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  relative bioavailability
Conclusions: The results confirm that the relative bioavailability of β-carotene depends largely on the source of b-carotene and demonstrate the superior bioavailability of β-carotene powder in comparison to that in carrot juice.
      
The relative bioavailability in humans of elemental iron powders for use in food fortification
      
A comparison between microcrystalline and conventional phenytoin preparations: Relative bioavailability and steady-state plasma
      
The relative bioavailability was about 2-3 times higher after bacampicillin as compared to ampicillin.
      
Relative bioavailability was 105% (tablet/capsule).
      
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  bioavailability
This indicated that the accumulation pathways of Cu and the processes affecting the bioavailability of Cu to the mussel are different from those for Cd, Pb, and Zn.
      
Such flooding reaching an amplitude of about ten meters causes dramatic changes in the bioavailability of nutrients and oxygen levels and poses extreme constraints for plant survival and reproductivity.
      
We evaluated the chemical activity and bioavailability of heavy metals in the tidal flat based on the molar ratio of simultaneously extracted metals (SEM) and AVS.
      
This reduces the molecular weight and increases the bioavailability, indicating better ADME properties.
      
In this paper, progresses in researches on physiology of Zn deficiency in animals, phytate effect on bioavailability of Zn, and role of phytase in healing Zn deficiency of animals were reviewed.
      
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The bioavailability of eye drops (prepared with saline and buffered solutions) of Bao Gong Teng A(isolated from Erycibe obtusfolia Benth) have been studied by using the pharmacological response(miotic action). The change in pupillary diameter of the rabbit eye is chosen as a graded quantitative pharmacological response to indicate the change of intensity. The observed pharmacological data are converted, via the use of a dose-effect curve, to values corresponding to the relative biophasic drug levels. The relative...

The bioavailability of eye drops (prepared with saline and buffered solutions) of Bao Gong Teng A(isolated from Erycibe obtusfolia Benth) have been studied by using the pharmacological response(miotic action). The change in pupillary diameter of the rabbit eye is chosen as a graded quantitative pharmacological response to indicate the change of intensity. The observed pharmacological data are converted, via the use of a dose-effect curve, to values corresponding to the relative biophasic drug levels. The relative bioavailability of saline solution of Bao Gong Teng A is computed from the ratio of the total areas under the curves (AUG) plotted with the relative biophasic drug levels of both solutions versus time. The results demonstrate that in comparison with saline solution the relative bioavailability of buffered solution of Bao Gong Teng A is 60% (P<0.05).

本文报告用药理指标测定了两种包公藤甲素缩瞳剂的相对生物利用度。兔瞳孔直径的变化选作为分级定量的药理效应强度指标。观察的药理效应强度通过剂量-效应曲线,转换成相应的生物相药物浓度。然后,通过药一时曲线下面积计算包公藤甲素两种缩瞳剂的相对生物利用度。结果表明,用磷酸缓冲液(pH7)配制的缩瞳剂与用氯化钠调整渗透压配制的缩瞳剂(pH6)相比,其相对生物利用度为60%(P<0.05)。

The ability of magnesium trisilicate to adsorb tetracycline and its relation to pHof the medium have been investigated UV-spectrophotometrically.The effect ofmagnesium trisilicate on absorbing tetracycline and its effect in the presence of somesurfactants and citric acid in vivo have also been studied by usng the data ofurinary excretion.The relative bioavailability of three different tetracyclinesuspensions has been determined and the parameters have been statistically comparedsimultaneously.The results have...

