RESULTS The Kp of ketoprofen via stripped skin was about 1.7 times larger than that via intact skin. The permeability was enhanced when coexisting with IPM via either of the two layers and the distribution content of ketoprofen was significantly increased in the stratum corneum.
RESULTS:The permeability coefficient(Kp)of HQ via split skin was 3.29 times larger than that via whole skin layer. The permeability was enhanced 4.95 times(whole skin layer)and 7.49 times(skin without stratum corneum)respectively when coexisting with IPM via intact or via split skin.
Results: The Kp of ISDN via stripped skin was about 1.68 times higher than that of intact skin, IPM could distribute into the viable layer of skin, and significantly increasing the distributing amount ISON in the of ISDN in the stratum corneum and the viable layer of skin as well as an absorbed amount of transdermal accumulation.
RESULTS:The permeability coefficient(Kp)of HQ via split skin was 3.29 times larger than that via whole skin layer. The permeability was enhanced 4.95 times(whole skin layer)and 7.49 times(skin without stratum corneum)respectively when coexisting with IPM via intact or via split skin.
Results The Kp of 5-FU via SC -stripped skin was 2.3 times that via intact skin, and in the presence of IPM, Kp was 1.8 times that via intact skin and 2.4 times that via SC-stripped skin.
RESULTS The Kp value of AT via stripped skin was 3.24 times than that via intact skin. The permeability was enhanced with the KP values being 3.68 and 5.17 times when coexisting with IPM via intact or stripped skin respectively.
Conclusion The permeability of 5-FU is enhanced after the SC is stripped, and IPM can overcome the barrier of SC in intact skin to facilitate 5-FU absorption, but can not enhance the Kp of 5-FU via SC-stripped skin.
Results:The Kp of BB via stripped skin was 2.37 times larger than that via intact skin. The permeability was enhanced when coexisting with IPM via both intact skin and stripped skin.
Neutron diffraction from oriented multilamellar model stratum corneum (SC) membranes provides information on the internal nanostructure and hydration of the lipid bilayer.
The results are obtained using the method based on the creation of permeability microzones (islets) during the local thermal action on stratum corneum.
This paper describes the development of a chromatographic system for analysis of commercial ceramides structurally similar to those found in the stratum corneum.
So, from this formulation steady-state fluxes of AE-1 were observed, representing approximately the same value compared to the unhindered permeation through skin without stratum corneum.