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异常表达
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  abnormal expression
    The abnormal expression of c-erbB-2 and protein P 53 in transitional cell bladder carcinoma
    癌基因c-erbB-2和抑癌基因P~(53)在膀胱移行细胞癌中的异常表达
短句来源
    Study on the abnormal expression of carbohydrate antigen 19-9 in the urine samples of the patients with bladder cancer
    糖类抗原19-9在膀胱癌患者尿液中异常表达
短句来源
    The Abnormal Expression of PTEN Protein in Bladder Transitional Cell Carcinoma
    膀胱移行细胞癌PTEN蛋白异常表达研究
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    ResultsThe abnormal expression rate of E - cad and β - cat were 69.1% and 77.9% respectively, In 58 cases (85.3% ) , the expressions of E - cad and β - cat were abnormal or normal simultaneously, and significant correlation between them were suggested by the Spearman correlation analysis ( r = 0. 642, P < 0.05 ) .
    68例肿瘤组织中 E,cad及 p-cat的异常表达率分别为 69.1%和77.9%,其中58例u5.3%)二者同时正常或异常表达,二者表达之间显著相关(r=0.642,P<0.05)。
短句来源
    The abnormal expression rate of E - cad andp - cat in G1, G2 and G3 were 35. 3% ,63. 6% ,93. 1% and 47.1% ,77. 3% ,96. 6% respectively;
    E-CCd及 p-CCt在I、11、见级肿瘤中的异常表达率分别为35.3%,63.6%,93.1%和47.1%,77.3%,96.6%;
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  abnormal expressions
    Comparative study of abnormal expressions of WT1、P57kip2、H19 and IGF2 genes in Wilm's tumors
    肾母细胞瘤中WT1、P57kip2、H19及IFG2基因异常表达的比较研究
短句来源
    Conclusion Abnormal expressions of cdk2 and cdk4 that result in aberrations of cell cycle and cell proliferation are involved in the pathogenesis of BPH and PC.
    结论:cdk2和cdk4异常表达参与BPH和PC的发生发展过程,其可能是通过改变细胞周期及促进细胞异常增殖而起作用的。
短句来源
    Conclusion The abnormal expressions of p 16 and cyclin D 1 proteins play an important role in the occurrence and progress of transitional cell of urinary bladder.
    结论 p16和cyclinD1异常表达在膀胱TCC发生发展中起重要作用
短句来源
    Multivariate analysis indicated that only the combined abnormal expressions of p53, p21/WAF1 and pRb provided prognostic information in T 1G 3 TCC of the bladder.
    多因素分析显示 ,p5 3、pRb同时异常表达 (P <0 .0 5 )和p5 3、p2 1/WAF1、pRb三者同时异常表达(P <0 .0 1)与肿瘤进展显著相关。
短句来源
    Conclusion The abnormal expressions of MMP-9 and TIMP-1 may contribute to the progression of IgA nephropathy.
    结论 MMP 9和TIMP 1的异常表达可能是影响IgA肾病进展的因素之一
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  “异常表达”译为未确定词的双语例句
    Abnormalities of anti-oncogene p53 in renal cell carci-noma
    抗癌基因p53在肾癌组织的异常表达及其意义
短句来源
    RELATION OF OVEREXPRESSION OF c-myc AND Ha-ras mRNA TO MALIGNANCY AND CLINICAL CHARACTERISTICS
    人膀胱移行细胞癌c-myc、Ha-ras mRNA异常表达与临床肿瘤生物学行为的对照研究
短句来源
    Overexpression of P53 in transitional cell bladder cancer detected by microwave immunohistochemical technique
    膀肤癌P53基因异常表达产物的微波免疫组化研究
短句来源
    Conclusions The high expressions of Survivin and Bcl-2 could be regarded as indications of poor prognosis in BTCC. There are closely relation between Survivin,Bcl-2 and p53 in BTCC.
    结论Survivin和Bcl-2的高表达提示膀胱癌预后不良,Survivin在BTCC组织中的表达与Bcl-2、p53的异常表达密切相关。
短句来源
    [Conclusion] Abnormality of E2F-1expression is involved in development and progression of COK, especially plays an important role in renal fibrosis.
    结论E2F-1异常表达参与梗阻性肾病的发病过程,尤其在肾纤维化过程中发挥重要作用。
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  abnormal expression
In our present study we tested the hypothesis that the decreased FHIT expression resulted in apoptosis inhibition associated with abnormal expression of apoptosis related proteins.
      
