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抗排卵
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  anti-ovulation
     It was observed that norgestrel and levonorgestrel could effectively inhibit the copper-induced ovulation in the rabbits, the rate of anti-ovulation was 83.3% and 66.7% separately.
     结果表明,两种18-甲基炔诺酮皆明显抑制由铜盐诱导的家兔排卵,抗排卵率分别为83.3%和66.7%。
短句来源
     It was foubd that the 3/4 dosage group maintained a very good potency, its anti-ovulation rate was 80%.
     本实验将长效复方18甲人用临床剂量折算成家兔等效剂量,分为3个不同减量组、1个全量组和1个空白对照组,其中观察到3/4剂量组获得良好抗排卵效果,抗排卵率为80%,与全量组近似.
短句来源
     It has definite anti-ovulation and anti-implantation effects.
     对家兔有显著的抗排卵与抗着床作用。
短句来源
     Accordingly, it seems that the anti-ovulation effect of norgestrel and levonorgestrel mightbe due to its inhibiting effect on hypothalamus.
     以上结果提示,消旋18-甲基炔诺酮和左旋18-甲基炔诺酮的抗排卵作用可能是通过干扰下丘脑LH-RH的释放而实现的,并非由于在垂体水平拮抗LH-RH的作用或在性腺水平上拮抗促性腺激素作用的结果。
短句来源
  “抗排卵”译为未确定词的双语例句
     ANTI-OVULATORY EFFECT OF HYPOTHALAMIC MEDROXYPROGESTERONE OR MEGESTROL IMPLANTS IN THE RABBIT
     甲孕酮和甲地孕酮植入家兔丘脑下部的抗排卵作用
短句来源
     EFFECTS OF ANTIFFRTILITY IN MICE AND ANTIOVULATION IN RABBITS BY NORETHIS-TERONE-OXIME-ENANTHATE
     庚炔诺酮肟对小鼠的抗生育作用和家兔的抗排卵作用研究
短句来源
     THE PHARMACOLOGICAL STUDY OF ANTIOVULATION EFFECT OF TAB. METHYLNORETHINORONI Ⅱ Co WITH DOSAGE DECREASED
     长效口服避孕药复方18甲减量抗排卵疗效的药理研究
短句来源
     Experimental study on antiovulatory activity of gestodene and levonorgestrel
     孕二烯酮和左旋18甲基炔诺酮抗排卵的实验研究
短句来源
     By now mainly clinical anti-pregnancy drugs are steroid-compound ones which having high position effect and always belonging to inhibiting-ovulation durgs.
     目前临床抗生育药物主要是甾体合成药,作用位点高且多系抗排卵药物,对机体内分泌有一定的干扰。 而中草药则具有特有的天然疗效,作用位点低,副作用小等特点;
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  相似匹配句对
     Intervention with anti-H.
     H.
短句来源
     Anti-H.
     H .
短句来源
     ANTI-OVULATORY EFFECT OF HYPOTHALAMIC MEDROXYPROGESTERONE OR MEGESTROL IMPLANTS IN THE RABBIT
     甲孕酮和甲地孕酮植入家兔丘脑下部的排卵作用
短句来源
     Experimental study on antiovulatory activity of gestodene and levonorgestrel
     孕二烯酮和左旋18甲基炔诺酮排卵的实验研究
短句来源
     A New Era in Ovulation Induction
     促排卵药物的新纪元
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Norgestrienone (Ⅰ_a) was prepared by partial synthesis either from Ⅹ through the following sequence of reactions: Ⅺ→Ⅸ_a→Ⅶ_a→Ⅳ_a→Ⅻ_a→ⅩⅢ_a→ⅩⅣ_a→Ⅰ_a,or directly from Ⅳ_a to ⅩⅣ_a by selective ethynylation.

三烯炔诺酮(17α-乙炔基-17β-羟基雌甾-4,9,11-三烯-3-酮,Ⅰ_a)具有较异炔诺酮(Ⅱ)更强的抗排卵作用,与炔雌醚(Ⅲ)合用乃是一种常用的口服避孕药。本品若在房事前后,单独服用低剂量,也具有抑制生育的作用。18-甲基三烯炔诺酮(18-甲基-17α-乙炔基-17β-羟基性甾-4,9,11-三烯-3-酮,Ⅰ_b)是一种抗着床的口服避孕药,每星期只需服用一次。此药既不抑制排卵,也不产生因每月服用22天含有炔雌醚的口服抗排卵避孕药而引起的副作用。三烯炔诺酮(Ⅰ_a)系用半合成方法合成,即以Ⅹ为原料,经Ⅺ→Ⅸ_a→Ⅶ_a→Ⅳ_a→Ⅻ_a→ⅫⅠ_a→ⅪⅤ_a而得Ⅰ_a,或不经Ⅻ_a及ⅫⅠ_a,即将Ⅳ_a经选择乙炔化而直接得ⅪⅤ_a。dl-18-甲基三烯炔诺酮(Ⅰ_b)用全合成方法合成,以Ⅷ_b为原料,采用与合成三烯炔诺酮相似的合成路线,经Ⅸ_b→Ⅶ_b→Ⅳ_b→Ⅻ_b→ⅫⅠ_b→ⅪⅤ_b而得Ⅰ_b。或不经Ⅶ_b及Ⅳ_b,即将Ⅸ_b与无水甲醇、氯化氢气体作用而直接得Ⅻ_b。

The hormonal control of the hypothalamo-pituitary-ovary(ocular graft)axis was investigated in the rabbits.Autotransplantation of the ovary to theanterior chamber of the eye was performed immediately after bilateral ovariec-tomy.The FSH,LH,cAMP and Progesterone content in the blood of the controlrabbits and the rabbits with ocular ovarian grafts were determined by RIA andcompetitive protein-binding assay method.The experiments disclosed thatafter exogenous intravenous administration of 5 μg/kg of GnRH,there was...

