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子宫内免疫
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     Immunization Update
     当代免疫
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     Chain of Immunology
     免疫
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     Comparative of diagnosing value on three immunologic methods in patients with endometriosis
     三种免疫方法在子宫内异症诊断中的价值
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     Influence of Immunization with SA-30 on Mast Cells in Mouse Uterus
     精子膜抗原SA-30免疫对小鼠子宫内肥大细胞的影响
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Objective To detect the changes of immune cells in mouse uterus induced by SA 30(a Con A binding glycoprotein isolated from bovine sperms), and then reveal the influence of SA 30 immunization on the development of early mouse embryos. Methods The CD4 +、CD8 + and CD57 + cells in uterus of SA 30 immunized or control female Kunming mice were detected by immunohistochemical method(LSAB). Results On 3 day of pregnancy, much more CD4 +、CD8 + and CD57 + cells occurred in the uterus of SA 30 immunized...

Objective To detect the changes of immune cells in mouse uterus induced by SA 30(a Con A binding glycoprotein isolated from bovine sperms), and then reveal the influence of SA 30 immunization on the development of early mouse embryos. Methods The CD4 +、CD8 + and CD57 + cells in uterus of SA 30 immunized or control female Kunming mice were detected by immunohistochemical method(LSAB). Results On 3 day of pregnancy, much more CD4 +、CD8 + and CD57 + cells occurred in the uterus of SA 30 immunized mice than those of the control mice. On the other hand, the positive cells were found both in the endometrium and myometrium of immunized mice, but only in myometrium of control mice. Conclusion SA 30 can induce the cell mediated immune responses in mouse uterus, which may be toxical to the early embryos.

目的 检测SA 30抗原免疫后妊娠小鼠子宫内免疫细胞的变化 ,以了解SA 30免疫对早期胚胎发育的影响。 方法 利用免疫组织化学LSAB法 ,对SA 30免疫后的小鼠子宫内CD4+ 、CD8+ 及CD5 7+ 阳性细胞进行了检测。 结果 妊娠第 3d时 ,和对照组小鼠相比 ,SA 30免疫后的小鼠子宫内CD4+ 、CD8+ 及CD5 7+ 细胞均明显增多 ,阳性细胞在子宫肌层和内膜都有分布 ,而对照组小鼠子宫内的阳性细胞只局限于肌层 ,内膜中没有。 结论 SA 30免疫可以诱导妊娠第 3d小鼠子宫内的细胞免疫反应 ,从而可能对早期胚胎产生细胞毒性作用

 
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