助手标题  
全文文献 工具书 数字 学术定义 翻译助手 学术趋势 更多
查询帮助
意见反馈
   细胞毒效应 在 泌尿科学 分类中 的翻译结果: 查询用时:0.017秒
图标索引 在分类学科中查询
所有学科
泌尿科学
基础医学
肿瘤学
中药学
更多类别查询

图标索引 历史查询
 

细胞毒效应
相关语句
  cytotoxic effect
    IFNαcould enhance the expression of Fas and promote the cytotoxic effect of CH11 on renal cell carcinoma cell; while IL2 and TNFαcould not. Pretreatment of 786-0 renal cell carcinoma cell line with IL2 in combination with IFNαor IFNαtogether with TNFαcould augment the Fas expression and Fas-mediated cell apoptosis.
    IFNα能刺激肾癌细胞 Fas的表达并增强抗 Fas抗体 (CH1 1 )对肾癌细胞的细胞毒效应 ,IL 2、TNFα并不能刺激肾癌细胞 Fas的表达 ,也不能增强抗 Fas抗体 (CH1 1 )对肾癌细胞的细胞毒效应
短句来源
    Cytotoxic effect of CH11 on renal cell carcinoma must rely upon renal cell carcinoma cell to express functionally a certain level of Fas.
    肾癌细胞表达一定水平有功能的 Fas是 CH1 1发挥细胞毒效应的前提。
短句来源
    Chemotherapeutic drug 5-Fu could increase the cytotoxic effect of anti-Fas mAb(CH11) on RCC cell line 786-0 by up-regulating Fas expression, and decrease the cytotoxic effect of RCC cell line 786-0 on Jurkat T lymphocyte by down-regulating FasL expression.
    化疗药物5-Fu能上调肾癌细胞株786-0Fas的表达,并增强肾癌细胞对Fas抗体的细胞毒效应,通过抑制肾癌细胞株786-0FasL表达而降低其攻击JurkatT淋巴细胞的能力。
短句来源
  “细胞毒效应”译为未确定词的双语例句
    Study on the efficacy of scheduled combination of gemcitabine with paclitaxel against human bladder cancer cell lines
    吉西他滨、紫杉醇时序联合对膀胱癌细胞系细胞毒效应研究
短句来源
    Research on the Cytotoxicity of Human Peripheral Blood Mononuclear Cells Activated by Ag85B/IL-2 Fusion Protein Against Bladder Tumor Cells
    分枝杆菌Ag85B/IL-2融合蛋白激活的人PBMC对膀胱肿瘤细胞毒效应的研究
短句来源
    Pretreatment of 786-0 cell line with IFN-γ increased the apoptosis of the cocultured Jurkat cells, but NOK-1 inhibited the effect.
    经干扰素 -γ(IFN -γ)处理后的 786 - 0细胞株可增强对JurkatT淋巴细胞的细胞毒效应。 抗FasL抗体 (NOK - 1)对Fas介导的凋亡有抑制作用。
短句来源
    Results (1) AA in the concentrations of 10, 20 and 40μg/ml did not significantly stimulate the proliferation of hRIFs and HK-2 ( P > 0. 05) and increase LDH release rates of HK-2 and hRIFs (P > 0. 05) .
    结果 (1)AA在10、20和40 μg/ml时对HK-2及hRIFs无刺激增殖及细胞毒效应(P>0.05);
短句来源
    【Objective】To research the cytotoxicity of human peripheral blood mononuclear cells(PBMC) activated by Ag85B/IL-2 fusion protein against bladder tumor cells.
    【目的】研究分枝杆菌Ag85B/IL-2融合蛋白激活的人外周血单个核细胞(PBMC)对膀胱肿瘤的细胞毒效应
短句来源
更多       
查询“细胞毒效应”译词为用户自定义的双语例句

    我想查看译文中含有:的双语例句
例句
为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法,我们为您准备了出自英文原文的大量英语例句,供您参考。
  cytotoxic effect
Cytotoxic Effect of Coscinium Fenestratrum (Gaertn.) Colebr.
      
Increased inhibitory effect of methanol extracts over berberine demonstrates the occurrence of other cytotoxic principles along with main active principle berberine or other factors enhancing the cytotoxic effect of berberine.
      
The generation of ROS may play an important role in the cytotoxic effect.
      
At the stage of acute inflammation they are due to cytotoxic effect of the lymphocytes, monocytes, and macrophages.
      
