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磷酸化位点
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  phosphorylation sites
     AIM:To optimize the IκBα mutant(IκBαM)gene derived from human placenta tissue by deleting N-terminal phosphorylation sites of serine 32/36,and to construct and identify its replication-deficient recombinant adenovirus(AdIκBαM).
     目的:通过去除N端丝氨酸32/36磷酸化位点,获得人胎盘组织IκBα突变体(IκBαM)基因,构建其复制缺陷型重组腺病毒(AdIκBαM),并进行体外表达和活性检测。
短句来源
     Protein kinase C phosphorylation sites and casein kinase II phosphorylation sites are found in all the amino acid sequences of UL31, UL32, UL33 and UL34 genes, which suggests that all the four genes are possibly phosphoproteins.
     UL31、UL32、UL33与UL34基因产物均有酪蛋白激酶2磷酸化位点和蛋白激酶C磷酸化位点,表明UL31、UL32、UL33、UL34蛋白质可能都是磷酸化蛋白质。
短句来源
     Among the abovementioned phosphorylation sites, Ser198, Ser199,Ser202,Thr205,Thr231,Ser235, Ser262, Ser400 and Ser404 were seen in Alzheimer τ.
     其中 Ser- 198,Ser- 199,Ser- 2 0 2 ,Thr- 2 0 5 ,Thr- 2 31,Ser- 2 35 ,Ser- 2 6 2 ,Ser- 40 0和 Ser- 40 4为 AD患者τ蛋白异常磷酸化位点
短句来源
     Weighted SVM for Predicting Phosphorylation Sites
     Weighted SVM在蛋白质磷酸化位点预测中的应用
短句来源
     It contains one putative conservative phosphorylation site(S(51)R(52)R(52)R(54)R(56)K(60)R(63)),three phosphorylation sites of Protein kinase C,five phosphorylation sites of Tyrosinase,nine phosphorylation sites of Tyrosinase Ⅱ,three phosphorylation sites of protein kinase depended on cAMP or cGMP,two tyrosine sulphation sites and one glycosylation site.
     具有保守的磷酸化位点S(51)R(52)R(52)R(54)R(56)K(60)R(63)。 BmeIF2α有推定的3个蛋白激酶C磷酸化、5个酪氨酸激酶磷酸化、9个酪蛋白激酶Ⅱ磷酸化、3个依赖cAMP与cGMP蛋白激酶磷酸化位点,2个酪氨酸硫酸盐化位点,1个糖基化位点。
短句来源
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  phosphorylation site
     It contains one putative conservative phosphorylation site(S(51)R(52)R(52)R(54)R(56)K(60)R(63)),three phosphorylation sites of Protein kinase C,five phosphorylation sites of Tyrosinase,nine phosphorylation sites of Tyrosinase Ⅱ,three phosphorylation sites of protein kinase depended on cAMP or cGMP,two tyrosine sulphation sites and one glycosylation site.
     具有保守的磷酸化位点S(51)R(52)R(52)R(54)R(56)K(60)R(63)。 BmeIF2α有推定的3个蛋白激酶C磷酸化、5个酪氨酸激酶磷酸化、9个酪蛋白激酶Ⅱ磷酸化、3个依赖cAMP与cGMP蛋白激酶磷酸化位点,2个酪氨酸硫酸盐化位点,1个糖基化位点。
短句来源
     The bioinformatics analysis indicated that the protein encoded by cab-BO1 has a chlorophyll a/b binding domain(64 th ~232 th position),a protein kinase C phosphorylation site (9 th ~11 th position), a ubiquitin domain signature (27 th ~52 th position),and a casein kinase II phosphorylation site(55 th ~58 th position).
     cab-BO1编码的氨基酸中第64~232位包括典型的捕光叶绿素a/b结合蛋白功能域,第9~11位为蛋白激酶C的磷酸化位点,第27~52位为泛素结构功能域信号,第55~58位为酪氨酸激酶(CK2)磷酸化位点
短句来源
     Identification of the Phosphorylation Site of the V-ATPase Subunit A in Maize Roots
     玉米根V-ATPase的A亚基磷酸化位点的鉴定(英文)
短句来源
     Prosite motif research showes that there may be 2 N-glycosylation site, 6 protein kinase C phosphorylation site, 5 Casein kinase II phosphorylation site, 9 N-myristoylation site, 1 Amidation site.
     通过蛋白质结构分析表明可能含有2个N-糖基化位点,6个蛋白激酶C磷酸化位点,5个酪蛋白激酶Ⅱ磷酸化位点,9个N-豆蔻酰化位点,1个酰胺化作用位点。
短句来源
     The OsMPK4 protein contains all 11 conserved domains that are characteristics of MAPKs and phosphorylation site of TEY motif.
     预测的OsMPK4蛋白具有MAPK蛋白典型的11个保守结构域,及磷酸化位点“TEY”模体。
短句来源
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  “磷酸化位点”译为未确定词的双语例句
     METHODS: Ser 32-and Ser 36-deleted IκBα gene (ΔN IκBα) was cloned into adenovirus vector, and a replication-defective recombinant ΔN IκBα adenovirus(Ad-ΔN IκBα) was generated.
     方法: 构建去除Ser32和Ser36磷酸化位点的IκBα重组腺病毒Ad- ΔNIκBα。
短句来源
     The SS1 CagA showed more than 85% homologous to Western H. pylori strains while less than 80% to Chinese H. pylori strains, and four tyrosine phosphorylation motifs (pY117/118/122, EPIYA-A, B, and C) present in it.
     SS1株cagA与西方菌株同源性大于 85 % ,而与中国菌株的同源性小于 80 % ,具有pY117/118/12 2和EPIYA A、B、C 4个酪氨酸磷酸化位点
短句来源
     The residues of Thr and Ser at the position 435 and 473 in the NS1 gene of SD-68 strain are phosphorylated sites because they are also found at the same position in the NS1 gene of MVM(i) strain.
     在Thr435和Ser473位点猪细小病毒SD-68株与MVM(i)完全一致,表明Thr435和Ser473是猪细小病毒SD-68株NS1潜在的磷酸化位点
短句来源
     Activity of NMDA receptor after ischemic injury will mediate Ca2+ inward influx and Ca2+ overload, which leads to neuronal injury and apoptosis and induce pathological changes.
     NMDA受体上有磷酸化位点和通道阻断剂等结合位点,缺血损伤后NMDA受体激活可介导Ca2+内流和胞内Ca2+超载,引发一系列病理变化过程,导致细胞损伤和凋亡。
短句来源
     The residues of Thr and Ser at the position 435 and 473 in the NS1 gene of SD-68 strain are phosphorylated sites because they are also found at the same position in the NS1 gene of MVM(i) strain.
     在Thr435和Ser473位点PPVSD-68株与MVM(i)完全一致,表明Thr435和Ser473是PPVSD-68株NS1潜在的磷酸化位点
短句来源
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  phosphorylation sites
The predicted CbICE53 protein contained a potential basic helix-loop-helix domain, a nuclear localization signal (NLS), an RNA-binding region (RGG box), and N-glycosylation and kinase phosphorylation sites.
      
