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原发性iga肾病
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  primary iga nephropathy
     Primary IgA Nephropathy in Children: Association of Clinical and Pathological Findings with Prognosis
     儿童原发性IgA肾病临床病理及预后的研究
短句来源
     Clinicopathologic characteristics and prognosis of primary IgA nephropathy in children
     儿童原发性IgA肾病临床病理特征及预后分析
短句来源
     Imaging Analysis Research on IgA Deposits of Primary IgA Nephropathy
     原发性IgA肾病IgA沉积物的图像分析研究
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     The prognosis of primary IgA nephropathy with DR4 antigen is not benign and the patients with DR4 antigen is apt to cause renal function deterioration.
     具有DR4抗原的原发性IgA肾病预后不良,该类病人容易出现肾功能减退。
短句来源
     Objectives To explore the clinical manifestations,pathological features,and prognosis of primary IgA nephropathy(IgAN)in children.
     目的探讨儿童原发性IgA肾病(IgAN)的临床、病理特征及预后。
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  idiopathic iga nephropathy
     Patients with idiopathic IgA nephropathy were found to have higher percentage of glomerular sclerosis (64.86% vs 40.00%) and ratio of sclerostic glomeruli to total glomeruli [ (26.98 ±24.68)% vs (16.10 ±18.80)% ]as compared to LN group, which further predicated the progressing characteristics of IgA nephropathy.
     原发性IgA肾病患者的球性硬化发生率(135例/ 222例,64.86%)、球性硬化数与肾小球总数的比率[(26.98±24.68)%]均显著高于LN组[30例/73 例,40.00%,(16.18±18.80)%]。
短句来源
     Results Vasculitic/crescentic lesion was found in 39.19% (87/222) patients with idiopathic IgA nephropathy.
     结果原发性IgA肾病中较常发生V/C损害,发生率为39.19%;
短句来源
     Objective To analyze the pathological and clinical characteristics of patients with idiopathic IgA nephropathy accompanied by vasculitic/crescentic lesion (IgA-V/C).
     目的了解原发性IgA肾病中微血管损害及新月体形成(V/C)的临床、病理特点。
短句来源
     Methods Data of 222 patients diagnosed as idiopathic IgA nephropathy by renal biopsy, among them 87 cases with vasculitic/crescenlic (V/C)lesion, from our department in 2004 were analyzed retrospectively. Clinical and pathological data from patients with IgA-V/C were compared to those of non-IgA-V/C patients and of lupus nephritis (LN) patients with V/C lesion.
     方法以2004年确诊并行肾穿刺活检证实的87例伴V/C损害的原发性IgA肾病与同期135例不伴V/C损害的原发性IgA肾病以及伴有V/C的狼疮肾炎患者的临床、病理资料进行比较。
短句来源
     The Pathologic Features and Clinical Manifestation of Idiopathic IgA Nephropathy
     原发性IgA肾病病理与临床分析
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  “原发性iga肾病”译为未确定词的双语例句
     Amount of CD_4~+,CD_8~+ and B cells in the sections of renal biopsies obtainedfrom 20 patients with IgA nephropathy,10 with heavy proteinuria(NP)and 10 withrecurr(?)
     本文应用单克隆抗体和PAP四层法观察了20例原发性IgA肾病患者肾活检组织中CD_4~+、CD_8~+和B 细胞的分布。
短句来源
     Materials and Methods: 61 patients of primary IgAN wereselected as research subjects, among which 31 are male and27 are female, with an average age of 34. 19±11.7 yearsold.
     资料与方法:本文选择了61例原发性IgA肾病患者为研究对象,其中男34例,女27例,平均年龄34.19±11.7岁。
短句来源
     Methods:507 patients with primary IgAN proved by renal biopsy and clinical-manifestations were enrolled in this study (male:271cases, famale: 236 cases, Age: 11-68years).
     方法:收集经临床及肾活检证实的507例原发性IgA肾病患者,其中男性271例,女性236例,年龄11-68岁。
短句来源
     Objective: To observe the expression of P27 and PCNA form paraffin-embedded renal tissue sections of patients with IgA nephropathy and explore the relationship among P27, PCNA, pathological classification and Zheng differentiation-classification of IgA nephropathy.
     目的:运用免疫组化方法研究原发性IgA肾病患者肾组织中P27、PCNA的表达,探讨两者与IgA肾病病理分级及其中医证型之间的关系。
短句来源
     Objective:To observe the expression of P 27 and PCNA form paraffin-embedded renal tissue sections of patients with IgA nephropathy and explore the relationship among P 27 , PCNA, pathological classification and TCM syndrome of IgA nephropathy.
     目的 :运用免疫组化方法研究原发性IgA肾病患者肾组织中细胞周期调控蛋白P2 7(P2 7)、增殖细胞核抗原PCNA(PCNA)的表达 ,探讨两者与IgA肾病病理分级及其与中医证型之间的关系。
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  primary iga nephropathy
The localization of the membrane attack complex of complement (MAC) was examined in the normal human kidneys and in biopsy specimens from patients with primary IgA nephropathy by immunofluorescent and immunoelectron microscopies.
      
