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清醒大鼠     
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  conscious rats
     Results:During 30 min of myocardial ischemia, 16(16/25) conscious rats and 9(9/10) anesthetized and open-chest rats survived.
     结果:心肌缺血30min内,清醒大鼠16(16/25)只存活,而麻醉开胸大鼠9(9/10)只存活。
短句来源
     Intrathecal administration(ith)of 5-hydroxytryptamine(5-HT,1.56,3.125,6.25 and 12.5 μg/10μl)to conscious rats produced a marked dose-dependent hy-pertensive effect without significant change in heart rate(HK).
     给清醒大鼠脊髓蛛网膜下腔注射(ith)5-羟色胺(5-HT)1.56、3.125、6.25和12.5μg/1Oμl后引起明显血压升高,并呈量效关系,但心率(HR)无明显改变。
短句来源
     SA 10.6, 13.3 and 15mg/kg iv decreased markedly the early ischemic arrhythmia in conscious rats.
     SA13.3和15mg/kg显著缩小心肌梗塞范围,降低血清LDH含量,减轻清醒大鼠缺血早期心律失常。
短句来源
     When an extract of the leaves of Ligustrum robustum was given to anesthetized rats intravenously at doses of 0.098, 0.140, 0.200 g/kg the BP of the animals decreased rapidly by 37.7,38.6 and 50.2% respectively. But without any effect when given intragastrically to conscious rats at 1.36g/kg (qid × 3d ).
     粗壮女贞叶提取物静脉注射0.098、0.140和0.200g/kg可使麻醉大鼠的血压显著下降,峰值下降37.7%、38.6%和50.2%:灌胃给药(ig)1.36g/kgqd×3d,不影响清醒大鼠的血压。
短句来源
     To determine if amino acids neurotransmitters such as aspartic acid(Asp) Glu glutamine(Gln) glycine(Gly), Tau and alanine(Ala) are involved in the effect of acute hypotension on the excitation of vestibular nuclei, we measured the levels of amino acids in medial vestibular nucleus(MVN) following acute hypotension induced by sodium nitroprusside in conscious rats by the use of the methods of brain microdialysis and high liquid chromatogram analysis.
     本实验在清醒大鼠,利用脑部微量透析法和高效液相色谱分析法,静脉注射硝普钠诱发急性低血压时,观察MVN区氨基酸天冬氨酸(Aspartic acid,Asp)、Glu、谷氨酰胺(Glutamine,Gln)、甘氨酸(Glycine,Gly)、Tau和丙氨酸(Alanine,Ala)含量的变化,以了解MVN区这些物质是否参与急性低血压兴奋前庭神经核的过程。
短句来源
更多       
  conscious rat
     CHANGES OF PLASMA CGRP AND VASCULAR RESPONSE TO CGRP IN CONSCIOUS RAT DURING ENDOTOXIN SHOCK
     清醒大鼠内毒素休克时血浆CGRP浓度及血管对CGRP反应性的改变
短句来源
     AIM: To study the mechanism of antidiuretic effect of suberogorgin (Sub). METHODS: Conscious rat was given ig Sub 3.16 mg·kg-1 20 min after water-loaded treatment and then urine was collected in metabolic cage. Ion excretion was determined in atomic emission spectrometry.
     了解柳珊瑚酸(suberogorgin,Sub)抗利尿作用的机制.方法:清醒大鼠给予水负荷后ig Sub3.16 mg·kg-1,收集尿液,用原子发射光谱仪测定尿离子的总排出量;
短句来源
     Ligustrazini preconditioning protection on myocardial ischemia and reperfussion injury in the conscious rat
     川芎嗪预处理对清醒大鼠心肌缺血再灌注损伤的保护作用
短句来源
     Effect of microinjection of atrial natriuretic peptide into the paraventricular nucleus on cardiovascular in conscious rat
     室旁核微量注射心房钠尿肽对清醒大鼠心血管活动的影响
短句来源
     The expression of the immediate early gene c-fos in met-enkephalin-containing neurons of the periaqueductal gray(PAG)in conscious rat after hind paw formalin in jection or electroacupuncture(EA)of"Tsu San Li" were determined by immunocytochemical method.
     用免疫组织化学方法观察福尔马林脚掌皮下注射和足三里穴电针后清醒大鼠中脑导水管周围灰质(PAG)中快速反应基因c-fos在含甲啡肽神经元中的表达。
短句来源
  awake rats
     EEG was recorded in awake rats.
     记录清醒大鼠的EEG。
短句来源
     Method: 28 awake rats were invided into 6,6,8,8 four groups, the first two of which were peritoinjectecd saline vehicle and lappaconitine 4mg/kg respectively, the third of which received incision in the plantar of the right hindpaw and the fouth of which was peritoinjected saline vehicle 16 min prior to the same incision.
     方法:28只清醒大鼠分成6,6,8,8 四组,单纯腹腔注射(ip)生理盐水,高乌甲素4mg/kg,右后爪做外科手术和生理盐水腹腔注射16分钟后右后爪做外科手术。
短句来源
     Establishment of the model for brain injury in unanaesthetized and awake rats
     非麻醉型清醒大鼠颅脑外伤模型的建立
短句来源
     The influence of Baichuan capsule to awake rats
     白川胶囊对清醒大鼠血压的影响
短句来源
     Establishment of the model for brain injury in awake rats and studies on the DM of cerebral cells after brain injury
     清醒大鼠颅脑创伤模型的建立及创伤性脑细胞变化的数字形态学研究
短句来源
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  free moving rats
     VASOACTIVE INTESTINAL POLYPEPTIDE INDUCED PROLACTIN RELEASE IS MODEL DEPENDENT IN FREE MOVING RATS *
     血管活性肠肽对清醒大鼠催乳素分泌的影响
短句来源