The sensitivity of stromal stem cells (CFU-f) from rat bone marrow and fetal liver to the cytotoxic effect of 5-fluorouracil (5-FU) was compared in vivo and in vitro.
      
更多          


For targeting therapy, genetic engineering antibodies would be preferred to mouse McAbs as the foreign immunogobulin might ilicit an anti-globulin response and hypersensitivity. Functional antibody genes coming from a hybridoma antibody that reacted with human urinary bladder cancer cells have been cloned into an E. Coli expressive vector containing a portion of pseudomonas exotoxin gene. The latter could produce a cytotoxin protein. The results revealed that the expressed protein could block the binding of...

For targeting therapy, genetic engineering antibodies would be preferred to mouse McAbs as the foreign immunogobulin might ilicit an anti-globulin response and hypersensitivity. Functional antibody genes coming from a hybridoma antibody that reacted with human urinary bladder cancer cells have been cloned into an E. Coli expressive vector containing a portion of pseudomonas exotoxin gene. The latter could produce a cytotoxin protein. The results revealed that the expressed protein could block the binding of parent McAb with urinary bladder cancer cells so as to kill the malignant cells Although the blocking activity was not so strong, it might be possible to select a better and more suitable targeting product in the future.

为了减少异源抗体免疫原性和增强其抗体细胞毒效应,利用基因工程抗体技术将已获得的具有与人膀胱癌细胞结合活性的单抗重链可变区基因(VH)亚克隆至构建好的含有重组绿脓杆菌外毒素基因(PE)的表达载体中,经大肠杆菌表达,研究制备具有导向治疗作用的重组免疫毒素。经间接免疫荧光试验等技术初步鉴定,所获得的免疫毒素与人膀胱癌细胞具有一定的结合效应,为进一步临床应用研究奠定了基础

Objective To investigate the effect of FasL protein expression on T lymphocytes apoptosis in renal cell carcinoma (RCC). Methods FasL expression was assayed by means of immunohistochemical VP technique, and the apoptosis of T lymphocytes infiltrating renal tumor was determined by TUNEL assay in 44 cases of RCC. Jurkat cell line and 786-0 RCC cell line were cocultured with or without cytokine IFN-γ and anti-FasL monoclonal antibody (NOK-1) to detect the Jurkat cell apoptosis by using flow cytometry (FCM). Results...

Objective To investigate the effect of FasL protein expression on T lymphocytes apoptosis in renal cell carcinoma (RCC). Methods FasL expression was assayed by means of immunohistochemical VP technique, and the apoptosis of T lymphocytes infiltrating renal tumor was determined by TUNEL assay in 44 cases of RCC. Jurkat cell line and 786-0 RCC cell line were cocultured with or without cytokine IFN-γ and anti-FasL monoclonal antibody (NOK-1) to detect the Jurkat cell apoptosis by using flow cytometry (FCM). Results The FasL expression rate was 46.5% in RCC, higher than in normal kidney tissue (23.2%, P <0.05), and had a close positive correlation to the tumor-infiltrating lymphocytes apoptosis (33.1%, r =0.96, P <0.01). That is to say the FasL(+) 786-0 RCC cell line induced the apoptosis of Jurkat T lymphocytes. Pretreatment of 786-0 cell line with IFN-γ increased the apoptosis of the cocultured Jurkat cells, but NOK-1 inhibited the effect. Conclusion FasL expression in RCC tissue can kill the Fas(+) T lymphocytes by Fas/FasL pathway, which may be one of the ways RCC escapes immune recognition.

目的 探讨凋亡相关基因产物FasL蛋白在肾癌中的表达及对T淋巴细胞凋亡的影响。方法 采用免疫组织化学方法 (VP法 )对 44例肾癌组织和 10例相邻正常肾组织FasL蛋白表达进行检测 ;TUNEL法检测 44例肾癌组织浸润性T淋巴细胞的凋亡 ;体外培养 786 - 0肾癌细胞株和JurkatT淋巴细胞 ,流式细胞仪 (FCM)检测JurkatT淋巴细胞的凋亡。结果 肾癌组织FasL阳性表达率 46 .5 % ,高于正常肾组织中FasL的表达 (2 3.2 % ,P <0 0 5 ) ;肾癌浸润性T淋巴细胞凋亡率 33.1% ,和肾癌FasL表达呈正相关 (r =0 .96 ,P <0 .0 1) ;表达FasL的786 - 0肾癌细胞株可引起Fas(+)的JurkatT淋巴细胞凋亡。经干扰素 -γ(IFN -γ)处理后的 786 - 0细胞株可增强对JurkatT淋巴细胞的细胞毒效应。抗FasL抗体 (NOK - 1)对Fas介导的凋亡有抑制作用。结论 肾癌组织免疫逃避机制之一是通过高表达FasL而引起肾癌浸润性T淋巴细胞凋亡 ;肾癌组织表达FasL能通过Fas FasL通路主动杀伤Fas(+...