C4 and factor B typing were performed in 37 pediatric patients with primary IgA nephropathy.
      
We have previously reported the presence of circulating IgA-fibronectin complexes in adult patients with primary IgA nephropathy.
      
Primary IgA nephropathy in children: Association of clinical and pathological findings with prognosis
      
Primary IgA nephropathy is a disease characterized by recurrent macroscopic or microscopic hematuria and diffuse mesangial IgA deposition.
      
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  idiopathic iga nephropathy
Course and long-term outcome of idiopathic IgA nephropathy in children
      
The long-term outcome of idiopathic IgA nephropathy (IgAN) in children was investigated with regard to clinical course and biopsy changes.
      
At this stage of development in our understanding of this common nephropathy, it is important to guard against the assumption that idiopathic IgA nephropathy is one disease and is the result of a single pathogenetic mechanism.
      
We present an evidence-based evaluation of published data on therapy for children with various presentations of the IgA nephropathies - idiopathic IgA nephropathy (IgAN) and Henoch-Sch?nlein purpura nephritis (HSPN).
      
These parameters were analysed in 50 patients with idiopathic IgA nephropathy and 32 age-matched controls.
      


Amount of CD_4~+,CD_8~+ and B cells in the sections of renal biopsies obtainedfrom 20 patients with IgA nephropathy,10 with heavy proteinuria(NP)and 10 withrecurr(?)nt gross hematuria(GH)were investigated by PAP(4 layer)method and mono-clonal antibodies.It was found that CD_4~+,CD_8~+ and B cells were distributed mainly inthe interstitium and rarely in the glomeruli.Their amount was increased in IgA nephro-pathy than that of normal controls.It was more abundant in NS than in GH;CD_(?)2.08±1.17/25mm~2;Interstitial...

Amount of CD_4~+,CD_8~+ and B cells in the sections of renal biopsies obtainedfrom 20 patients with IgA nephropathy,10 with heavy proteinuria(NP)and 10 withrecurr(?)nt gross hematuria(GH)were investigated by PAP(4 layer)method and mono-clonal antibodies.It was found that CD_4~+,CD_8~+ and B cells were distributed mainly inthe interstitium and rarely in the glomeruli.Their amount was increased in IgA nephro-pathy than that of normal controls.It was more abundant in NS than in GH;CD_(?)2.08±1.17/25mm~2;Interstitial fibrosis,tubular damage and CD_4~+ focal cluster were morecommon in NS than in GH.No association was found between interstitial immune depositsand infiltrating Cells in these two groups.It suggested that interstitial infiltrating lymphocytes may play a role in the patho-genesis of IgA nephropathy and that cellular immune mechanism may be important deter-minants for the impairment.It may also explain the fact why the prognosis of NSpatients was not so good as GH.

