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   细胞毒效应 在 肿瘤学 分类中 的翻译结果: 查询用时:0.041秒
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细胞毒效应
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  cytotoxic effect
    The cytotoxic effect of immunoradiotherapeutic agent 35 S McAb SZ39 against glioma
    抗胶质瘤免疫放疗制剂~(35)S标记单抗SZ39细胞毒效应
短句来源
    The results suggest that Rh 6DGN possesses a protracted direct cytotoxic effect against the hepatoma cells. When combined with 2-DG, Rh 6DGN is efficacious for mouse Hep A hepatoma.
    上述资料表明Rh 6GDN有直接肝癌细胞毒效应,与2-DG合用于Hep A肝癌小鼠有明显疗效。
短句来源
    (4) Cytokines such as IL-4 and TNF could work in coordination with r8 T cells to increase the cytotoxic effect;
    (4)某些细胞因子可协同提高γδT细胞的细胞毒效应,如IL-4,TNF;
短句来源
    Conclusions 35 S McAb SZ39 has a strong selective cytotoxic effect against glioma cells and is of good prospect as an immunoradiotherapeutic agent.
    结论35S-McAbSZ39具有高效的靶选择性细胞毒效应,作为一种免疫放疗制剂具有良好的应用前景。
短句来源
    Followed the prodrug fludarabine incubation, the cytotoxic effect, bystander effect and apoptosis induction of PNP/fludarabine suicide gene system on BEL7402 cells were detected by methyl thiazolyl tetrazolium (MTT) colorimetric method and Annexin V-FITC apoptosis detection kit, respectively.
    分别应用四甲基偶氮唑蓝(MTT)比色法和AnnexinV鄄FITC凋亡检测试剂盒检测PNP/fludarabine自杀基因系统对BEL7402细胞的细胞毒效应、旁观者效应和诱导凋亡作用。
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  cellular cytotoxicity
    MTT colorimetric assay and 3 H-TdR release assay were used to test the cellular cytotoxicity (MGC 803 T and control) related to TNF-α.
    用MTT比色法、3H—TdR释放法检测MGC803T及未转染的人胃癌细胞MGC803(MGC803N)细胞表面TNF—α的细胞毒效应
短句来源
  cytotoxicity effect
    In the normal cells, v5Ad4 didn' t show visible cytotoxicity effect.
    在人胚肺正常二倍体细胞中,v5Ad4没有表现出可见的细胞毒效应
短句来源
    Results CTX had significant cytotoxicity effect on the above cancer cell lines in vitro. The IC50(24 hours in cubation) was 1.04,0.5,1.82,1.76 and 1.05 μg/ml for CNE,YAC,S 180,HELA,and Ho8990 cell,respctively.
    结果 CTX对上述体外培养的肿瘤细胞有明显的细胞毒效应 ,作用 2 4h的半数抑制浓度分别为 1.0 4,0 .5 0 ,1.82 ,1.76和 1.0 5 μg/ml ;
短句来源
    Conclusion The transgenetic dendritic cells showed cytotoxicity effect by activating T lymphocytes.
    结论 体外诱导扩增的 DC能够转染 IgVH1核酸质粒,体外激活T淋巴细胞,产生特异性细胞毒效应
短句来源
  “细胞毒效应”译为未确定词的双语例句
    MICA might increase the sensitivity of the breast cancer to NK cells by activating NKG2D on the NK cells.
    乳腺癌细胞表面表达的MICA分子可上调NK细胞表面NKG2D的表达,激发NK细胞对乳腺癌细胞的细胞毒效应
短句来源
    MTT Colorimetric Assay for Testing Cytotoxic Activity of MGC 803 T
    MTT比色法检测MGC_(803)~T细胞毒效应的研究
短句来源
    The relationship between NO and the anti-tumor cytotoxic function of macrophages
    NO与巨噬细胞抗肿瘤细胞毒效应的关系
短句来源
    MTT Colorimetric Assay for Cytotoxic Activity of AU_(14-1) mediated LAK
    MTT法检测AU_(14-1)介导LAK细胞的细胞毒效应
短句来源
    Study of the cytotoxicity of combination of indole-3-acetic(IAA) and horseradish peroxidase(HRP) on BXPC-3 cells in pancreatic cancer
    IAA与HRP联合作用对人胰腺癌BXPC-3的细胞毒效应
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  cytotoxic effect
Cytotoxic Effect of Coscinium Fenestratrum (Gaertn.) Colebr.
      
