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   利培酮 在 精神病学 分类中 的翻译结果: 查询用时:0.017秒
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利培酮
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  risperidone
In the abnormal HbA1c group, 2HPG after the study was higher in the clozapine treatment group [(9.5 ± 1.8) mmol/L] than in the risperidone treatment group [(7.4 ± 1.7) mmol/L] and the chlorpromazine treatment group [(7.3 ± 1.6) mmol/L].
      
Determination of risperidone at picogram level in human urine by luminol-H2O2 chemiluminescence
      
A simple flow-injection chemiluminescence method with synergistic enhancement has been investigated for the rapid and sensitive determination of antipsychotic risperidone.
      
The synergistic action was significant in the chemiluminescence system of luminol-hydrogen peroxide with risperidone as an enhancer.
      
The increased chemiluminescence intensity was correlated with risperidone concentration within the range from 10 pg mL-1 to 1.0 ng mL-1 with relative standard deviations lower than 5.0 % and the detection limit of 4 pg mL-1.
      
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Objective:To study the efficacy and toxicity of risperidone in the treatment schizophrenia. Method:Twenty inpatients meeting the criteria of schizophrenia according to the 4th edition of the Diagnostic and Statistical Manual of Mental Discorder (DSM-Ⅳ) were treated with risperidone, dosage 2-6mg/d over eight weeks. The Positive and Negative Symptom Scale (PANSS) and Extrapyramidal Symptom Rating Scale (ESRS) were used for assessment of treatment response and extrapyramidal side effects. Results:90% of subjects...

Objective:To study the efficacy and toxicity of risperidone in the treatment schizophrenia. Method:Twenty inpatients meeting the criteria of schizophrenia according to the 4th edition of the Diagnostic and Statistical Manual of Mental Discorder (DSM-Ⅳ) were treated with risperidone, dosage 2-6mg/d over eight weeks. The Positive and Negative Symptom Scale (PANSS) and Extrapyramidal Symptom Rating Scale (ESRS) were used for assessment of treatment response and extrapyramidal side effects. Results:90% of subjects showed significant and 70% marked improvement at the end of study. Improvement was first evident at the end of the first week. 45% of subjects demonstrated extrapyramidal side effect while insomnia was common. Discussion:Risperidone is effective for both positive and negative symptoms of schizophrenia.

为验证利培酮治疗精神分裂症的有效性和安全性,对20例按DSM—Ⅳ诊断的精神分裂症住院患者进行治疗,剂量2~6mg/d,疗程8周。以阳性症状和阴性症状量表(PANSS)评定疗效,以锥体外系症状评定量表(ESRS)评定锥体外系反应(EPS)。治疗结束时,显效率(痊愈+显著进步)为70%,有效率90%,利培酮治疗起效时间为1周。提示利培酮是一种对精神分裂症阳性症状和阴性症状均有一定疗效的抗精神病药物。

AIM: To observe the therapeutic effects and adverse reactions of risperidone in schizophrenia. METHODS:Risperidone was given orally 2_8 mg/d to 73 schizophrenic inpatients(M 49,F 24, age 32 a±s 12 a) for 6 wk. Therapeutic effects and adverse reactions were evaluated with the Brief Psychiatric Rating Scale and the Treatment Emergent Symptom Scale. RESULTS: The excellent response rate against schizophrenia was 47% and the effective rate was 81%. Risperidone showed better response to paranoid type, and catatonic...

AIM: To observe the therapeutic effects and adverse reactions of risperidone in schizophrenia. METHODS:Risperidone was given orally 2_8 mg/d to 73 schizophrenic inpatients(M 49,F 24, age 32 a±s 12 a) for 6 wk. Therapeutic effects and adverse reactions were evaluated with the Brief Psychiatric Rating Scale and the Treatment Emergent Symptom Scale. RESULTS: The excellent response rate against schizophrenia was 47% and the effective rate was 81%. Risperidone showed better response to paranoid type, and catatonic type than to hebephrenia,simple type and other types.The common adverse reactions were extrapyramidal symptoms and insomnia.CONCLUSION:Risperidone is an effective and safe antipsychotic agent.

目的:观察利培酮治疗精神分裂症的疗效及不良反应。方法:对73例住院的精神分裂症病人(男性49例,女性24例;年龄32a±s12a),给予利培酮1~4mg,po,bid,疗程6wk,以简明精神病量表评定疗效,以副反应量表评定药物不良反应。结果:利培酮治疗精神分裂症显效率为47%,有效率为81%。对偏执型及紧张型组的疗效明显优于青春型、单纯型、未定型及其他型组。较多见的不良反应为锥体外系症状和失眠。结论:利培酮是一种安全、有效的治疗精神分裂症药物。

Objective:To compare the efficacy and side effects between risperidone and clozapine in the treatment of schizophrenia. Method:60 inpatients with diagnosis of schizophrenia according to DSM-IV and PANSS score≥60 were treated with either risperidone or clozapine in a double blind trial.PANSS,CGI,ESRS and TESS were used to monitor the therapeutic response and side effects. Results:967% of patients showed definite response to risperidone which is comparable to clozapine.The onset of action was about one week...

Objective:To compare the efficacy and side effects between risperidone and clozapine in the treatment of schizophrenia. Method:60 inpatients with diagnosis of schizophrenia according to DSM-IV and PANSS score≥60 were treated with either risperidone or clozapine in a double blind trial.PANSS,CGI,ESRS and TESS were used to monitor the therapeutic response and side effects. Results:967% of patients showed definite response to risperidone which is comparable to clozapine.The onset of action was about one week and slightly earlier for negative symptoms.There were less extra-pyramidal side effects especially with low dose.As compared to clozapine,there were fewer side effects in general.There was also better drug compliance with superior quality of life. Discussion:Risperidone was a safe and effective treatment for schizophrenia.

60例PANSS总分≥60,符合DSM—Ⅳ精神分裂症诊断标准的患者,分别给予利培酮或氯氮平治疗。经8周随机对照研究发现,PANSS、CGI、ESRS、TESS量表评定显示,利培酮治疗精神分裂症疗效肯定,有效率96.7%,与氯氮平相仿。利培酮在治疗1周后起效,阴性症状见效尤早,剂量较小者锥体外系副反应轻,其他不良反应发生率和严重程度较氯氮平明显少而轻,治疗的依从性与生活质量较高。本研究证实,利培酮是治疗精神分裂症安全有效的药物

 
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