and reduction in the number of all cells (246±42)×108/L vs (225±33) ×108/L, P <0.01), neutrophil propo tion (75.6±6.7)% vs (71.4±6.5)%, P <0.01) in induced sputum.
The level of IL-5 in induced sputum in asthmatics(53.3±24.2)ng/L was higher than those in healthy volunteers(20.2±4.1)ng/L and in COPD(29.8±4.7)ng/L(P <0.05).
ResultsConcentrations of LTB4 in induced sputum[(794±305)pg/mg·pro] and plasma[(5 219±1 185)ng/L] in group C were significantly higher than those in group H[(347±169)pg/mg·pro,(2 283±489)ng/L,all P<0.05].
The pre- and post-therapy concentrations of LTB4 in induced sputum and plasma in group CA were (812±592),(657±459) pg/mg·pro and (5 422±935),(4 589±1 057)ng/L,respectively;
Results In patients with severe asthma,the percent predicted of FEV_1(FEV_1%pred) were(60.8±15.8)% and(53.6±15.9)% before and after sputum induction,respectively,which were different significantly(P<0.01).
The difference of LTC_4 level was also significant when CVA group (0.65±0.62)μg/L was compared with EB group (0.39±0.61)μg/L ( P< 0.05) and healthy group(0.15±0.11)μg/L(P<0.01).
The concentration of sputum ECP was (0.62±0.66) mg/L in EB group, (1.27±1.74)mg/L in CVA group, (0.07±0.10)mg/L in healthy group, the difference among the three groups being significant (P<0.01).
Results:The positive rate in the induced and spontaneous sputum from lung cancer patients and spontaneous sputum from benign lung disease patients were 80%,56.7%,and 13.3%,respectively,while the OD value of telomerase activity was 0.523±0.267,0.349±0.247,and 0.091±0.110,respectively.
After four weeks' administration, there were great decreases in percentage of total eosinophils (40 % ± 17 % vs 29 % ±11 %, P<0.01), activated (EG2+) eosinophils (28 % ±9 % vs 10 % ± 8 %, P < 0.01) and in the concentration of sputum ECP [ (373 ± 206) vs (220 ± 132) μg/L, P < 0.01].
用茶碱治疗4周后,哮喘患者诱导痰中Eos百分数下降(40％±17％ vs 29％±11％,P<0.01),EG~(2+)Eos百分数显著下降(28％±9％ vs 10 ％±8％,P<0.01),痰ECP明显下降[(373±206)vs(220±132)μg/L,P<0.01];
To develop a new method of sputum induction, asthmatics were instructed to inhale 4% sterile nebulised saline. The success rate, safety and validity of sputum induction were determined. The results indicated that sputum induction is safe, valid, and it may be useful in studying asthma or other pulmonary diseases.
Objective To explore the role of sensory neuropeptide calcitonin gene related peptide (CGRP) in the pathogenesis of chronic airway inflammatory diseases COPD and bronchial asthma Methods Patients with COPD ( n =19), bronchial asthma ( n =14), all were in stable stage and 10 normal volunteers were examined After hypertonic saline inhalation challenge in all subjects, CGRP LI concentration in the induced sputum was measured by radioimmunoassay Cellular content was assayed by microscopic analysis,...
Objective To explore the role of sensory neuropeptide calcitonin gene related peptide (CGRP) in the pathogenesis of chronic airway inflammatory diseases COPD and bronchial asthma Methods Patients with COPD ( n =19), bronchial asthma ( n =14), all were in stable stage and 10 normal volunteers were examined After hypertonic saline inhalation challenge in all subjects, CGRP LI concentration in the induced sputum was measured by radioimmunoassay Cellular content was assayed by microscopic analysis, the relation between CGRP LI level and FEV 1 value was calculated by liner regression Results The sputum CGRP concentrations in patients with COPD and patients with asthma were (15 97±2 15)ng/L, (18 79±3 91)ng/L, respectively, both were significantly higher than those in normal volunteers (2 36±0 35)ng/L Moreover, CGRP concentrations in induced sputum in each disease group were correlated with the degree of airflow obstruction, r = -0 50 and -0 61, respectively ( P <0 05) The percentage of neutrophil cell count (64 9±2 9)% was significantly higher in patients with COPD ( P <0 01), while the percentage of eosinophil cell count (5 8±0 5)% was increased in patients with asthma ( P <0 01) Conclusions The data suggested that CGRP release may participate in the chronic inflammation of patients with COPD and bronchial asthma
Objective To explore a simple and effective method of induced sputum and cellular analysis,and to investigate airway inflammation features in children with acute asthma.Methods A method to induce sputum with inhaled hypertonic saline was used in 37 acute asthmatic childhood patients and 48 normal subjects(control group) for collecting the sputum.A portion of the sputum treated with dithiothreitol(DTT) was performed to count the total cell in the hemocytomer and the other did differential cell counts in the...
Objective To explore a simple and effective method of induced sputum and cellular analysis,and to investigate airway inflammation features in children with acute asthma.Methods A method to induce sputum with inhaled hypertonic saline was used in 37 acute asthmatic childhood patients and 48 normal subjects(control group) for collecting the sputum.A portion of the sputum treated with dithiothreitol(DTT) was performed to count the total cell in the hemocytomer and the other did differential cell counts in the smear with Wright's stain and toluidine blue stain.Results In the asthmatic group,84% were successful in collecting the sputum and PEF value did not go down( P >0 05).The total cell counts were(11 2±8 9)×10 9/L in sputum from asthmatic subjects and (7 1±6 2)×10 9/L from the control subjects( P <0 05).The eosinophils and the mast cells of the asthmatic group were significantly higher than that of the control group( P <0 01) in the differential cell counts.Conclusion The analysis of the induced sputum and investigation of the airway inflammation was a safe and reliable method;eosinophils and mast cells were mainly effective cells in inflammatory response in asthma.
诱导痰
induced sputum
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