The hormonal control of the hypothalamo-pituitary-ovary(ocular graft)axis was investigated in the rabbits.Autotransplantation of the ovary to theanterior chamber of the eye was performed immediately after bilateral ovariec-tomy.The FSH,LH,cAMP and Progesterone content in the blood of the controlrabbits and the rabbits with ocular ovarian grafts were determined by RIA andcompetitive protein-binding assay method.The experiments disclosed thatafter exogenous intravenous administration of 5 μg/kg of GnRH,there was a gra-dual increment in both FSH and LH content at 30,60 and 240 mins intervals,with basically similar pattern.When the graft-bearing animals were mated withmales,the FSH,LH and cAMP content in the blood at 30,60,120 and 240 minsintervals also showed conspicuous increase of similar magnitude in both the con-trol and the experimental,groups of animals.The characteristic hemorrhagic spots on the surface of the graft,designatedas the ovulatory response,might be initiated by mating,copper acetateHCG orGnRH.The blood Progesterone content measured on the second,fourth andsixth day after the ovulatory response increased 5-6 times above normal.Further-more,the ovulatory response could be suppressed by the administration of theantifertility solution no.1 or 18-megestrol.Taken all these experimental datatogether,it is believed that the integrity of the hypothalamo-pituitary-ovary(ocular)axis is essentially normal as compared with that of the normal.The transparent cornea(‘window’)furnishes a very convenient means of carry-ing out direct and long-term observations,particularly useful for screening an-tifertility drugs and in the delineation of the relations of the different componentsof the axis.

本文研究了家兔下丘脑—垂体—(眼前房)卵巢轴的激素调节特点。实验用成年雌兔,在摘除两侧卵巢后立即将一片卵巢组织移植于眼前房。分别用放射免疫法及竞争性蛋白结合法测定正常对照组兔与移植组兔静脉血中FSH、LH、cAMP 及孕酮含量。结果表明,移植兔与正常兔一样,静脉注射GnRH(5微克/公斤)后30、60及240分钟,血中FSH 与LH 含量有逐渐增加趋势并显著高于基础水平。与雄兔交配后30、60、120及240分钟内,血中FSH、LH 及cAMP 的含量也明显上升,两组动物三项指标变化的幅度相似。交配,静脉注射醋酸铜、HCG 或GnRH,均可使移植卵巢发生典型点状出血,称为排卵反应。在出现排卵反应后的第二、第四与第六天,血中孕酮含量较给药前增加5—6倍。上述排卵反应,在不同程度上可被避孕一号与复方18甲基炔诺酮所抑制。证明了移植动物的下丘脑—垂体—(眼前房)卵巢轴的激素调节与正常物动相比,是基本一致的。通过透明的角膜(橱窗)可长期直接观察排卵进程的变化,为研究下丘脑—垂体—卵巢轴活动规律与筛选抗排卵药物,提供简便的慢性动物模型。

This paper reports the pharmacological study on a new synthetic progestogen 3-cyclo-pentyl propionate of megestrol acetate(Progestin No.1),which has been synthesized in Chinaas a new antifertility agent for women.Bioassay results have indicated that the compoundhas significant progestogenic activity and some estrogenic activity.It has definite anti-ovulation and anti-implantation effects.A certain relationship exsists between anti-implan-tation effectiveness and time of administration.Progestin No.1 had 100%...

This paper reports the pharmacological study on a new synthetic progestogen 3-cyclo-pentyl propionate of megestrol acetate(Progestin No.1),which has been synthesized in Chinaas a new antifertility agent for women.Bioassay results have indicated that the compoundhas significant progestogenic activity and some estrogenic activity.It has definite anti-ovulation and anti-implantation effects.A certain relationship exsists between anti-implan-tation effectiveness and time of administration.Progestin No.1 had 100% anti-implanta-tion effect when a single dose(1.5mg/kg)of it was given to rabbits on day-3 of coition(day 0 being the mating day).However,it did not show any efficacy when administeredpostcoitally.The experiments has also shown that as the compound was given in smalldoses(0.2mg/kg) on 3 consecutive days(day-2,-1,0),a total dosage of 0.6 mg,whichwas only 40% of the single dose,was sufficient for anti-implantation.The subacute toxicity test on the dog demonstrated that a very high dose of ProgestinNo.1(totally eight doses were given,each equivalent to 250 times the clinical dose)did notcause significant pathological changes in sex and other organs.Besides,few gastro-intes-tinal side-effects occurred in the treated animals.The clinical relevance of the results of the present study was also discussed.

本文报道了我国合成的一种长效孕激素化合物、甲地孕醇-3-环戊烷丙酸酯(简称甲孕环酯,曾称孕素1号)的药理学研究。生物检定表明该化合物具有一定的孕激素活性与雌激素活性。对家兔有显著的抗排卵与抗着床作用。实验表明药物的抗着床效果与投药时间有一定关系:交配前3天给家兔灌服单次剂量(1.5毫克/公斤)时显示100%抗着床效果;而交配当天(配前1小时)或交配后次日投药均无抗着床作用。此外,交配前连续3天(-2,-1,0天)投药、达100%抗着床效果的总剂量为0.6毫克/公斤,较单次剂量)1.5毫克/公斤)低2.5倍。狗的毒性实验表明,每次剂量相当于临床剂量250倍的甲孕环酯,在投药8次后(每二周一次),未引起性器官或其他脏器的明显病理变化,对胃肠道也无明显的副反应。本文还结合复方甲孕环酯片的临床应用,以及如何发展以孕激素为主要成分的长效避孕药进行了讨论。

 
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