 

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      conscious rats
    cava of conscious rats during continuous registration of arterial blood pressure and conductivity (reciprocal hematocrit) in blood from different circulatory areas.
          
    Acute hemodynamic effects of coronary artery ligation in conscious rats
          
    Because of the growing interest in the use of coronary artery ligation (CAL) in rats as a model for studies on heart failure, we have investigated the acute hemodynamic changes following CAL in conscious rats.
          
    Echocardiography was also performed in an additional group of unanesthetized conscious rats (group IV, n = 5).
          
    Subsequently, the monoepoxides were infused into conscious rats (35 mg/kg/h) while blood pressure, heart rate, and EKG were monitored for 24 h using biotelemetry techniques.
          
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      conscious rat
    The effects of two unrelated diuretics, furosemide and amiloride on blood glucose, plasma insulin and glucose tolerance in the conscious rat are reported.
          
    Alteration of the counterregulatory hormones in the conscious rat after protein-energy restriction
          
    Decerebration just inferior to the inferior colliculus abolished the cardiovascular, excitatory effects of morphine in the conscious rat, but left the circulatory, depressant actions of the drug unchanged.
          
    The effect of isoprenaline on plasma concentrations of immunoreactive β-endorphin and β-lipotropin in the conscious rat
          
    Differential effects of methylxanthines on local cerebral blood flow and glucose utilization in the conscious rat
          
    更多          
      awake rats
    Local glucose utilization and local blood flow in hearts of awake rats
          
    These methods could not demonstrate transmural gradients for glucose utilization and blood flow between epi- and endocardium in awake rats.
          
    The effects of inhaled 1,1,1-trichloroethane (3500, 6000, and 7800 ppm) on behavior, local cerebral blood flow, and local cerebral glucose consumption were studied in awake rats.
          
    In awake rats, recycling of fatty acids within brain phospholipids, due to deesterification and reesterification, is very rapid, with half-lives in some cases of minutes to hours.
          
    Recently we demonstrated for the first time the release of neurotrophic bioactivity in the brains of awake rats.
          
    更多          


    The lateral habenular nucleus is an efferent relay station in the pathways fromthe forebrain limbc system to the brainstem.Our previous work showed that someneurons in this nucleus were responsive to noxious stimulus(LHPE).In the pre-sent work we foundthat stimulating the septal region of conscious immobilizedrat could strongly inhibit spontaneous as well as pain-evoked discharges ofLHPE.The mean duration of inhibition to single shocks was 2.91 s;when repeti-tive shocks were given the duration was much prolonged.On...

    The lateral habenular nucleus is an efferent relay station in the pathways fromthe forebrain limbc system to the brainstem.Our previous work showed that someneurons in this nucleus were responsive to noxious stimulus(LHPE).In the pre-sent work we foundthat stimulating the septal region of conscious immobilizedrat could strongly inhibit spontaneous as well as pain-evoked discharges ofLHPE.The mean duration of inhibition to single shocks was 2.91 s;when repeti-tive shocks were given the duration was much prolonged.On the other hand elec-trolytic lesion in septal region resulted in a transient increase of the spontaneousdischarges of LHPE.In addition to LHPE,another kind of neurons(LHPI)which showed inhibitory response to pain stimulation could also be identified inthe lateral habenular nucleus.The spontaneous discharges of LHPI increasedwhen the septal region was stimulated.Still a third group of neurons inthis nucleus which was indifferent to noxious stimulation were not affected by sep,tal region stimulation.On the basis of these results a hypothetical efferent path-way for the modulation of pain sensation was suggested.