Modern data are reviewed that concern hereditary disorders caused by abnormal expression of imprinted genes rather than mutations and structural aberrations.
      
Regulatory mechanisms for abnormal expression of the human breast cancer specific gene 1 in breast cancer cells
      
Thus, our results suggest that the abnormal expression of BCSG1 in breast cancer cells is likely regulated by multiple mechanisms.
      
A critical promoter element involved in abnormal expression of BCSG1 presents in the first exon.
      
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  abnormal expressions
Abnormal expressions of the subunits of the UDP-N-acetylglucosamine: lysosomal enzyme, N-acetylglucosamine-1-phosphotransferase,
      
A lower ratio of +KTS/-KTS and an abnormal distribution of WT1, as well as abnormal expressions of other podocyte molecules, were also revealed.
      
The equine protease inhibitory system (Pi): Abnormal expressions of PiF, PiL, and PiS
      
Recent studies have shown that the abnormal expressions of GAS and SS are closely related to cell apoptosis of large intestine cancer.
      


In order to study the relationships of bladder carcinoma with epidermal growth factor receptor(EGFR)and p53,the author used the repeated PAP immunocytochemical method in which the bridge anti-body and PAP reagent were repeated several times.By using the above method,EGFR and p53 protein ex-pression products were detected in paraffin-embedded sections of 58 clinical bladder cancer samples.The re-sults showed that EGFR was distributed in cytoplasm and cellular membrane with a positive rate of 34.5%while p53 protein...

In order to study the relationships of bladder carcinoma with epidermal growth factor receptor(EGFR)and p53,the author used the repeated PAP immunocytochemical method in which the bridge anti-body and PAP reagent were repeated several times.By using the above method,EGFR and p53 protein ex-pression products were detected in paraffin-embedded sections of 58 clinical bladder cancer samples.The re-sults showed that EGFR was distributed in cytoplasm and cellular membrane with a positive rate of 34.5%while p53 protein was localized mainly in nucleus with a small amount in cytoplasm and its positive rate was27.6%. Their positive rates were significantly different in pathological classifications and clinical stages ofcarcinoma (P<0.05).It is suggested that abnormal expression of EGFR and p53 protein was positively corre-lated with the degree of differentiation and invasiveness of bladder carcinoma.

为了研究表皮生长因子受体(epidermalgrowthfactorreceptor,EGFR)和P53蛋白与膀胱肿瘤之间的关系,作者应用多重PAP免疫细胞化学方法,通过增加PAP的次数,提高了方法的敏感性,克服了抗体效价低和不适合在石蜡切片上染色的不足,对58例石蜡包埋的膀胱肿瘤组织切片进行了检测.结果发现:EGFR的阳性率为34.5%.它定位在细胞膜和胞浆内,而P53蛋白的阳性率为27.6%,主要定位在胞核内,少部分在胞浆内.它们的阳性率在肿瘤的病理分级和临床分期中差异显著(P<0.05),提示EGFR和P53蛋白的异常表达与膀胱肿瘤的分化和浸润程度呈正相关.

We have studied the expression of multidrug resistance,(MDR1) gene in 28 specimens from patients with bladder cancer with no prior exposure to chemotheraputic drugs and in 12 normal bladder mucosa specimens by reverse transcription-polymerase chain reaction(RTPCR). MDR1 gene specific 167bp amplified fragments were found in 23 tumor and 5 normal tissues, and β-microglobilin gene specific 120bp amplified fragments were found in all specimens. These results suggested that intrinsic MDR1 gene expression is present...