Among them, 17 phosphorylation sites in seven subunits proved to be conserved in H.
      
The tyrosine phosphorylation sites were identified in silico for the fragments of polypeptides examined.
      
Two protein kinase C phosphorylation sites and two casein kinase II phosphorylation sites are found in ASYIP amino acid sequence.
      
Identification of phosphorylation sites of proteins by high performance liquid chromatography-electrospray ionization-quadrupole
      
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  phosphorylation site
Prominin-1 mutated at its phosphorylation site inflicted a global change in the expression of several genes associated with glucose metabolism in L6 myotube cells.
      
We revealed that the N-terminal half of hhLIM mediated this activation, in which the LIM domain 1 and protein kinase C phosphorylation site are important, especially the LIM domain 1.
      
Then the phosphorylation site was identified through manual interpretation of the MS/MS spectrum of the phosphorylated peptide or automatic SEQUEST data base-searching.
      
Prediction of PK-specific phosphorylation site based on information entropy
      
However, the useful information may be lost if only the conservative residues that are not close to the phosphorylation site are considered in prediction, which would hamper the prediction results.
      
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  autophosphorylation site
The putative autophosphorylation site at His378 and the phosphate receiver site at Asp689 were also identified.
      
Furthermore, the Ct-PKAR protein is classified as a type II regulatory subunit based on the presence of the hallmark autophosphorylation site.
      
The heptapeptide EDNEYTA, which reproduces the main autophosphorylation site of Src, has been previously shown to be a good substrate for both Src and Syk tyrosine kinases [Ruzza, P., et al., J.
      