    外侧缰核是前脑边缘系统与脑干结构联系的驿站,在这个核内存在对痛刺激呈兴奋反应的神经元(LHPE)。本实验观察了边缘系统中与针刺镇痛有关的隔区与外侧缰核在疼痛方面的机能联系。在清醒的大鼠,刺激隔区明显地抑制 LHPE 的自发放电。单脉冲刺激隔区对LHPE 自发放电的平均抑制时程为2.91 s,重复刺激时则作用更强。刺激隔区还可抑制痛诱发的 LHPE 放电。损毁隔区后,LHPE 自发放电频率可暂时升高,提示隔区对 LHPE 的抑制具有张力性。在外侧缰核内还可记录到一种对伤害性刺激呈抑制反应的神经元(LHPI),刺激隔区对 LHPI 主要呈以兴奋作用,而对这个核内与痛无关神经元的影响较小。本文就以上结果在镇痛中的意义进行了讨论。

    The experiments were carried out on conscious albino rats immobilized by tubocur-arine.The spontaneous firings of nucleus locus coeruleus(LC),which is the majornucleus of noradrenergic perikarya in the brain,were recorded with glass microelec-trode autofilled.Spontaneous firings of LC with a frequency mostly at 4 spikes/swere observed.The firing rate LC was significantly decreased by intraventricular in-jection of scopolamine(250μg,3μl).Cells in the LC gave an excitatory response to noxious stimulus.This responsewas...

    The experiments were carried out on conscious albino rats immobilized by tubocur-arine.The spontaneous firings of nucleus locus coeruleus(LC),which is the majornucleus of noradrenergic perikarya in the brain,were recorded with glass microelec-trode autofilled.Spontaneous firings of LC with a frequency mostly at 4 spikes/swere observed.The firing rate LC was significantly decreased by intraventricular in-jection of scopolamine(250μg,3μl).Cells in the LC gave an excitatory response to noxious stimulus.This responsewas not depressed by scopolamine.The results obtained may demonstrate that the anesthetic action induced by scopo-lamine injected intraventricularly seems to be related to noradrenergic systemin the brain.

    实验在用箭毒制动的清醒大鼠上进行。用自动充灌型玻璃微电极引导蓝斑核单位自发放电。蓝斑自发活动多数为4次/秒的低频放电。脑室注射东莨菪碱(250μg,3μl)可使蓝斑单位放电明显抑制。痛刺激增加蓝斑单位放电,这种效应不能为东莨菪碱所拮抗。提示脑室注射东莨著碱所引起的麻醉作用对中枢去甲肾上腺素能系统有一定影响。

    228 neurons with spontaneous discharges in the periaqueductal gray(PAG)were recorded and their responses following stimulation of parafascicular nucleus(Pf)and of peripheral noxious or touch receptors were tested.76 neurons were af-fected by Pf stimulation and could be categorized into three types according to thenature of responses.8 neurons were antidromically invaded by Pf stimulation.The antidromic spike had a constant latency at a fixed stimulus intensity,with a mean3.18±0.57(SD)ms suggesting of a fine...

    228 neurons with spontaneous discharges in the periaqueductal gray(PAG)were recorded and their responses following stimulation of parafascicular nucleus(Pf)and of peripheral noxious or touch receptors were tested.76 neurons were af-fected by Pf stimulation and could be categorized into three types according to thenature of responses.8 neurons were antidromically invaded by Pf stimulation.The antidromic spike had a constant latency at a fixed stimulus intensity,with a mean3.18±0.57(SD)ms suggesting of a fine myelinated projection.All these 8 neuronshad a low frequency of spontaneous discharges(mean 1.1±0.45 Hz)and were notresponsive either to pain or touch.44 neurons were orthodromically inhibited byPf stimulation.They had a high frequency of spontaneous discharges(mean 12.1±3.7 Hz)and most of them(61.3%)could be activated markedly by peripheralpain stimulation.Pain activated discharges of these neurons could also be inhibitedby Pf stimulation.24 neurons were orthodromically activated by Pf stimulation.These neurons had a moderate frequency of spontaneous discharges(mean 5.8±1.4 Hz)and were about equally pain-sensitive and pain-inhibitive.The plausiblerole of these neurons was discussed.

    在48只清醒大鼠的中脑导水管周围灰质(PAG)记录到228个有自发放电的单位,检查了它们对束旁核(Pf)刺激和外周伤害性刺激和触刺激的反应,其中有76个单位对 pf 刺激有反应,反应型式有如下三类。8个单位在 Pf 刺激时出现逆行反应,潜伏期为3.18±0.57(SD)ms,传导速度相当于1.41m/s;这些单位的自发放电频率为1.1±0.45Hz,且不受夹尾或触尾刺激的影响。44个单位在 pf 刺激时出现顺行抑制;它们的自发放电频率为12.1±3.7(SD)Hz,且大多数单位(61.3%)在夹尾刺激时出现明显的增频反应,此反应亦可被 pf 刺激所抑制。24个单位在 pf 刺激时出现顺行兴奋;它们的自发放电频率为5.8±14(SD)Hz,对夹尾刺激表现增频或减频反应的单位数大致相等。对这些不同性质的 PAG 单位在中枢痛传递和痛感受的调制中所起的作用进行了讨论。

     
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