We have studied the expression of multidrug resistance,(MDR1) gene in 28 specimens from patients with bladder cancer with no prior exposure to chemotheraputic drugs and in 12 normal bladder mucosa specimens by reverse transcription-polymerase chain reaction(RTPCR). MDR1 gene specific 167bp amplified fragments were found in 23 tumor and 5 normal tissues, and β-microglobilin gene specific 120bp amplified fragments were found in all specimens. These results suggested that intrinsic MDR1 gene expression is present in both the bladder tumor and normal bladder tissues, and implied that to a variety of chemotheraputic drugs in bladder tumors might be related to the expression of MDR1 gene. In addition, our data showed that RT-PCR is both sensitive and reliable for detecting MDR 1 gene expression.

应用逆转录酶链式反应(RT-PCR)技术,以β-微球蛋白基因为内对照,对28例术前未接受化疗的膀胱癌标本及12例正常膀胱粘膜MD1基因的表达进行了分析,82.1%(23/28)膀胱癌和41.7%(5/12)正常膀胱粘膜在167bp处显示MDR1基因特异的扩增片段,全部标本在120bp处显示β-微球蛋白基因特异的扩增片段。结果表明,膀胱癌及正常膀胱粘膜存在内源性MDR1基因的表达,从而提示膀胱癌患者对化疗药物敏感性的差异可能与其MDR1基因的异常表达有关。同时证实RT-PCR技术是一种灵敏的,可靠的MDR1基因表达的检测方法。

Expression of P53, c-erb B-2, and PCNA proteins was studied in prostate tissues from 88 patients with primary advanced prostate carcinomas, 12 with BPH, and 10 normal prostate for comparison by means of immunohistochemistry and image analysis. Strong nucleus statining was found in 28% (25/88) of tumors for P53 protein, 68%(60/88) of tumors for membrane bound c-erb B-2 oncoprotein, and 74% (65/88) of tumors for high (>50%) PCNA proliferating cell index. The c-erb B-2 overexpression is more frequent than abnormal...

Expression of P53, c-erb B-2, and PCNA proteins was studied in prostate tissues from 88 patients with primary advanced prostate carcinomas, 12 with BPH, and 10 normal prostate for comparison by means of immunohistochemistry and image analysis. Strong nucleus statining was found in 28% (25/88) of tumors for P53 protein, 68%(60/88) of tumors for membrane bound c-erb B-2 oncoprotein, and 74% (65/88) of tumors for high (>50%) PCNA proliferating cell index. The c-erb B-2 overexpression is more frequent than abnormal P53 expression. More prostate carcinomas were stained compared with benign lesions or normal prostate control (P<0.05).No statistical association was found between P53 and/or c-erb B-2 expression and histologic grade, clinical stages, or the age of patients, as no statistically significant differences were found between P53 and/or c-erb B-2 and DNA ploidy, PCNA index ,and S-phase fraction measured by FCM. The atypical basal cell or transitional cell hyperplasia adjacent to tumor showed P53 protein immunoreactivity in 12%(9177), as well as with c-erb B-2 expression, and high PCNA index. The result provides evidence that the atypical basal cell or transitional cell hyperplasia might accompany the premalignant phenotype, and correlate with basal cell prostate carcinoma. The application of P53, c-erb B-2 and PCNA protein co-expression seems to be a superior methods for investigating the pathogenesis of prostate carcinoma and distinguishing a typical hyperplasia and early prostate carcinoma.

88例前列腺癌组织应用免疫组化、图像分析及流式细胞仪(FCM)方法,检测癌基因P~(53),c-erbB-2及增殖细胞核抗原PCNA的表达及DNA含量。P~(53)异常表达率为28%(25/88),c-erbB-2过度表达率为68%(60/88).PCNA(>50%)增殖指数值为74%(65/88).与对照组前列腺良性增生及正常前列腺组织中呈阴性反应对比有明显差异(P<0.05),与癌组织分化程度、临床分期及DNA含量无明显相关(P>0.05)。77例癌旁前列腺基底细胞异型增生上皮中有9例(12%)亦显示P~(53),c-erbB-2及PCNA的异常表达,提示该异型增生的基底细胞具有恶性表型。表明前列腺癌中P~(53),c-erbB-2及PCNA的异常表达与癌发生有一定关系,以c-erbB-2过度表达尤为重要,3种抗体的联合应用可作为前列腺癌的肿瘤标志物,对前列腺癌发病机理研究及预测早癌发生有一定价值,但作为患者预后判断的指标尚显不足。

 
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