersonchromosome3,6,11,and18.Results:LOHwasobservedatoneormorelociin33cases(66%).ThehighestfrequencyofthealleliclosswasfoundinD18s474(18q21,40.5%).LOHwasdetectedonothersitesincludingD3s1478(3p21.3-21.2,31.7%),D3s1766(18q21.32,15.0%),D6s260(6p23,23.3%),D11s925(11q22-23,17.9%),D18s35(18q21.1-21.31,8.7%),D18s64(18q21.32,16.7%),andD18s68(18q22.1,27.3%).MIwasdetectedin4cases(8%).Conclusion:DifferentpercentagesLOHonspecificchromosomalregionswerefoundandMIwasveryinfrequentincervicalcarcinomatissues.Theresultsofthecurrentstudystronglysuggestthattheputativesuppressorgene(s)likelytobelocatedonspecificchromosomeregion3por18qinvolveincervicaltumorigenesis.

背景与目的:人乳头瘤病毒的感染以及细胞内的遗传性改变是宫颈癌的主要病因。本研究拟分析人宫颈癌组织部分染色体位点遗传不稳定性,以为宫颈癌相关基因的定位以及筛选宫颈癌诊断分子标志提供依据。方法:应用3、6、11和18号染色体上的8个微卫星多态性位点,对50例原发性宫颈癌活检标本进行杂合性丢失(lossofheterozygosity,LOH)和微卫星不稳定性(microsatelliteinstability,MI)分析。结果:一个或多个位点发生LOH的样本占66%(33/50)。D18s474(18q21)位点的LOH率最高,达40.5%,其它位点的LOH频率为:D3s1478(3p21.3-21.2,31.7%)、D3s1766(18q21.32,15.0%)、D6s260(6p23,23.3%)、D11s925(11q22-23,17.9%)、D18s35(18q21.1-21.31,8.7%)、D18s64(18q21.32,16.7%)、D18s68(18q22.1,27.3%)。MI发生频率很低,仅为8%(4/50)。结论:宫颈癌染色体特定区域存在不同频率的LOH,而MI是宫颈癌中的低频事...

背景与目的:人乳头瘤病毒的感染以及细胞内的遗传性改变是宫颈癌的主要病因。本研究拟分析人宫颈癌组织部分染色体位点遗传不稳定性,以为宫颈癌相关基因的定位以及筛选宫颈癌诊断分子标志提供依据。方法:应用3、6、11和18号染色体上的8个微卫星多态性位点,对50例原发性宫颈癌活检标本进行杂合性丢失(lossofheterozygosity,LOH)和微卫星不稳定性(microsatelliteinstability,MI)分析。结果:一个或多个位点发生LOH的样本占66%(33/50)。D18s474(18q21)位点的LOH率最高,达40.5%,其它位点的LOH频率为:D3s1478(3p21.3-21.2,31.7%)、D3s1766(18q21.32,15.0%)、D6s260(6p23,23.3%)、D11s925(11q22-23,17.9%)、D18s35(18q21.1-21.31,8.7%)、D18s64(18q21.32,16.7%)、D18s68(18q22.1,27.3%)。MI发生频率很低,仅为8%(4/50)。结论:宫颈癌染色体特定区域存在不同频率的LOH,而MI是宫颈癌中的低频事件。染色体3p和18q上的LOH高频区可能存在潜在的宫颈癌相关抑癌基因。

This study was designed to investigate the loss of heterozygosity on chromosome 3,6,11 and 18 from cervical carcinoma tissues and to provide evidence for discovering new tumor suppressor genes and screening diagnostic molecular mark of cervical carcinoma. Loss of heterozygosity was formed by eight polymorphic microsatellite markers on chromosome loci 3,6,11 and 18 with PCR based silver stain method in cervical carcinoma from high incidence area of china. In 50 cervical carcinoma samples, LOH was detected...

This study was designed to investigate the loss of heterozygosity on chromosome 3,6,11 and 18 from cervical carcinoma tissues and to provide evidence for discovering new tumor suppressor genes and screening diagnostic molecular mark of cervical carcinoma. Loss of heterozygosity was formed by eight polymorphic microsatellite markers on chromosome loci 3,6,11 and 18 with PCR based silver stain method in cervical carcinoma from high incidence area of china. In 50 cervical carcinoma samples, LOH was detected of all sites with different frequencies, D3S1478 (3p21.3 21.2, 31.7%), D3S1766(3p14.3 21.1, 15%), D6S260 (6p23, 23.3%), D11S925 (11q23 24, 17.9%), D18S35 (18q21.1 21.31, 8.7%), D18S474 (18q21.1, 40.5%), D18S64 (18q21.32, 16.7%), D18S68 (18q22.1, 27.3%). LOH was detected significantly more frequently at 3p and 18q. Different frequencies of LOH on specific chromosomal regions were found. LOH was a frequent event occurring in the pathogenesis of cervical carcinoma. The results of the current study showed strongly that the putative suppressor gene(s) involved in cervical tumorigenesis was likely to locate at some specific chromosome region.

了解人宫颈癌组织中 3、6、11和 18号染色体部分位点杂合性丢失的分布状况 ,为宫颈癌相关基因的定位以及临床诊断分子标志的筛选提供依据。采用宫颈癌基因组中 3、6、11和 18号染色体上的 8个微卫星标志 ,对源自宫颈癌高发区的宫颈癌活检标本 ,以PCR 变性电泳 银染的方法检测上述位点的杂合性丢失。其中在染色体 3p14、18q2 1等位点存在较高频率的杂合性丢失。结果表明杂合性丢失是宫颈癌癌变过程中常见的遗传性改变 ,宫颈癌中存在杂合性丢失的高频区 ,提示相应位点存在潜在的抑癌基因。

 
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