本文应用单克隆抗体和PAP四层法观察了20例原发性IgA肾病患者肾活检组织中CD_4~+、CD_8~+和B 细胞的分布。其中10例临床表现为大量蛋白尿(NP 组),另10例为反复发作性肉眼血尿(GH组)。结果发现IgA 肾病患者肾组织中CD_4~+、CD_8~+和B 细胞主要分布在间质中,肾小球内很少有淋巴细胞。NP 组和GH 组间质中CD_4、CD_8~+和B 细胞均明显高于正常对照组,其中NP 组增高更为明显。三组RT 值之间无显著差异。两组病人肾小球病变无明显不同,但NP 组间质小管病变明显重于GH 组。在NP 组还可见到间质中有较多的CD_4~+细胞聚集现象。本研究显示NP 组患者预后较差,可能与其间质淋巴细胞浸润程度以及小管间质损伤较重有关。

Cytokines may play an important role in the development of IgA nephropathy(IgAN). In this study,the levels of Interieukin-6(IL-6) activity in the urine and serum from 21 patients with IgAN were measured by using IL- 6 dependent cell line, 7TD_1. IL-6 activity were detectable in both urine and serum in patients with IgAN(IL-6 detectable rate 47. 6% and 25% respectively), while it was undetectable in normal volunteers. There was no correlationship between urinary and serum IL- 6 activity. Also, we found that patients...

Cytokines may play an important role in the development of IgA nephropathy(IgAN). In this study,the levels of Interieukin-6(IL-6) activity in the urine and serum from 21 patients with IgAN were measured by using IL- 6 dependent cell line, 7TD_1. IL-6 activity were detectable in both urine and serum in patients with IgAN(IL-6 detectable rate 47. 6% and 25% respectively), while it was undetectable in normal volunteers. There was no correlationship between urinary and serum IL- 6 activity. Also, we found that patients with elevated urinary IL-6 activity had heavy proteinuria and severe glomerular and tubularinterstitial histological changes. The results suggest that the measurement of EL-6 is useful in evaluating the degree of glomerular and interstitial damage in patients with IgAN.

用白介素6(IL-6)依赖细胞株7TD_1细胞,测定了21例原发性IgA肾病(IgAN)患者尿和血清IL-6活性水平,并分析了IL-6活性水平与IgAN临床及病理改变的联系.结果示IgAN尿及血清IL-6活性均增高(分别占46.7%及25%),尿IL-6活性增高与血清IL-6活性水平无平行关系.尿IL-6活性水平与IgAN严重蛋白尿的发生以及肾小球病变程度(节段肾小球硬化、新月体、系膜增生等)有关,亦与小管-间质病变的严重程度有关.因而尿IL-6测定,对IgAN的临床分析具有十分重要的意义.

Eighty patients with chronic renal failure caused by glomerulonephritis underwent tissue typing for HLA-A,B and DR antigens by the standard method using a microlymphocytotoxicity test.There was no significant correlation between HLA-A,B antigens and this disease.However,the frequency of HLA-DR4 was 48% in the patients with chronic renal failure and 19.81% in the control group.It is statistically significant in the patients with chronic renal failure produced by glomerulonephritis (corrected P<0.05).The result...

Eighty patients with chronic renal failure caused by glomerulonephritis underwent tissue typing for HLA-A,B and DR antigens by the standard method using a microlymphocytotoxicity test.There was no significant correlation between HLA-A,B antigens and this disease.However,the frequency of HLA-DR4 was 48% in the patients with chronic renal failure and 19.81% in the control group.It is statistically significant in the patients with chronic renal failure produced by glomerulonephritis (corrected P<0.05).The result of this study suggests that the high frequency of DR4 antigen in South Chinese patients with chronic renal failure is related to the increased morbility of primary IgA nephropathy in this area.The prognosis of primary IgA nephropathy with DR4 antigen is not benign and the patients with DR4 antigen is apt to cause renal function deterioration.

作者应用标准微量淋巴细胞毒试验方法,对我国南方80例肾小球肾炎所致慢性肾衰患者和580例正常人进行HLA分型。结果发现:本病与HLA-A,B抗原无显著相关,而与HLA-DR4抗原显著相关(P<0.005)。慢性肾炎肾衰患者的DR4抗原频率为48%,正常对照则为19.8%。推测我国南方慢性肾炎肾衰患者的DR4抗原高频率与该地区的原发性IgA肾病发病率有关。具有DR4抗原的原发性IgA肾病预后不良,该类病人容易出现肾功能减退。

 
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