目的 探讨凋亡相关基因产物FasL蛋白在肾癌中的表达及对T淋巴细胞凋亡的影响。方法 采用免疫组织化学方法 (VP法 )对 44例肾癌组织和 10例相邻正常肾组织FasL蛋白表达进行检测 ;TUNEL法检测 44例肾癌组织浸润性T淋巴细胞的凋亡 ;体外培养 786 - 0肾癌细胞株和JurkatT淋巴细胞 ,流式细胞仪 (FCM)检测JurkatT淋巴细胞的凋亡。结果 肾癌组织FasL阳性表达率 46 .5 % ,高于正常肾组织中FasL的表达 (2 3.2 % ,P <0 0 5 ) ;肾癌浸润性T淋巴细胞凋亡率 33.1% ,和肾癌FasL表达呈正相关 (r =0 .96 ,P <0 .0 1) ;表达FasL的786 - 0肾癌细胞株可引起Fas(+)的JurkatT淋巴细胞凋亡。经干扰素 -γ(IFN -γ)处理后的 786 - 0细胞株可增强对JurkatT淋巴细胞的细胞毒效应。抗FasL抗体 (NOK - 1)对Fas介导的凋亡有抑制作用。结论 肾癌组织免疫逃避机制之一是通过高表达FasL而引起肾癌浸润性T淋巴细胞凋亡 ;肾癌组织表达FasL能通过Fas FasL通路主动杀伤Fas(+)的JurkatT淋巴细胞

Objective To investigate the effects of aristolochic acid(AA) on cell proliferation, cytotoxicity and mRNA expression of some cytokines in cultured human renal interstitial fibroblasts (hRIFs) and human renal tubular epithelial cell line (HK-2). Methods (1) The cell proliferation of hRIFs and HK-2 was determined by MTT method. (2) The cytotoxicity of A A to hRIFs and HK-2 was determined by lactate dehydrogenase (LDH) release test. (3) The mRNA expression of type Ⅰ Collagen (Col Ⅰ), transforming growth factor-β(TGF-β),...

Objective To investigate the effects of aristolochic acid(AA) on cell proliferation, cytotoxicity and mRNA expression of some cytokines in cultured human renal interstitial fibroblasts (hRIFs) and human renal tubular epithelial cell line (HK-2). Methods (1) The cell proliferation of hRIFs and HK-2 was determined by MTT method. (2) The cytotoxicity of A A to hRIFs and HK-2 was determined by lactate dehydrogenase (LDH) release test. (3) The mRNA expression of type Ⅰ Collagen (Col Ⅰ), transforming growth factor-β(TGF-β), plasminogen activator inhibitor-1 (PAI-1), matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TTMP-1) was detected semiquantitatively with reverse transcription-polymerase chain reaction (RT-PCR). Results (1) AA in the concentrations of 10, 20 and 40μg/ml did not significantly stimulate the proliferation of hRIFs and HK-2 ( P > 0. 05) and increase LDH release rates of HK-2 and hRIFs (P > 0. 05) . (2) AA in the concentrations of 80 and 160μg/ml significantly elevated LDH release rates of HK-2 and hRIFs ( P < 0. 01); LDH release rates were increased by 1.88- and 4.86-fold in HK-2 respectively, and by 1.72- and 1.94-fold in hRIFs respectively as compared to control group. (3) When stimulated by AA of 40μg/ml for 16 hours, the mRNA expression of TGF-β, PAI-1 and TIMP-1 in HK-2 was significantly upregulated ( P <0. 05) and the mRNA expression of Col Ⅰ, TGF-β, PAI-1 and TIMP-1 in hRIFs was also significantly upregulated ( P < 0. 05) . The mRNA levels of TGF-β, PAI-1 and TIMP-1 in HK-2 were increased by 1. 65-, 1. 44- and 1. 30-fold respectively, and the mRNA levels of Col Ⅰ, TGF-β, PAI-1 and TIMP-1 in hRIFs were increased by 1. 47-,1. 41-,2. 32-and 1.41-fold respectively as compared to control group. No above-mentioned effects were found in the concentrations of 10 and 20μg/ml of AA. Conclusions The cytotoxic effects of AA in the concentrations of 80 and 160μg/ml on HK-2 may be related to pathogenesis of acute AA nephropathy. AA in the concentration of 40μg/rnl can significantly upregulate mRNA expression of TGF-β, PAI-1 and TIMP-1 of hRIFs and HK-2, and also upregulate Col Ⅰ mRNA expression of hRIFs, which may be related to pathogenesis of chronic AA nephropathy.

