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Spectral analysis of electromyogram in lumbar muscles: fatigue induced endurance contraction
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| | Rifandin (RFD) is a new antitubercu-lous agent. RFD-resistant strain was ob-tained from M. tuberculosis H_(37)Rv propa-gated on Lowenstein-Jensen medium withconcentration gradients of RFD. The in-corporations of ~3H-UR into H_(37)Rv strainwere significantly inhibited by RFD andrifae oin (RFP) at 5.0μg/ml. RFD at 5.0,1.0 and 0. 1μg/ml also strongly inhibitedthe incorporations. RFD failed to inhibitthe incorporation of ~3H-UR into the resis-tant strain. The amount of ~3H-RFD incor-porated into the susceptible... | | 选用结核杆菌H_(37)Rv及其体外诱导耐利福定菌株,发现利福定能明显抑制~3H-尿苷掺入敏感菌,而~3H-尿苷掺入耐药菌则不受抑制,~3H-利福定掺入敏感菌的量明显高于耐药菌的量;透射电镜观察发现耐药菌包膜较敏感菌为厚。提示利福定抗结核杆菌机理与利福平相同,也是抑制RNA合成;结核杆菌耐利福定与其菌膜屏障通透性降低有关。 | | 文摘来源 | | Rifandin(RFD) is a semisynthetic antituberculous agent made in China. The RFD-resistant strains of Mycobacterium tuberculosis H37Rv, Staphlococus aureus, Proteus vulgaris and Escherichia coli were induced in vitro for the studies of acanning and transmission electron microscopy. There was no difference in the surface between the susceptible and the resistant strains of S. aureus. The number of flagella in the resistant P. vulgaris diminished sharply. The susceptible strain of E. coli treated by RFD became s... | | 选用结核杆菌、金色葡萄球菌、变形杆菌与大肠杆菌及其相应的体外诱导耐利福定菌株进行扫描电镜与透射电镜观察。结果提示细菌耐利福定后在形态及结构方面发生了改变,但因细菌的种类而异。 | | 文摘来源 | | Tachyphylaxis to hemodynamic effects of iv phentolaminc in rabbits was investigated by on line testing A decreasing trend in sensitivity to phentolaminc induced hypotensivc effect was derived When the drug was given for four times at the same dosage of 0.2 mg/ kg to anesthetized rabbits its effect of fall in mean artery pressure was 22%± 3% ,11.7%±24%,8.2%±0.8%and 5.8%±21%.The results of hemodynamic experiments showed that the responsiveness of the fall in the total peripheral resistance (TPR) to iv phcntol... | | 实验采用计算机联机实时分析方法,观察了家兔对酚妥拉明血流动力学效应的快速耐受性。等剂量酚妥拉明(0.2mg/kg)iv 4次,麻醉家兔对降低平均动脉血压的反应率(%)分别为22±3,11.7±24,8.2±0.8和5.8±2.1,呈明显递减趋势。麻醉前ⅳ酚妥拉明(0.5mg/kg)5次诱导耐受时,家兔对酚妥拉明0.25mg/kg ⅳ降低总外周阻力作用从41%±7%下降到24%±8%;此时,对哌唑嗪降低血压和总外周阻力等呈现交叉耐受性;但其心泵功能以及左室等容收缩性仍保持对酚妥拉明的反应性。 | | 文摘来源 | |   | | << 更多相关文摘 |
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