Increased inhibitory effect of methanol extracts over berberine demonstrates the occurrence of other cytotoxic principles along with main active principle berberine or other factors enhancing the cytotoxic effect of berberine.
      
The generation of ROS may play an important role in the cytotoxic effect.
      
At the stage of acute inflammation they are due to cytotoxic effect of the lymphocytes, monocytes, and macrophages.
      
The sensitivity of stromal stem cells (CFU-f) from rat bone marrow and fetal liver to the cytotoxic effect of 5-fluorouracil (5-FU) was compared in vivo and in vitro.
      
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  cellular cytotoxicity
In contrast, both NKG2D and CD16 are activating NK receptors that trigger the NK-cell lysis of various tumor and virally infected cells through either direct ligand engagement or antibody-dependent cellular cytotoxicity (ADCC).
      
Third International Conference on Bispecific Antibodies and Targeted Cellular Cytotoxicity, Rosa Marina Hotel, Ostuni Brindisi,
      
A therapeutical splenectomy, on the other hand, did not affect cellular cytotoxicity in the case of a hairy cell leukemia.
      
Spontaneous cell-mediated (SCMC) and antibody-dependent cellular cytotoxicity (ADCC) in patients with acute and chronic active h
      
Spontaneous (SCMC) and antibody-dependent (ADCC) cellular cytotoxicity was studied in patients with acute viral hepatitis B and chronic active hepatitis (CAH) B and non-A, non-B.
      
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  cytotoxicity effect
To investigate whether these features were associated with the cytotoxicity effect of TM on Escherichia coli, a series of mutants were constructed and expressed in the E.
      
Cytotoxicity effect of algal polysaccharides on HL60 cells
      
In contrast, for the incubation with SiHa cells of these conjugates, there was no significant cytotoxicity effect.
      
The combination of IL-1 and TNF, which more likely resembles culture supernates of activated macrophages, produced an additive antitumor cytotoxicity effect.
      
Lysostaphin cytotoxicity effect is much less than the surface active agent, sodium laurate.
      
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The role of inbred LACA mouseperitoneal macrophages against tumorand effect of thymic peptide (TP)on the macrophage tumoricidal acti-vity in vitro and in vivo were studied. Macrophage cytolytic and cytos-tatic activities were measured by an18-hr ~(51)Cr-release assay and a 24-hrtritiated-thymidine incorporation in-hibition assay respectively.Sarcoma180 (S180) was used as target cell.Macrophages were also tested for anti-tumor activity in vivo by injecting amixture of peritoneal macrophages andS180 cells into...

The role of inbred LACA mouseperitoneal macrophages against tumorand effect of thymic peptide (TP)on the macrophage tumoricidal acti-vity in vitro and in vivo were studied. Macrophage cytolytic and cytos-tatic activities were measured by an18-hr ~(51)Cr-release assay and a 24-hrtritiated-thymidine incorporation in-hibition assay respectively.Sarcoma180 (S180) was used as target cell.Macrophages were also tested for anti-tumor activity in vivo by injecting amixture of peritoneal macrophages andS180 cells into normal LACA micesubcutaneously.It was found that re-sident macrophages of normal and tu-mor-bearing mice possessed both cyto-lytic and cytostatic activities whichwere nonspecific in nature.Targetcell killing by macrophages wasstrongly influenced by effector to targetcell ratio (E:T);a low concentrationof macrophages (E:T<5:1) augment-ed S180 cell proliferation.Adminis-tration of TP together with cyclopho-sphamide (CY) to tumor-bearing micewas able to overcome the suppressioninduced by CT on macrophage.Invivo experiments showed that macrophages from tumor-bearing mice,rather than those from normal mice,were capable of prolonging mean sur-vival time (MST) and increasingsurvival rate of tumor-bearing miceat E:T of 5:1.At E:T of 2.5:1,macrophages from TP-treated tumor-bearing mice prolonged MST significantly,but those from untreated tumor-bearing mice failed to do so.TPcould not enhance cytotoxic activityof resident macrophages after in vitroincubation for 24hrs while ConAconditioned medium could.It ap-pears that TP,a immunomodulatingagent,affects to some extent the anti-tumor activity of macrophage indirect-ly.