目的 探讨马兜铃酸(AA)对体外培养的人肾小管上皮细胞株(HK-2)及人肾间质成纤维细胞(hRIFs)的作用。方法 (1)用MTT比色法检测细胞增殖反应。(2)用乳酸脱氢酶(LDH)释放试验检测AA的细胞毒作用。(3)应用RT-PCR观察细胞Ⅰ型胶原(Col Ⅰ)、转化生长因子β(TGF-β)、纤溶酶原激活物抑制物1(PAI-1)、基质金属蛋白酶1(MMP-1)及金属蛋白酶组织抑制物1(TIMP-1)的mRNA表达。结果 (1)AA在10、20和40 μg/ml时对HK-2及hRIFs无刺激增殖及细胞毒效应(P>0.05);而在80和160μg/ml时却能明显杀伤上述细胞(P<0.01)。(2)40μg/ml浓度的AA孵育细胞16 h,可显著上调HK-2的TGF-β、PAI-1和TIMP-1 mRNA表达(P<0.05),也可上调hRIFs的Col Ⅰ、TGF-β、PAI-1和TIMP-1 mRNA的表达(P<0.05);而10和20μg/ml浓度的AA未观察到上述作用。结论 80和160μg/ml AA对HK-2有明显细胞毒作用,此作用可能与急性马兜铃酸肾病发病相关;而40μg/ml AA可上调...

目的 探讨马兜铃酸(AA)对体外培养的人肾小管上皮细胞株(HK-2)及人肾间质成纤维细胞(hRIFs)的作用。方法 (1)用MTT比色法检测细胞增殖反应。(2)用乳酸脱氢酶(LDH)释放试验检测AA的细胞毒作用。(3)应用RT-PCR观察细胞Ⅰ型胶原(Col Ⅰ)、转化生长因子β(TGF-β)、纤溶酶原激活物抑制物1(PAI-1)、基质金属蛋白酶1(MMP-1)及金属蛋白酶组织抑制物1(TIMP-1)的mRNA表达。结果 (1)AA在10、20和40 μg/ml时对HK-2及hRIFs无刺激增殖及细胞毒效应(P>0.05);而在80和160μg/ml时却能明显杀伤上述细胞(P<0.01)。(2)40μg/ml浓度的AA孵育细胞16 h,可显著上调HK-2的TGF-β、PAI-1和TIMP-1 mRNA表达(P<0.05),也可上调hRIFs的Col Ⅰ、TGF-β、PAI-1和TIMP-1 mRNA的表达(P<0.05);而10和20μg/ml浓度的AA未观察到上述作用。结论 80和160μg/ml AA对HK-2有明显细胞毒作用,此作用可能与急性马兜铃酸肾病发病相关;而40μg/ml AA可上调HK-2及hRIFs的TGF-β、PAI-1和TIMP-1 mRNA表达,并能上调hRIFs的Col Ⅰ mRNA表达,此作用可能与慢性马兜铃酸肾病发病相关。

 
<< 更多相关文摘    
图标索引 相关查询

 


 
CNKI小工具
在英文学术搜索中查有关细胞毒效应的内容
在知识搜索中查有关细胞毒效应的内容
在数字搜索中查有关细胞毒效应的内容
在概念知识元中查有关细胞毒效应的内容
在学术趋势中查有关细胞毒效应的内容
 
 

CNKI主页设CNKI翻译助手为主页 | 收藏CNKI翻译助手 | 广告服务 | 英文学术搜索
版权图标  2008 CNKI-中国知网
京ICP证040431号 互联网出版许可证 新出网证(京)字008号
北京市公安局海淀分局 备案号:110 1081725
版权图标 2008中国知网(cnki) 中国学术期刊(光盘版)电子杂志社