The heptapeptide EDNEYTA, which reproduces the main autophosphorylation site of Src, has been previously shown to be a good substrate for both Scc and Syk tyrosine kinases [Ruzza, P., et al., J.
      
Solid-phase synthesis of an Htc-containing dimer analog of the autophosphorylation site of pp60src PTK: Effective acylation cond
      
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Corpus luteum cells from immature female rats pretreated by PMSG-hCGwere digested with DNAase-collegnase. After centrifugation corpus luteum cells.were suspended in EDTA solution. The effect of 21 amino acids on the hCG-induced progesterone production was compared. Three dose levels (0.02 mol/L,0.2 mol/L and 2 mol/L) of each amino acids were tested and the dose of hCGwas 100 mIU/ml. Each tube containing 60 million cells/0.5 ml, hCG, anddifferent amounts of the amino acids as desired was incubated at 37℃ for1.5...

Corpus luteum cells from immature female rats pretreated by PMSG-hCGwere digested with DNAase-collegnase. After centrifugation corpus luteum cells.were suspended in EDTA solution. The effect of 21 amino acids on the hCG-induced progesterone production was compared. Three dose levels (0.02 mol/L,0.2 mol/L and 2 mol/L) of each amino acids were tested and the dose of hCGwas 100 mIU/ml. Each tube containing 60 million cells/0.5 ml, hCG, anddifferent amounts of the amino acids as desired was incubated at 37℃ for1.5 h. The change of progesterone in the tube was measured by RIA. Of the twenty-one kinds of amino acids, only tyrosine, threonine and serineinhibit the progesterone production induced by hCG. Since these three aminoacids all have hydroxyl group for phosphorylation, it is suggested that the inhibi-tory effect of the three amino acids on progesterone production induced by hCGmay be due to the interference of protein kinase phosphorylation.

本文选用PMSG-hCG预处理的未成年雌性大鼠卵巢黄体经DNA酶-胶原酶消化后,制成黄体细胞悬浮液。在黄体细胞悬浮液的培养管内,加入hCG100mIU/ml 100μl,同时加入三种浓度(0.02,0.2,2mmol/L)的二十一种氨基酸,充入95%O_2+5%CO_2,37℃孵育1.5h,用放射免疫分析方法测孕酮含量。结果表明:二十一种氨基酸中,只有酪氨酸、苏氨酸、丝氨酸可对抗hCG致孕酮生成作用。这三种氨基酸在结构上均具有羟基,都是蛋白质磷酸化的位点,据此推测:这三种氨基酸抗hCG致孕酮生成作用可能与干扰蛋白激酶的磷酸化有关。

The effects of substance D1,an extract from burn eschars,on hepatic mitochondrial respiratory function and the damages to the respiratory chain were studied in the rat.The rate of state 3 and state 4 respiration,the FCCP-stimulated respiratory rate,the respiratory control ratio,and the ratio between FCCP rate and state 4 rate were determined and the activities of NADH:cytochrome c reductase,succinate: cytochrome c reductase,NADH dehydrogenase and succinate dehydrogenase were measured.It was found that D1...

The effects of substance D1,an extract from burn eschars,on hepatic mitochondrial respiratory function and the damages to the respiratory chain were studied in the rat.The rate of state 3 and state 4 respiration,the FCCP-stimulated respiratory rate,the respiratory control ratio,and the ratio between FCCP rate and state 4 rate were determined and the activities of NADH:cytochrome c reductase,succinate: cytochrome c reductase,NADH dehydrogenase and succinate dehydrogenase were measured.It was found that D1 inhibited state 3 respiratory but stimulated state 4 respiration. There was a dosage effect relationship between the dosage of D1 and the changes of the rate of Oxygen consumption. The turning point was at the D1 concentration of 1mg/ml.The ratio of FCCP-stimulated rate with state 4 rate was decreased when the dosage of D1 increased.The experimental results were similar if glutamate,malate or succinate was used.The turning point of the ratio decreasing gradient was at the D1 concentration of 1 mg/ml.The decrease of FCCP-stimulated rate and state 4 rate indicates that there are damages to the respiratory chain. Cytochrome oxidase,the terminal segment of the chain,was intact.Therefore,the damage might occur somewhere in complexes Ⅰ~Ⅲ and Ⅱ~Ⅲ.The activities of NADH:cytochrome c reductase and succinate:cytochrome c reductase were both markedly inhibited while those of NADH dehydrogenase and succinate dehydrogenase remained intact. These findings suggest further that the damage might occur in complex Ⅲ,the bc1 complex.