The ability of magnesium trisilicate to adsorb tetracycline and its relation to pHof the medium have been investigated UV-spectrophotometrically.The effect ofmagnesium trisilicate on absorbing tetracycline and its effect in the presence of somesurfactants and citric acid in vivo have also been studied by usng the data ofurinary excretion.The relative bioavailability of three different tetracyclinesuspensions has been determined and the parameters have been statistically comparedsimultaneously.The results have shown that,the adsorptive capacity of magnesium■risilicate is enhanced,as the pH is raised.Sodium lauryl sulfate and citric acid haveexhibited a significant desorption on magnesium silicate in vitro,but Brij-35hasn't.The simultaneous oral administration of tetracyclline and magnesiumtrisililcate can markedly reduce the absorption of the former(p<0.05).Simultaneousadministration of 0.15g sodium lauryl sulfate and 0.3g magnesium trisilicate inhibitsthe adsorption to a certain extent,the inhibition of tetracycline adsorption ontomagnesium trisilicate will no longer be strengthened as the dose of sodium laurylsulfate is increased continuously.Both Brij-35 and citric acid have no suchdesorption in vivo.No significant difference of the bioavailability has been foundamong the three tetracycline suspensions.

本文应用紫外分光光度法研究了体外三硅酸镁吸附四环素的能力及其与介质 pH 的关系;并应用尿药法研究了三硅酸镁及其在表面活性剂和枸橼酸的存在下对四环素吸收的影响;测定了三种不同处方的四环素混悬剂的相对生物利用度并进行了有关参数的统计比较。实验结果表明:三硅酸镁的吸附能力随介质 pH 的高低而增减。月桂醇硫酸钠和枸橼酸在体外对三硅酸镁有明显的解吸作用,而 Brij-35的解吸作用不明显。四环素与三硅酸镁同服时,前者吸收明显减少(P<0.05)。015g月桂醇硫酸钠与0.3g 三硅酸镁同服使三硅酸镁对四环素的吸附作用有一定程度的抑制,且此抑制作用不随月桂醇硫酸钠剂量继续增大而加强。枸橼酸和 Brij-35在体内均无此作用。三种四环素混悬剂的生物利用度无显著差异(P<0.05)。

Insulin suppositories prepared with cocoa butter and 1 % surfactant NO-10 werestudied in rabbits at the dose of 3 IU/kg,and insulin enema was used as a control.The insulin level in blood at given intervals determined by radioimmunoassay.wascompared with the blood sugar level assayed by Folin-Malmoros method.In the lgC-t figure it is shown that the fatality of the drug in vivo was conform-ed with the single compartment model in which the peak time(tmax)was 0.5 hr,the peak value(Cmax)was 547 IU/ml and the eliminating...

Insulin suppositories prepared with cocoa butter and 1 % surfactant NO-10 werestudied in rabbits at the dose of 3 IU/kg,and insulin enema was used as a control.The insulin level in blood at given intervals determined by radioimmunoassay.wascompared with the blood sugar level assayed by Folin-Malmoros method.In the lgC-t figure it is shown that the fatality of the drug in vivo was conform-ed with the single compartment model in which the peak time(tmax)was 0.5 hr,the peak value(Cmax)was 547 IU/ml and the eliminating half-life(t(1/2))was 0.27hr.The relative bioavailability of insulin suppository was 83%.The time for decreasing the blood sugar level to the minimum was 1.5 hr,whilethe time for blood insulin concentration peak was 0.5 hr.

本文报导了用可可豆油做基质含有1%表面活性剂(NO-10)的胰岛素栓(剂量按家兔体重3IU/kg 计)家兔直肠吸收的研究,并用胰岛素灌肠剂作对照。用放射免疫法测定各间隔时间的胰岛素血浓度并和用 Folin Malmoros 法测得的血糖浓度进行对比。从得到的 lg C-t 图中看出,胰岛素在体内的转运过程为单隔室模型,达峰时((?)max)为0.5hr,峰值为547 IU/kg,消除半衰期(t~1/2)为0.27hr,测得胰岛素栓的相对生物利用度为83%。实验结果看出,3 IU/kg 剂量的胰岛素栓直肠给药后,家免血糖在1.5小时时降至最低,胰岛素血浓度在0.5小时时出现峰值。

 
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