用~(51)Gr释放、~3H-TdR掺入抑制及混合接种等方法观察了LACA纯系小鼠腹腔巨噬细胞体内体外对于S180肿瘤细胞的细胞毒效应以及胸腺肽对此作用的影响。结果表明,正常鼠和带瘤鼠的巨噬细胞在体外均可抑制或杀伤肿瘤细胞,E/T比例影响这一效应,E/T比例<5:1时巨噬细胞促进S180细胞的体外增殖。与单独应用环磷酰胺相比较,胸腺肽与环磷酰胺合用可增强巨噬细胞的细胞毒功能。正常鼠的巨噬细胞在体内混合接种实验中无作用,带瘤鼠的巨噬细胞在E/T比例为5:1时可延长生存期,提高存活率;而经胸腺肽处理的带瘤鼠的巨噬细胞在E/T比例为2.5:1时即可延长生存期。胸腺肽体外不能直接激活巨噬细胞,而Con A条件培液则具有这一功能。提示胸腺肽可通过一间接途径对带瘤鼠的巨噬细胞的抗瘤功能表现某种程度的调节作用。

The cytotoxic and therapeutic effects of rhodamine 6GDN (Rh 6GDN), a fluorescent dye, on mouse Hep A hepatoma were studied 6, 18, 80, 42 and 90 hours after an i. p. injection at a dose of 2.0mg/kg body weight. The inhibitory rate of the Hep A hepatoma cells by Rh 6GDN was 9.1, 42.4, 47.8, 57.9 and 88.6% at different times respectively. When 3 repeated i. p. doses of normal saline 0.4ml, Rh 6GDN 0.5mg/kg, 2-deoxy-D-glucose (2-DG) 1.0g/kg, Rh 6GDN 0.5mg/kg plus 2-DG1.0g/kg and 5-FU 10 0mg/kg were given to different...

The cytotoxic and therapeutic effects of rhodamine 6GDN (Rh 6GDN), a fluorescent dye, on mouse Hep A hepatoma were studied 6, 18, 80, 42 and 90 hours after an i. p. injection at a dose of 2.0mg/kg body weight. The inhibitory rate of the Hep A hepatoma cells by Rh 6GDN was 9.1, 42.4, 47.8, 57.9 and 88.6% at different times respectively. When 3 repeated i. p. doses of normal saline 0.4ml, Rh 6GDN 0.5mg/kg, 2-deoxy-D-glucose (2-DG) 1.0g/kg, Rh 6GDN 0.5mg/kg plus 2-DG1.0g/kg and 5-FU 10 0mg/kg were given to different groups of mice 1, 3, end 5 days after ascites transplantation, their respective mean survival time was 14.3, 17.7, 16.6, 20.7 (p<0.01) and 21.6 days (p<0.01). The longest survival time was 16, 30, 26, 32 and 28 days. The results suggest that Rh 6DGN possesses a protracted direct cytotoxic effect against the hepatoma cells. When combined with 2-DG, Rh 6DGN is efficacious for mouse Hep A hepatoma.

Hep A腹水肝癌小鼠腹腔注射亲癌荧光染料罗丹明6GDN(Rh 6GDN)2.0mg/kg后,肝癌细胞抑制现象出现缓慢而作用持久。癌细胞呈变性形态学改变。于接种肿瘤后第1、3、5d分别注射生理盐水0.4ml、Rh 6GDH 0.5mg/kg、2-脱氧葡萄糖(2-DG)1.0g/kg、Rh 6GDN 0.5mg/kg加2-DG 1.0g/kg和5-FU10.0mg/kg后,各组肝癌小鼠的平均生存天数分别为14.3、17.7、16.6、20.7(p<0.01)和21.6d(p<0.01)。上述资料表明Rh 6GDN有直接肝癌细胞毒效应,与2-DG合用于Hep A肝癌小鼠有明显疗效。

The effects of the activition of SPA and SCA to peritoneal macrophages andsplenic NK cells were observed by DNA released assay of ~(125)I-udR labeled tumorcells. The result showed that SPA and SPC may enhanced the cytotoxic activities ofthe macrophages and NK cells odviously, but they hadn't direct cytotoxic effects.

本文通过~(125)Ⅰ-udR标记肿瘤细胞DNA释放试验观察了SPA和SAC直接体内注射对带瘤小鼠腹腔巨噬相胞细胞毒和脾脏NK细胞细胞毒的影响,SPA和SAC对瘤细胞的直接毒效应。结果表明,SPA和SAC均能使带瘤小鼠巨噬细胞、NK细胞细胞毒活性明显增强,二者无直接瘤细胞毒效应。这些提示葡萄球菌A蛋白体内注射的抗肿瘤机制与其增强巨噬细胞和NK细胞细胞毒活性有关,与直接瘤细胞毒作用无关。

 
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