本文报告烧伤焦痂提取物中可溶于有机溶剂组分D1对大鼠肝线粒体功能及呼吸链的损害作用。结果表明第3态呼吸受D1抑制,第4态受D1刺激而增高,耗氧率变化与D1用量之间存在着显著的量效关系。低剂量时耗氧率的改变缓慢,高剂量时耗氧率的变化急剧,这个转折点在D1浓度为1mg/ml处。氰化羰酰-3-氟苯腙(FCCP)/第4态耗氧率比值随D1浓度增加而下降,磷酸化位点1底物与位点2底物的实验结果相似,在D1浓度为1mg/ml处也存在一个比值下降坡度变化的转折点。FCCP/第4态耗氧率比值下降表示复合物Ⅰ~Ⅲ及Ⅱ~Ⅲ节段有损伤。与此相反,位点3底物实验中未见FCCP/第4态耗氧率比值变化,说明复合物Ⅳ无损伤。有关酶活力测定进一步证实上述呼吸链损伤的定位结果。受D1作用后,还原型辅酶Ⅰ(NADH):细胞色素c还原酶与琥珀酸:细胞色素。还原酶活力均明显下降,但复合物Ⅰ中的NADH脱氢酶与复合物Ⅱ中的琥珀酸脱氢酶活力却无改变,说明损伤的部位很可能在复合物Ⅲ即bc1complex处,有关的功能实验正在进行中。

The inhitory sites of D_1,a toxic extract from burn eschar with ethyl acetate,on the respiratory chain of liver mitochondria was determined in rats.The effect of D_1 on the electron transpot through phosphorylation site 1 was studied with the changes of NADPH redox state in various respiratory phases.It was found that D_1 did not interfere with the electron transport through site 1 or inhibit the activity of NADPH:duroquinone reductase. The phosphorylation site 2 was directly tested with duroquinol as an artificial...

The inhitory sites of D_1,a toxic extract from burn eschar with ethyl acetate,on the respiratory chain of liver mitochondria was determined in rats.The effect of D_1 on the electron transpot through phosphorylation site 1 was studied with the changes of NADPH redox state in various respiratory phases.It was found that D_1 did not interfere with the electron transport through site 1 or inhibit the activity of NADPH:duroquinone reductase. The phosphorylation site 2 was directly tested with duroquinol as an artificial electron donor and cytochrome c as electron receptor. It was found that D_1 inhibited the activity of this enzyme dosedependently.The redox state of the electron carrier cytochrome b was not influenced by D_1. However,a transient oxidation of cytochrome c_1 was demonstrated suggesting a brief inhibtion on its reducing side.Two inhibitory sites in site 2 were found after studying the TMPD and DCIP by-passes.One was at the reducing side of cytochrome c_1 and the other at the reducing side of cytochrome b.Further investigation is imperative to find out the exact position and the nature of these inhibitory sites.

本文报告焦痂提取物中可溶于乙酸乙酯的毒性组含D_1对大鼠肝线粒体呼吸链的抑制位点;用还原型辅酶Ⅱ(NADPH)在各呼吸态氧化还原变化观察D_1对线粒体体磷酸化位点1通过电子流的影响。D_1不阻滞电子流通过位点1,D_1亦不影响辅酶Ⅱ(NADP):四甲基对苯醌还原酶(Duroquinonereductase)活力。用四甲基氢醌(duroquinol)作为电子供体,细胞色素c为电子受体可直接测试位点2的功能状态,D_1能抑制duroquinol:细胞色素C还原酶(cytochromecreductase)活力,其抑制程度与D_1浓度有关,位点2中的电子载体细胞色素b的氧化还原状态不被D_1所抑制,D_1可造成细胞色素c_1移过性氧化过程,说明其还原侧有短暂的抑制,四甲基对苯胺(TMPD)及2,6-二氯靛酚(DCIP)旁路试验表明D_1在位点2内有两处抑制点;一处在细胞色素c_1的还原侧,一处在细胞色素b的还原侧;其性质及确切部位尚待进一步研究。

 
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